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Acertil (Aceclofenac)

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Acertil is an angiotensin-converting enzyme (ACE) inhibitor (ACEI). It exerts a protective effect in DR by decreasing VEGF-to-PEDF ratio (downregulating VEGF and upregulating PEDF). The lowering of VEGF-to-PEDF ratio is significantly correlated with the relief of the vascular damage and was a result of reduced mitochondrial ROS production by increasing uncoupling protein 2 (UCP-2).

Other names for this medication:
Aceclofenac, Acertil, Acerycal, Armix, Asyntilsan, Bionoliprel, Bipreterax, Cardipen, Coveram, Coverene, Coverex, Covinace, Domanion, Dorover, Indapril, Inopil, Midopril, Noliprel, Pendoril, Pendrex, Percarnil, Perindan, Perindox, Prestarium, Preterax, Prexanil, Prexum, Prindace, Procaptan, Stopress, Teraxans, Vectoryl, Vidotin

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Also known as: Aceclofenac


Acertil (perindopril) is an ACE inhibitors. ACE stands for angiotensin converting enzyme.

Acertil is used to treat high blood pressure (hypertension) and to prevent heart attack in people with coronary artery disease.


Usual Adult Dose for Coronary Artery Disease:

Initial dose: 4 mg orally once a day for 2 weeks, then increase to maintenance dose as tolerated. Maintenance dose: 8 mg orally once a day Use: Treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction.

Usual Adult Dose for Hypertension:

Initial dose: 4 mg orally once a day Maintenance dose: 4 to 8 mg orally per day in 1 or 2 divided doses Maximum dose: 16 mg/day Comments: In patients treated with a diuretic, consider reducing the diuretic dose prior to starting this drug.

Usual Geriatric Dose for Coronary Artery Disease:

Greater than 70 Years: Initial dose: -Week 1: 2 mg orally once a day -Week 2: 4 mg orally once a day, then increase to maintenance dose as tolerated. Maintenance dose: 8 mg orally once a day Use: Treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction.

Usual Geriatric Dose for Hypertension:

Initial dose: 4 mg orally per day in 1 or 2 divided doses Comments: Experience with doses above 8 mg is limited; administer with careful blood pressure monitoring and dose titration.

Detailed Acertil dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Acertil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Acertil if you are allergic to Acertil components. Be careful with Acertil if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Be very careful when you are driving machine. Acertil may lower your resistance to infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch you eyes or the inside of your nose unless you have thoroughly washed your hands first. Do not stop taking Acertil suddenly.

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