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Accupain (Tramadol)
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Accupain

Accupain is used to relieve moderate to moderately severe pain. Accupain is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Other names for this medication:
Accupain, Admadol, Antram, Armadol, Arrestadol, Bolodol, Cemadol, Contramal, Cosdol, Damol, Dolex, Dolfre, Dolocet, Dolomed, Gemodol, Meridol, Midol, Neutram, Nobligan, Nosdol, Opiran, Orchidol, Painadol, Painex, Rimol, Simol, Tacil, Takol, Topspas, Tradol, Tramacon, Tramak, Tramakind, Tramatas, Trambax, Tramoflex, Tramol, Tramot, Tranzat, Trapain, Trazac, Tremtec, Tromar, Trugesic, Ultrazac, Urgendol, Victadol

Similar Products:
Imdur, Viramune, Minocin, Ditropan, Urispas, Requip, Gesic, Lipizem, Albentin, Lipanthyl, Vonavir, Lumbril, Askaworm,

Also known as: Tramadol

Description

Accupain (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Accupain is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Accupain ER) is for around-the-clock treatment of pain. Accupain ER is not for use on an as-needed basis for pain.

Dosage

Follow the directions on your prescription label and read all medication guides. Never use Accupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Accupain ER.

Never share Accupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Accupain ER.

Accupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Accupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Accupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Accupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Accupain ER dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Accupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Accupain ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Accupain ER should not be given to a child younger than 12 years old. Accupain ER should not be given to anyone younger than 18 years old.

Do not give Accupain ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Accupain ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Accupain ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Accupain ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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To investigate the immune effects of Lactobacillus rhamnosus GG (LGG) on immune response. There were no differences in the cytotoxic effect of other anticancer drugs, but there was similar resistance to nucleoside analogues via hENT-1 between the parental and resistant cells. A strategy to reduce older driver injuries at intersections using more accommodating roundabout design practices. Little is known about how VHL mutation leads to activation of Nur77. Therefore, some common problems affect diagnostic errors, although specific faults characterising errors in laboratory medicine should lead to preventive and corrective actions if evidence-based quality indicators are developed, implemented and monitored. By raising awareness and understanding of depression among primary healthcare and other healthcare practitioners, more depressed elderly with comorbid medical problems can be successfully identified and helped. The fast developing field of RNA interference (RNAi) requires monitoring of small interfering RNA (siRNA) delivery to targeted organs and evaluating the efficiency of target gene silencing. Nucleotide sequence of the ARG3 gene of the yeast Saccharomyces cerevisiae encoding ornithine carbamoyltransferase. Induction of stress proteins by hyperosmolarity in normal and transformed cells. The postoperative course was uneventful, and the histologic study of the resected specimen was confirmed microscopically to be a leiomyosarcoma.

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Ligands responsible for the transport of various Shc isoforms into organelles such as the nucleus have yet to be reported. Evidence suggests that allergy is a significant triggering factor in asthma in children and adults alike. A feasibility study to evaluate pelvic peritoneal anatomy with a saline intraperitoneal sonogram (SIPS). The specimens were exposed to anti-c-kit antibodies to investigate ICC differentiation. Histopathology showed that the prostatic urethra was destroyed by treatment. These quantities are parameters in a simple lumped parameter model that predicts pressure and flow in the systemic circulation. Neutrophils play a key role in the early host-defense mechanisms due to their capacity to migrate into inflamed tissues and phagocytose microorganisms. In the nucleus, the matrix protein binds to the newly assembled RNPs and NEP then binds to the matrix protein.

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Pulse-chase studies revealed ubiquitin to turn over with a half-life of 28-31 h in conditioned and freshly fed cultures. By minimizing symmetric transfer errors, we thus obtain an accurate solution for the camera parameters. A variety of placebo-controlled and open studies have demonstrated the effectiveness of hydroxychloroquine in the treatment of rheumatoid arthritis. The majority of individuals with depression experience sleep disturbances. Cross-sections revealed the microstructural arrangement of biominerals, showing the progressive mineralization of the organic protoconch prior to metamorphosis. On the other hand, when a hydroxide ion is present at the Mn2 site, a lower activation energy and a structural arrangement closer to the experimental indication are obtained. Constant shuttling of actin is an example of the versatility of this regulatory avenue, as this protein has the capability to drive the transcriptional activity of certain gene sets as well as influence transcription on a global scale. Minimal effect of ectopic gene conversion among recent duplicates in four mammalian genomes. Associated with ethynyl estradiol potentiates its action upon the cutaneous effectors, and at the same time has a potent ovulostatic action.

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To test the hypothesis that lung function and health status are associated with traffic exposures. Moreover, ASH1 may propagate a stem cell microenvironment in BOA where epithelium becomes resistant to naphthalene toxicity. Amaricoccus kaplicensis is probably not responsible for the failure of activated sludge systems removing phosphorus, and other organisms capable of anaerobic substrate assimilation should be sought. Randomly selected lower-extremity angiograms were examined according to the Bollinger system. It is a matter of serious concern for water managers and environmental researchers. The most common reason given for taking AAS and other hormones was to increase muscle mass and strength, but some participants also used insulin as a means of losing fat.

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Dysplastic features, growth retardation, malrotation of the gut, and fatal ventricular septal defect in a 4-month-old girl with ring chromosome 15. A deep biopsy or conization is necessary when punch biopsy is not sufficient for diagnosis. To assess how the arterial wall of the carotid artery changes with age in normal subjects by cardiovascular magnetic resonance (CMR). Results found that playing violent games causes significantly higher sympathetic activity and diastolic blood pressure than playing nonviolent games. After many discussions, the patient was ultimately treated with mirtazapine 15 mg at bedtime, in addition to ECT.

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Even though mtDNA repair capacity appears to be adequate the accumulation of mtDNA mutations has been shown to be at least one important molecular mechanism of human aging. In conclusion, the authors necessitate more strict control over total concentration of welding aerosol solid component (WASC) in air of workplace and determination of MAC for WASC. Asbestos-induced and smoking-related disease: apportioning pulmonary function deficit by using thin-section CT. The tLDA was performed by replating bone marrow adherent cells at lower density (1.25 x 10(4) cells/cm(2)) than usual, allowing for transient adherence of no more than 3 h, followed by trypsin digestion. The cutaneous receptive fields of the driven EPSPs overlapped, indicating an absence of convergence of mossy fibers activated from different receptive fields. If subsequent natural history studies link increased FDG-PET activity in carotid arteries with clinical events, this noninvasive measure could be used to identify a subset of patients with carotid atherosclerosis in need of intensified medical therapy or carotid artery intervention to prevent stroke. Sudden cardiac death associated with J wave elevation in the inferolateral leads: insights from a multicenter registry. RAP was sufficiently occluded in all patients by using microcoils in a supraselective approach. Recent genome-wide association studies identified an association between single-nucleotide polymorphisms (SNPs) in the C8orf13 region of BLK, the B lymphoid tyrosine kinase gene, with systemic lupus erythematosus (SLE) in Caucasians. A case of Crimean-congo hemorrhagic fever with pleural effusion.

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This DNA-tethering protocol circumvented the interferences from thiol compounds in common enzymatic systems. Legal considerations in cross-jurisdictional sharing of public health laboratory services. Pneumonectomy and resection-anastomosis in malignant tumors of the lung. Forkhead box transcription factor 1 (FOXM1) has been reported to overexpress and correlate with pathogenesis in a variety of human malignancies. This different organization could be responsible for the different sperm binding affinity observed for sperm to the outer region versus the inner region of the ZP. The aim of this study was to investigate the correlations of CMTM7 expression and survival rate in patients with non-smallcell lung cancer (NSCLC). Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. The anti-inflammatory effect of Gigukjiwhangwhangami through the inhibition of nuclear factor-kappaB activation in the peripheral blood mononuclear cells of patients with cerebral infarction. At development stages 16 up to 28 (2.5 to 6 days incubation), a reversed flow component in the dorsal aorta was demonstrated using the bidirectional spectrum analyzer.

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It was not possible to identify any major differences between subgroups of children within the LI group, identified as pragmatically impaired (PI) and non pragmatically impaired (NPI), in terms of either answers given to inferential questions or in terms of problematical justifications for these answers. Spin quantitation establishes that this new resonance does not arise from CuA and suggests that high pH breaks the magnetic coupling present at the cytochrome a3-CuB center. School administrators, health centers, and neighboring private physicians generally welcomed the program. The aim of this study was to assess outcomes of ileal pouch-anal anastomosis in obese patients compared with a matched cohort of nonobese patients. When combined with the results of standard TIE methods, a solid-phase cation extraction and elution approach identified copper as the most probable cause of toxicity. Using prokaryotic expressed GST-PrP fusion protein as antigen, rabbits were immunized subcutaneously. This study represents the largest series of patients with average-risk MB/PNETs treated with a combination of reduced-dose RT and adjuvant chemotherapy whose intellectual development has been followed prospectively. Lipopolysaccharide (LPS) from periodontal pathogens can penetrate gingival tissues and stimulate the production of interleukin-1beta (IL-1beta), which has been implicated in inflammation and bone resorption. By 24h, beneficial effects were evident in parameters particularly unstable in culture (glycogen content, P450), whereas no changes were produced in well-preserved functions (glucose, urea and albumin synthesis, glutathione, drug-conjugating enzymes). Clinico-pathologic conference: hemiplegia and coma in acute lymphatic leukemia.

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We report a case of granulomatous periorificial dermatitis (GPD). It had theoretically grounded associations with indicators of health and psychosocial work characteristics, and it discriminated between gender and age groups and industrial branches in accordance with the validated emotional exhaustion scale. A lumbosacral transitional vertebra is one such rare congenital anomaly that has clinical and medicolegal implications. The dual Tafel slope behaviour is ascribed to the potential dependence of the surface coverage of adsorbed intermediates. Family educational interventions have demonstrated encouraging results in relapse prevention, but follow-up data are limited and application to patients who have limited social networks may be problematic. In its 2002 report on Guidelines for the Prevention of Intravascular Catheter-Related Infections, the Centers for Disease Control and Prevention estimated that 250,000 cases of central vascular catheter-related infections occur annually. In this study we analyzed the occurrence of ischemic brain stroke in Northern Poland in regard to risk factors. Similar effects of these inhibitors were observed with respect to the production of PGE(2) and no major difference was observed between aortic tissues from normal and cholesterol-fed animals with regard to inhibitor sensitivity. This has led us to examine in depth how SMC3 level affects cell growth and genomic stability.

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Radiographs showed significant left glenohumeral joint space narrowing and a normal-appearing joint space on the right. Furthermore, the protocol permits the aortic stenosis proteome to be analysed, advancing our knowledge in this area. The C-terminal part of MTCBP-1 is identical to Sip-L, which is reported to be important for human hepatitis C virus replication. Comparison of ATPase activity of cardiac sarcoplasmic reticulum fraction from rat and dog. Primer extension analysis of RNA extracted from acute transfections with plasmids containing the bovine papillomavirus type 1 LCR driving the CAT gene revealed that each of the P7940 and P89 promoters is responsive to E2 trans-activation. The slope of the relationship between horizontal distance and flight initiation distance (horizontal slope) increased with increasing body mass across species, whereas the slope of the relationship between vertical distance and flight initiation distance (vertical slope) decreased with increasing body mass. Two different kinds of gelatin are mixed to prepare the dichromated gelatin. Hearing improvement seems to be negatively correlated with the length of the delay before the fistula is closed. Effects of third-order spherical aberration on the 3-D incoherent optical transfer function.

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Our data support the notion that second line responders are androgen independent but still hormonally sensitive. Congenital superior oblique palsy with superior oblique hypoplasia also can be classified as a CCDD by the MRI documentation of congenital aplasia of the trochlear nerve. The aim of this study was to pilot test a screening approach to detect potential look-alike, sound-alike (LASA) errors in pediatric outpatient prescriptions. Perceptions of a high-risk result were obtained using display rankings of percentages and ratios. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. symmetrel medication

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Analysis of clinical manifestations and pathology of lupus nephritis: a retrospective review of 82 cases. NAC can affect several signaling pathways involving in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and inflammatory response. A 50-year-old fisherman presented with numbness of the left hand and headache after a fall on the deck of a boat. Paramagnetic contrast agents also affect susceptibility and modify the prilosec dosage 40 mg twice daily magnetic field in proportion to their concentration. Eighty-four consecutive patients undergoing laparoscopic treatment of endometriosis with complete cul-de-sac obliteration with 67 replying to a postoperative questionnaire. Hot spot: epidemiology of measles and rubella in Germany and the WHO European region. These factors may be considered as risk factors for later development of ED among young adult women. Consistently, CX3CL1-induced EPSC depression is absent in slices from A(3)R(-/-) but not A(1)R(-/-) or A(2A)R(-/-) mice. Fibroblast growth factor 21 (FGF21) is a key regulator in glucose and lipid metabolism and its plasma levels have been shown to be increased not only in humans in different situations such as type 2 diabetes, obesity, and nonalcoholic fatty liver disease but also in animal models of sepsis and pancreatitis.

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