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Aclene (Adapalene)

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Aclene is a topical retinoid with FDA approval for the treatment of acne vulgaris. Clinicians use retinoids are used to treat a wide variety of skin disorders. Aclene also has multiple off-label therapeutic applications.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Motilium, Provera, Combivent, Diovan, Amaryl, Metoxiprim, Foben, Pioplus, Eurozol, Nocid, Zeric, Durabec, Loxapac, Alfix,

Also known as: Adapalene


Aclene (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Aclene is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Follow the directions for using this medicine provided by your doctor. Use Aclene exactly as directed. Aclene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Aclene. Aclene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Aclene. Continue using Aclene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Aclene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aclene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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Infants of Central Asian ethnicity and those born in rural areas were also considerably more at risk of mortality than suggested by the official sources. In later elongation stage (stage IV), the chromatin fibers organize in a helical form and fuse side by side giving lamellar systems which have a reticular structure. Forty-two AILD patients were included in the experimental group (group E), and 11 healthy subjects were recruited as the control group (group C). Cellulose synthase-like proteins in the D family share high levels of sequence identity with the cellulose synthase proteins and also contain the processive beta-glycosyltransferase motifs conserved among all members of the cellulose synthase superfamily. The vacuole of the yeast Saccharomyces cerevisiae contains a proton-translocating ATPase that acidifies the vacuolar lumen and generates an electrochemical potential across the vacuole membrane. The developmental and physiological consequences of disrupting genes encoding beta 1 and beta 2 adrenoceptors. We have tabulated the results of 68 cases found to have a neoplasm at the initial laparotomy and of 38 patients with pristine choledochal cysts treated electively who subsequently developed a neoplasm. To compare the reliability and accuracy of the coronal curvature measurements from US images on children who have adolescent idiopathic scoliosis (AIS) with and without the knowledge of previous radiographs.

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Combined transplantation of endothelial progenitor cells and mesenchymal stem cells into a rat model of isoproterenol-induced myocardial injury. In Study 2, 69 participants (37 women, 32 men) were recruited to judge the degree of romance in sentences presented on a computer screen one by one. Preparing the Small Animal Hospital for Avian and Exotic Animal Emergencies. A primary cell culture model for defective cardiac myofibrillogenesis in Mexican axolotl embryos. Use of immunologic, bacteriologic and allergologic methods to evaluate working conditions. In this article, the principles of economic assessment are introduced and two case studies of nurse-led innovation are used to illustrate how they are applied in practice. A multicenter collaborative and validation effort is encouraged to reach a consensus on this issue. It occurs under thoroughly mild conditions, and formate is the only product. The goal of this study was to design a reliable method to quantify and visualize the anatomical distribution of cerebrospinal fluid (CSF) intracranially.

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Relationship between egg size and post-hatching chick mortality in the herring gull (Larus argentatus). Assessment of exposure to chemical agents and ergonomic stressors in tanneries in Kanpur, India. Four days later, she presented with symptoms of a small bowel obstruction and was found to have evisceration through a laterally placed 8-mm robotic port site. Blood samples were also taken from the radial and pulmonary arteries to determine the epinephrine concentrations. Counting is carried out twice: a few days and a month after the sample preparation using the Quantulus, a liquid scintillation spectrometer equipped with a guard counter and pulse-shape analyser.

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The exposure of day-old chicks to infectious bronchitis and the subsequent development of the oviduct. The lack of differences in postzygotic processes coupled with direct observation of pollen performance traits indicates that nonrandom mating in Arabidopsis thaliana is prezygotic, due mostly to differential pollen germination and pollen tube growth rates. The RT-PCR product from rat retinal insulin receptor mRNA corresponded to the high affinity insulin receptor isoform. The oxoclusters, covalently anchored to the polymer network, act as metal-organic cross-linkers, thus improving the thermomechanical properties of the resulting hybrid nanoparticles. Optimal implementation necessitates strategies to surmount organizational and behavioral barriers to change. The ultrasonographic findings were generally consistent in the cows with LDA. This can be facilitated by settings aside time for communication and relationship building through structured meetings about PCMH components as well as the implementation process itself.

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Modification of sucrose dependent cell adherence by deletion and reintroduction of the gtf genes in Streptococcus mutans. Evaluation of the Bionic trap to quickly kill fisher (Martes pennanti) in simulated natural environments. Helicobacter pylori strains demonstrate substantial variability in the efficiency of transformation by plasmids from Escherichia coli, and many strains are completely resistant to transformation. The mode of inheritance is uncertain, but mild macular disease in the father may represent heterozygote manifestation of a recessive condition. Effects of tetrabromobisphenol A on the green alga Chlorella pyrenoidosa. This abnormal movement mirrors the mid-systolic onset of both outflow tract obstruction and mitral regurgitation.

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Phenoxybenzamine in neurogenic bladder dysfunction after spinal cord injury. Here we review emerging information on the role of Lin28 in cancer and immunity and the molecular mechanisms it uses. In vivo localization and characterization of functional ciliary neurotrophic factor receptors which utilize JAK-STAT signaling. Noncardia gastric cancer is associated with short stature but not with high body weight or obesity. Our patient demonstrated a rare presentation of sarcoidosis involving the genital region, with histopathologic evidence of transepithelial elimination of granulomas. Piperaceae used in folk medicine--a comparative anatomical-histochemical study. Ile178 is highly conserved among mammalian microsomal P450s with the exception of CYP4A and CYP19 enzymes which exhibit a Met at this alignment position. More appropriate health economic trials in GERD, which focus on GERD management strategies and therapeutic treatment of GERD, need to be ultram renal dosing designed and conducted. Review of the English literature using MEDLINE has been performed between 1963-2008 on small renal masses, partial nephrectomy, kidney cancer, nephron sparing surgery (NSS), radical nephrectomy, laparoscopy, and surgical management. Evaluation of mean platelet volume in unruptured ectopic pregnancy: A retrospective analysis.

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While there have been remarkable advances in hearing research over the past few decades, there is still no cure for Sensorineural Hearing Loss (SNHL), a condition that typically involves damage to or loss of the delicate mechanosensory structures of the inner ear. Probing the Role of Inflammation in Age-Related Macular Degeneration. In addition, they should be planned for long-term growth and performed in the fewest possible surgical stages. Older men with two or more prevalent vertebral fractures, different types of fractures (wedge, biconcave, and/or crush), fractures in both the thoracic and lumbar regions, and a degree of vertebral body compression in the three worst quartiles are at an especially high risk of sustaining new fractures. Improved methods and resources for paramecium genomics: transcription units, gene annotation and gene expression. Our preliminary study revealed that low preoperative AGR could serve as a valuable and easily-assessed blood-based indicator to predict the prognosis of LSCC patients. The striking differences in survival require clarification but lend weight to the evidence that stroke management may differ between northern and central Europe and influence outcome.

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The modulation transfer function of the polymer GRIN lens exceeded that of the homogeneous glass lens at all spatial frequencies and was as much as 3 times better at 5 cyc/mm. PCA suggested first-order entropy, median, GLRLM-based run length non-uniformity, and run percentage as the distinguished features. Connective tissue research traditionally has been experimental in nature, with computational tools used primarily for data analysis and statistical treatment. For the first time, CDs-605 were found to be capable of imaging biofilm-encased microorganisms, including E. We then discuss the potential of gene therapy for curing acquired or inherited deafness and the major obstacles that must be overcome before clinical application can be albenza drug class considered. It is shown that forbidden patterns can be used to detect determinism in irregularly sampled time series for low degrees of sampling irregularity (as defined in the paper). This process is resettable and reversible by heating up the chip to melt the paraffin and reconfigure the microchannel design on demand, offering the advantages of cost, adaptability, and robustness.

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