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Alfatrim (Trimethoprim)
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Alfatrim

Alfatrim is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The risk of side effects may be higher in the elderly.

Other names for this medication:
Bacterol, Bactoprim, Bactricida, Biotrim, Bismoral, Canibioprim, Dotrim, Eusaprim, Globaxol, Groseptol, Infectrin, Kaftrim, Medibiot, Methoxasol, Organosol, Politrim, Regtin, Ribatrim, Sulfamethoxazol, Sulfoprima, Sulphatrim, Suprimass, Tagremin, Trimesulf, Tripur

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Also known as: Trimethoprim

Description

This medication is used to treat a wide variety of bacterial infections. It is also used to treat a certain type of pneumonia (pneumocystis pneumonia) in patients with a weakened immune system. This medication is a combination of 2 antibiotics: sulfamethoxazole and trimethoprim. It works by stopping the growth of bacteria and the pneumocystis fungus.

Dosage

This section provides information on the proper use of a number of products that contain sulfamethoxazole and trimethoprim. It may not be specific to Alfatrim DS. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets): For treatment of bacterial infections: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Weighing 40 kilograms (kg)—4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Weighing 30 kg—3 teaspoonfuls (15 mL) of oral liquid or 1 ½ tablet 2 times a day for 10 days. Weighing 20 kg—2 teaspoonfuls (10 mL) of oral liquid or 1 tablet 2 times a day for 10 days. Weighing 10 kg—1 teaspoonful (5 mL) of oral liquid 2 times a day for 10 days. Children younger than 2 months of age—Use is not recommended. For treatment of bronchitis: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended. For treatment of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. Weighing 80 kilograms (kg)—10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 64 kg—8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls (30 mL) or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls (25 mL) or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls (15 mL) or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 16 kg—2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Weighing 8 kg—1 teaspoonful (5 mL) 4 times a day for 14 to 21 days. Children younger than 2 months of age—Use is not recommended. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor. The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (eg, Monday, Tuesday, Wednesday). However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. Children younger than 2 months of age—Use is not recommended. For treatment of traveler's diarrhea: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.

Storage

Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfatrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in children 2 months of age and older. Because of the toxicity of the combination of sulfamethoxazole and trimethoprim, use in infants younger than 2 months of age is not recommended.

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The use of proteomic strategies supported by transcriptomic data allows a more comprehensive assessment of venom proteomes uncovering components that are gender-specific. We sought to present a series of 13 pregnancy-associated spontaneous coronary artery dissection (P-SCAD), their angiographic and multimodal imaging findings, acute phase treatment, and outcomes. Engineering dynamic pathway regulation using stress-response promoters. Biochemical-immunological hybrid biosensor based on two-dimensional chromatography for on-site sepsis diagnosis. Clinical and hematological studies in a family with hemoglobin Vancouver. These alkaloids are structurally related to the neurotoxic alkaloid methyllycaconitine (4) and may be important in establishing the toxicity of low larkspurs to cattle. 20 patients, aged 53 (SD 6) years, undergoing electrophysiological study for investigation of idiopathic paroxysmal atrial fibrillation (seven patients) or for routine follow up after successful catheter ablation of supraventricular tachycardia (13 patients). Contrasting disease and nondisease protein aggregation by molecular simulation. Diet and nutrition may be as one of important factors in prevention or treatment of various cancers. A technique is described for producing a normal course of circulation in these cases.

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Changes in their parameters appear to account for features observed in processes of motor learning and motor recovery from stroke. Changes in milk is 600 mg of neurontin a lot quality after the introduction of automatic milking systems on 28 Dutch dairy farms were examined and observations were compared with milk quality characteristics on two groups of farms milking either two (49 farms) or three times (28 farms) per day in a conventional milking parlor. The motor threshold to single transcranial magnetic shocks, but not to electric stimuli, was higher in the epileptic motor cortex than the normal left motor cortex. At the caudal limit of the corpus callosum, the gyrus curves around the splenium, turns laterally and forms a region called the isthmus that links the cingulate and parahippocampal gyri. The problems of surgical tactics in the treatment of pancreatic pseudocysts and related complications.

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Increased glycemic variability is independently associated with length of stay and mortality in noncritically ill hospitalized patients. New approaches to the treatment of OA that induce regeneration and repair of cartilage are strongly needed. Contribution on double contrast arthrography for the indication of rearthrotomy of the knee joint. The obstetric unit in King Edward VIII Hospital, a large tertiary referral centre in Kwa-Zulu Natal, South Africa. This type of management is the result of sociological changes and allows a reduction of the cost. A case is presented in which a rare underlying condition (non-ketotic acidosis) and a rare cause of cutaneous injuries collide. Biochemical and molecular biological evidence indicates that endothelin (ET)-1 and its receptors are selectively upregulated in the lung during exposure to hypoxia, while functional evidence indicates that ET-1 is a major mediator of hypoxia-induced pulmonary vasoconstriction and vascular remodeling. They had Class I skeletal pattern and upper arch crowding more than 5mm.

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Hemolytic anemia with aortic stenosis resolved by urgent aortic valve replacement. Nomogram-Derived Prediction of Postoperative Ileus after Colectomy: An Assessment from Nationwide Procedure-Targeted Cohort. Complex biological interactions in a cyanobacteria-mediated dulcolax suppository 10 mg bisacodyl guild are proposed here, which explains composition and dynamics in bryophyte and lichen-dominated epiphytic communities. Consequently, highly sensitive assays have been already used in progress for detection of MRD in the patients with MM, such as multiparameter flow cytometry, polymerase chain reaction(PCR), next-generation sequencing and positron emission tomography/computed tomography. Symphysis fundus height measurements during labour: a prospective, descriptive study. Aggrecan degradation involves proteolytic cleavage of the core protein within the interglobular domain. There were no objective responders, two patients remained stable, two were not evaluable for response and the other 12 progressed on treatment. In the present investigation, we studied their in vivo immunomodulation of an HIV-1-specific DNA vaccine candidate (pCMV160/REV) constructed with the cytomegalovirus (CMV) promoter-conjugated HIV-1 env and rev DNA plasmids. In OJ14 with LPS administration, ATP contents significantly decreased and alanine aminotransferase levels increased. Within the limitations of the existing literature, this systematic review of treatment outcomes found that initial endodontic treatment had a high long-term survival rate, equivalent to replacement of a missing tooth with an implant-supported restoration.

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Influence of harvest date within the season and cold storage on cherimoya fruit ripening. Recently the National Committee for Clinical Laboratory Standards (NCCLS) approved the agar dilution method as the test of choice for testing H. Thus, it was demonstrated, for the first time, that TCR avidity played an essential role in differentiation of self-antigen-reactive T cells, through the success of establishment of two distinct WT1-CTLs with a difference in only TCR avidity under the identical genetic background. This correlation reveals the remarkable effect of the structural imperfections of the membranes on ion transport and particularly the scaling behaviors of both diffusive and electrokinetic ion transport in graphene-based cascading nanochannels as a function of channel size from 10 nm down to subnanometer. The participation of this muscle system in the normal functioning of the Eustachian tube-middle ear system in man, and the problems inherent in the development of animal models simulating the physiology of the physiology of the human system, are discussed. To investigate the anti-apoptotic mechanism of leptin in non-small cell lung cancer. Myocardial infarction in the third trimester of pregnancy secondary to an aortic valve thrombus. The circadian rhythm of miR-34a was evaluated in cholangiocarcinoma and H69 cells.

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Toll-like receptor (TLR) 4 is an important protein of human innate immunity. Salt appetite consequent on sodium depletion in the suckling rat pup. To examine potential detrimental long-term effects of acute diet-induced weight loss on visceral adiposity, insulin resistance, cortisol, and adipokines in obese individuals at risk for type-2 diabetes. Three patients are reported who had focal limb muscle weakness associated with zoster infection. In this scenario, oxidative stress plays a critical role causing direct damage to the central nervous system and activating metabolic cascades leading to apoptosis and inflammation. Among coagulation disorders are congenital haemorrhagic or thrombotic conditions, acquired blood coagulation disorders--combined in the vast majority of cases-- and associated with pregnancy, severe internal diseases and surgery related diseases, severe injuries, wounds, burns, malignancies, systemic connective tissue diseases, inflammatory bowel disease, and a number of other diseases.

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In addition, we compared weights obtained with electronic weighing beds with those obtained with a regular calibrated scale on ICU discharge. In the availability of an extensive set of risk factors, there was little added effect of MR-proADM in risk prediction of CV and all-cause mortality. Urinary mercury levels in females: influence of skin-lightening creams and dental amalgam fillings. The expression of genetic variation for development time is somewhat more complex when temperature extremes are considered. The respondents were very appreciative of the instruments and found it valuable to have the opportunity to talk about these aspects of their condition. Smoking as a risk factor for diabetic nephropathy: a meta-analysis. Furthermore, while supercomplex III2 IV1 is abundant in D2, none is detected in B6. To assess the attitudes cost of biaxin antibiotic of medical students to autopsy, 6th year students in the Medical Schools located in Istanbul, Edirne and Bursa in Turkey were asked to participate in a questionnaire.

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