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Accupain (Tramadol)

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Accupain is used to relieve moderate to moderately severe pain. Accupain is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Other names for this medication:
Accupain, Admadol, Antram, Armadol, Arrestadol, Bolodol, Cemadol, Contramal, Cosdol, Damol, Dolex, Dolfre, Dolocet, Dolomed, Gemodol, Meridol, Midol, Neutram, Nobligan, Nosdol, Opiran, Orchidol, Painadol, Painex, Rimol, Simol, Tacil, Takol, Topspas, Tradol, Tramacon, Tramak, Tramakind, Tramatas, Trambax, Tramoflex, Tramol, Tramot, Tranzat, Trapain, Trazac, Tremtec, Tromar, Trugesic, Ultrazac, Urgendol, Victadol

Similar Products:
Imdur, Viramune, Minocin, Ditropan, Urispas, Requip, Gesic, Lipizem, Albentin, Lipanthyl, Vonavir, Lumbril, Askaworm,

Also known as: Tramadol


Accupain (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Accupain is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Accupain ER) is for around-the-clock treatment of pain. Accupain ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Accupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Accupain ER.

Never share Accupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Accupain ER.

Accupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Accupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Accupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Accupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Accupain ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Accupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Accupain ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Accupain ER should not be given to a child younger than 12 years old. Accupain ER should not be given to anyone younger than 18 years old.

Do not give Accupain ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Accupain ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Accupain ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Accupain ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Letter: Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens. The evidence supports provision of regular prompted recall and review of people with diabetes by willing general practitioners and demonstrates that this can be achieved, if suitable organisation is in place. These results demonstrate that agonist-mediated sequestration of the beta AR can occur in the absence of the C-terminus of the protein and reveal a strong correlation between effective coupling to Gs and sequestration. There is a need for trials to evaluate the efficacy of oral antibiotics against intravenous antibiotics in the community setting as there are service implications for cost and comfort. We conclude that pain induced by ALA-PDT is of such intensity in about one-fifth of the warts that pain relief is indicated. The temperament of the child, individual differences and environmental forces. Furthermore, boys carrying the 7r allele of DRD4 exhibited both greater rates of attention decrement in infancy and higher scores on NS in adolescence.

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To investigate the immune effects of Lactobacillus rhamnosus GG (LGG) on immune response. There were no differences in the cytotoxic effect of other anticancer drugs, but there was similar resistance to nucleoside analogues via hENT-1 between the parental and resistant cells. A strategy to reduce older driver injuries at intersections using more accommodating roundabout design practices. Little is known about how VHL mutation leads to activation of Nur77. Therefore, some common problems affect diagnostic errors, although specific faults characterising errors in laboratory medicine should lead to preventive and corrective actions if evidence-based quality indicators are developed, implemented and monitored. By raising awareness and understanding of depression among primary healthcare and other healthcare practitioners, more depressed elderly with comorbid medical problems can be successfully identified and helped. The fast developing field of RNA interference (RNAi) requires monitoring of small interfering RNA (siRNA) delivery to targeted organs and evaluating the efficiency of target gene silencing. Nucleotide sequence of the ARG3 gene of the yeast Saccharomyces cerevisiae encoding ornithine carbamoyltransferase. Induction of stress proteins by hyperosmolarity in normal and transformed cells. The postoperative course was uneventful, and the histologic study of the resected specimen was confirmed microscopically to be a leiomyosarcoma.

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In the quest for renewable resources, algae are increasingly receiving attention. Group field theory is an emerging field at the boundary between Quantum Gravity, Statistical Mechanics and Quantum Field Theory and provides a path integral for the gluing of n-simplices. pylori infection and correlate with histological or serological severity of chronic gastritis. Alkaline phosphodiesterase I activity was already at high levels in 15 day foetal liver and, as early as the 19th day of gestation, it reached adult levels. In most instances, chemotherapy should not be the first line of treatment. In the third case electron microscopy revealed aberrant melanosomes within the tumor cells. In case of adequate myocardial preservation of the cardiac graft, the aorta may be completely occluded and the recipient systemic circulation can be sustained by the graft. Innovative systems of funding the healthcare needs of older persons have also evolved over the past few years.

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Ligands responsible for the transport of various Shc isoforms into organelles such as the nucleus have yet to be reported. Evidence suggests that allergy is a significant triggering factor in asthma in children and adults alike. A feasibility study to evaluate pelvic peritoneal anatomy with a saline intraperitoneal sonogram (SIPS). The specimens were exposed to anti-c-kit antibodies to investigate ICC differentiation. Histopathology showed that the prostatic urethra was destroyed by treatment. These quantities are parameters in a simple lumped parameter model that predicts pressure and flow in the systemic circulation. Neutrophils play a key role in the early host-defense mechanisms due to their capacity to migrate into inflamed tissues and phagocytose microorganisms. In the nucleus, the matrix protein binds to the newly assembled RNPs and NEP then binds to the matrix protein.

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Pulse-chase studies revealed ubiquitin to turn over with a half-life of 28-31 h in conditioned and freshly fed cultures. By minimizing symmetric transfer errors, we thus obtain an accurate solution for the camera parameters. A variety of placebo-controlled and open studies have demonstrated the effectiveness of hydroxychloroquine in the treatment of rheumatoid arthritis. The majority of individuals with depression experience sleep disturbances. Cross-sections revealed the microstructural arrangement of biominerals, showing the progressive mineralization of the organic protoconch prior to metamorphosis. On the other hand, when a hydroxide ion is present at the Mn2 site, a lower activation energy and a structural arrangement closer to the experimental indication are obtained. Constant shuttling of actin is an example of the versatility of this regulatory avenue, as this protein has the capability to drive the transcriptional activity of certain gene sets as well as influence transcription on a global scale. Minimal effect of ectopic gene conversion among recent duplicates in four mammalian genomes. Associated with ethynyl estradiol potentiates its action upon the cutaneous effectors, and at the same time has a potent ovulostatic action.

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Dysplastic features, growth retardation, malrotation of the gut, and fatal ventricular septal defect in a 4-month-old girl with ring chromosome 15. A deep biopsy or conization is necessary when punch biopsy is not sufficient for diagnosis. To assess how the arterial wall of the carotid artery changes with age in normal subjects by cardiovascular magnetic resonance (CMR). Results found that playing violent games causes significantly higher sympathetic activity and diastolic blood pressure than playing nonviolent games. After many discussions, the patient was ultimately treated with mirtazapine 15 mg at bedtime, in addition to ECT.

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Even though mtDNA repair capacity appears to be adequate the accumulation of mtDNA mutations has been shown to be at least one important molecular mechanism of human aging. In conclusion, the authors necessitate more strict control over total concentration of welding aerosol solid component (WASC) in air of workplace and determination of MAC for WASC. Asbestos-induced and smoking-related disease: apportioning pulmonary function deficit by using thin-section CT. The tLDA was performed by replating bone marrow adherent cells at lower density (1.25 x 10(4) cells/cm(2)) than usual, allowing for transient adherence of no more than 3 h, followed by trypsin digestion. The cutaneous receptive fields of the driven EPSPs overlapped, indicating an absence of convergence of mossy fibers activated from different receptive fields. If subsequent natural history studies link increased FDG-PET activity in carotid arteries with clinical events, this noninvasive measure could be used to identify a subset of patients with carotid atherosclerosis in need of intensified medical therapy or carotid artery intervention to prevent stroke. Sudden cardiac death associated with J wave elevation in the inferolateral leads: insights from a multicenter registry. RAP was sufficiently occluded in all patients by using microcoils in a supraselective approach. Recent genome-wide association studies identified an association between single-nucleotide polymorphisms (SNPs) in the C8orf13 region of BLK, the B lymphoid tyrosine kinase gene, with systemic lupus erythematosus (SLE) in Caucasians. A case of Crimean-congo hemorrhagic fever with pleural effusion.

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This DNA-tethering protocol circumvented the interferences from thiol compounds in common enzymatic systems. Legal considerations in cross-jurisdictional sharing of public health laboratory services. Pneumonectomy and resection-anastomosis in malignant tumors of the lung. Forkhead box transcription factor 1 (FOXM1) has been reported to overexpress and correlate with pathogenesis in a variety of human malignancies. This different organization could be responsible for the different sperm binding affinity observed for sperm to the outer region versus the inner region of the ZP. The aim of this study was to investigate the correlations of CMTM7 expression and survival rate in patients with non-smallcell lung cancer (NSCLC). Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. The anti-inflammatory effect of Gigukjiwhangwhangami through the inhibition of nuclear factor-kappaB activation in the peripheral blood mononuclear cells of patients with cerebral infarction. At development stages 16 up to 28 (2.5 to 6 days incubation), a reversed flow component in the dorsal aorta was demonstrated using the bidirectional spectrum analyzer.

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We report a case of granulomatous periorificial dermatitis (GPD). It had theoretically grounded associations with indicators of health and psychosocial work characteristics, and it discriminated between gender and age groups and industrial branches in accordance with the validated emotional exhaustion scale. A lumbosacral transitional vertebra is one such rare congenital anomaly that has clinical and medicolegal implications. The dual Tafel slope behaviour is ascribed to the potential dependence of the surface coverage of adsorbed intermediates. Family educational interventions have demonstrated encouraging results in relapse prevention, but follow-up data are limited and application to patients who have limited social networks may be problematic. In its 2002 report on Guidelines for the Prevention of Intravascular Catheter-Related Infections, the Centers for Disease Control and Prevention estimated that 250,000 cases of central vascular catheter-related infections occur annually. In this study we analyzed the occurrence of ischemic brain stroke in Northern Poland in regard to risk factors. Similar effects of these inhibitors were observed with respect to the production of PGE(2) and no major difference was observed between aortic tissues from normal and cholesterol-fed animals with regard to inhibitor sensitivity. This has led us to examine in depth how SMC3 level affects cell growth and genomic stability.

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Radiographs showed significant left glenohumeral joint space narrowing and a normal-appearing joint space on the right. Furthermore, the protocol permits the aortic stenosis proteome to be analysed, advancing our knowledge in this area. The C-terminal part of MTCBP-1 is identical to Sip-L, which is reported to be important for human hepatitis C virus replication. Comparison of ATPase activity of cardiac sarcoplasmic reticulum fraction from rat and dog. Primer extension analysis of RNA extracted from acute transfections with plasmids containing the bovine papillomavirus type 1 LCR driving the CAT gene revealed that each of the P7940 and P89 promoters is responsive to E2 trans-activation. The slope of the relationship between horizontal distance and flight initiation distance (horizontal slope) increased with increasing body mass across species, whereas the slope of the relationship between vertical distance and flight initiation distance (vertical slope) decreased with increasing body mass. Two different kinds of gelatin are mixed to prepare the dichromated gelatin. Hearing improvement seems to be negatively correlated with the length of the delay before the fistula is closed. Effects of third-order spherical aberration on the 3-D incoherent optical transfer function.

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Left ventricular function is impaired in patients with MS regardless of the severity of the disease. We hypothesized that prostanoids modulate differentiation and apoptosis in cultured human trophoblasts. Silencing L-selectin expression by siRNA attenuated metastasis of murine lymphoid neoplasm cell P388D1 to peripheral lymph nodes. Sex and asymmetry in humans: what is the role of developmental instability?. Human subjects can report many items of a cluttered field moduretic tab a few hundred milliseconds after stimulus presentation.

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Growth hormone did not affect the apparent secretion of either BP. A pilot study to examine maturation of body temperature control in preterm infants. Whether this method can reduce the mortality of preterm neonates needs to be evaluated further. In vitro tetraploid induction and generation of tetraploids from mixoploids in Dioscorea zingiberensis. The aim of this review is to evaluate recent immunophenotype knowledge of hematopoietic stem cells and their restricted progenies committed to myeloid lineage - common myeloid progenitors, myelo-monocytic progenitors, megakaryo-erythroid progenitors and granulocyte progenitors up to mature neutrophil granulocyte. These findings provide the structural basis for improving our understanding of the early steps acticin of co-translational protein sorting. The advantage of a gastrointestinal shunt is that it can be performed under local anesthesia in patients who are often in poor condition.

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With 1 exception each for VEGF and VEGF-R1, none of the 34 tumours expressed either VEGF, TGF-beta1, VEGF-R1 or -R2. Proteomic analysis of interstitial fluid in bone marrow identified that peroxiredoxin 2 regulates H(2)O(2) level of bone marrow during aging. The equipment of OP is 16-channel maximum OMM-2000 device (Shimadzu, Tokyo, Japan). Because of the high cost for care of individuals with this syndrome, it is essential to apply appropriate interventions to prevent this problem. Only STI/HIV knowledge and gender roles were found as common factors across the five successful STI/HIV intervention programs and should be incorporated into future intervention programs that are culturally and gender specific. Anti-hepatitis C virus RdRp activity and replication of novel anilinobenzothiazole derivatives. Cutaneous appendageal carcinomas are rare tumors with IRs that vary by sex and racial/ethnic group. l-Glutamate and l-cystine, but not l-arginine, protected from the inactivation with an IC(50) similar to the K(m). The XPC protein is a component of a heterotrimeric complex that is essential for damage recognition in a nucleotide excision repair subpathway that operates throughout the genome.

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Analysis of clinical manifestations and pathology of lupus nephritis: a retrospective review of 82 cases. NAC can affect several signaling pathways involving in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and inflammatory response. A 50-year-old fisherman presented with numbness of the left hand and headache after a fall on the deck of a boat. Paramagnetic contrast agents also affect susceptibility and modify the prilosec dosage 40 mg twice daily magnetic field in proportion to their concentration. Eighty-four consecutive patients undergoing laparoscopic treatment of endometriosis with complete cul-de-sac obliteration with 67 replying to a postoperative questionnaire. Hot spot: epidemiology of measles and rubella in Germany and the WHO European region. These factors may be considered as risk factors for later development of ED among young adult women. Consistently, CX3CL1-induced EPSC depression is absent in slices from A(3)R(-/-) but not A(1)R(-/-) or A(2A)R(-/-) mice. Fibroblast growth factor 21 (FGF21) is a key regulator in glucose and lipid metabolism and its plasma levels have been shown to be increased not only in humans in different situations such as type 2 diabetes, obesity, and nonalcoholic fatty liver disease but also in animal models of sepsis and pancreatitis.

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