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Alparazole (Alprazolam)

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Alparazole is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alparazole, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alparazole is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Almee, Alpradol, Alpram, Alpramax, Altin, Alzoact, Andep, Anxico, Berest, Besquil, Dexolam, Erazol, Flunix, Fluxin, Poize, Pranol, Prazil, Prosanti, Resto, Rezolam, Sertamax, Synozolam, Tenolam, Tranisol, Welnorm, Zamitol, Zedel, Zodia, Zolipax, Zolorel, Zopain

Similar Products:
Alprostadil, Provigil, Nexium, Ditropan, Zithromax, Terramycin, Antivert, Zebeta, Aldara, Zyvox, Durogest, Orbil, Pramace, Nebispes, Sugafen,

Also known as: Alprazolam


Alparazole is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alparazole is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alparazole if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alparazole or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alparazole. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


Take Alparazole exactly as prescribed by your doctor. Follow all directions on your prescription label. Never use Alparazole in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in treating your symptoms.

Alparazole may be habit-forming. Never share Alparazole with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Do not crush, chew, or break a Alparazole extended-release tablet. Swallow the tablet whole. Call your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms. Do not stop using Alparazole suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alparazole XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alparazole XR dosage information

Side effects

The most common side effects associated with Alparazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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Cardiac tamponade can be a lethal complication in the cardiac catheterization laboratory. Immunotherapy of cancer (some immunological problems in cancer therapy). Relations with cystic fibrosis are well established but congenital bilateral absence of vas deferens discovered during infancy is an exceptional situation that requires genetic investigations to show evidence of a likely underlying cystic fibrosis. Interestingly, Mig1, a downstream target of Snf1 kinase, is phosphorylated in glucose-stressed but not sodium-stressed cells. Genetic and structural organization of the aminophenol catabolic operon and its implication for evolutionary process. Diabetes is associated with many microvascular and macrovascular complications. Our results support the hypothesis that when present, neuropsychological impairment is already present at diagnosis and that the most statistically significant factors, which might be related with cognitive deficits in the preoperative as well as in the postoperative period, are tumor infiltration of the brainstem, the severity of hydrocephalus, and a histological diagnosis of MB. The effect of the excimer laser (308 nm) parameters on transmyocardial revascularization (TMR) channels is not well defined. Authorization, institutional services, hospital-based practices and cooperation in the hospital--from the perspective of the hospital-based physician.

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Multichannel optical communications using tunable Fabry-Perot amplifiers. Coping style, levels of disclosure regarding serostatus, and formation of legal custody plans were similar across intervention conditions. We also identify new functional modules in the combined network, which cannot be detected in the metabolic network only. An approximate solution at the critical point of the spherical to axially deformed shape phase transition in nuclei is presented. Dowling-Degos disease and hidradenitis suppurativa: Co occurrence or association?. In the applied one way mixed lymphocyte cultures (MLC) a significant proliferative response was obtained when peripheral blood lymphocytes were cultured with mitomycin treated synovial fluid cells. Foodborne illness is a significant public health issue in most countries, including Australia. The technique is indicated in patients who cannot be given surgical or radiation treatment and in cases of asphyxial syndrome requiring faster deobstruction than is obtainable with radiation treatment. Nine semi-structured interviews were conducted in February 2010. The second group received oral enalapril on day 28 after the formation of scars.

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Although significant information has been reported on the molecular mechanisms by which Sp1-like activators function, relatively little is known about mechanisms for repressor proteins. Community-acquired Klebsiella pneumoniae liver abscess: the London experience. Two months after initiation of therapy, high density lipoprotein cholesterol levels were significantly elevated, and LDL cholesterol levels were reduced, although not normalized. For the personnel, effective doses were generally higher than personal doses by a factor between 1.5 and 4.8 depending on the radiation protection situation. In this case report we describe for the first time in the literature bilateral femoral neck fractures in a patient following minimal trauma after a simple mechanical fall. An autopsy revealed that the urinary bladder tumor was a signet ring cell carcinoma, metastasized from gastric remnant carcinoma. Conversely, the analysis of suppression effects in the narrow-band frequency components of TEOAE indicated that the subjects involved showed no relevant damage to the efferent regulatory mechanisms that control the cochlear activity, neither through the cochlea as a whole, nor in limited cochlear regions. Nasal polyp epithelial cells were obtained from patients and stimulated with Alternaria, Aspergillus, and Cladosporium. For single biphasic charge-balanced pulse, an increase in spike threshold was typically produced by inclusion of one or both of these channel types.

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Rhodium-catalyzed intermolecular C-H amination of simple hydrocarbons using the shelf-stable nonafluorobutanesulfonyl azide. Our results suggest a novel dual role of fibrin in epidermal healing. Reactive oxidant species (ROS) are highly reactive molecules produced by several cell lines including platelets and serve as second messenger for intracellular signaling. Interactive computer programs are seen as a potential vehicle for weighting the variables involved in the decision and for storing, manipulating, and delivering the necessary data funcand information. Psychiatric assessments of these children and their families are recommended as a routine as they will identify potential ethical dilemmas, and will allow for the detection and management of the psychosocial and neuropsychiatric consequences of AIDS. The organization of adrenocorticotropin (ACTH)-immunoreactive (IR) cell bodies and fibers in the cat forebrain is described.

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TGF-beta and related factors have at their disposal a repertoire of such receptors, a feature that could account for their multifunctional nature. Computed tomography and magnetic resonance imaging of the equine head. They possess a common origin from the cells derivided from the neural crest, that today gathered on the term of neuroendocrine diffuse system (SNED). Expression of claudin-2 was assessed by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and Western blot. Human cranial anatomy and the differential preservation of population history and climate signatures. Into the patent ductus arteriosus, using flexible myocardial biopsy forceps, we placed two large 0.052-inch Gianturco coils, which were easily used as multipurpose vascular occlusion coils. However, no ideal material for dural repair in neurosurgical procedures has been identified.

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The present study was undertaken to develop passive immunotherapy monoclonal antibodies (MAbs) against periodontitis, which are capable of inhibiting virulency and were constructed through the immunization of outer membrane vesicles (OMV) fraction of fimAII strain, TDC60, using mouse hybridoma technology. A sensitive algorithm for automatic detection of space-time alternating signals in cardiac tissue. Bacterial quorum sensing (QS) is a cell-cell communication and gene regulatory mechanism that allows bacteria to coordinate swarming, biofilm formation, stress resistance, and production of toxins and secondary metabolites in response to threshold concentrations of QS signals that accumulate within a diffusion-limited environment. Computer- assisted corneal topography devices are valuable diagnostic tools for the diagnosis of subclinical keratoconus and for tracking the progression of the disease. HtrA1 is a serine protease homologue to the bacterial serine-protease HtrA, also known as DegP, a heat shock-induced envelope-associated serine protease.

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Emergency outpatient services in the city of Berlin: Factors for appropriate use and predictors for hospital admission. Plasmid vectors have been widely used for DNA vaccines and gene therapy. The continuous infusion of thoracic epidural bupivacaine was shown to reduce supraventricular tachyarrhythmias. Few data are available on left ventricle (LV) performance in young athletes with bicuspid aortic valve (BAV), where a pattern of mild aortic insufficiency is relatively frequent, and the ejection fraction (EF) is often normal for a long time. I tried to propose an algorithm for stepwise diagnosis and treatment from uninvestigated dyspepsia to functional dyspepsia in clinical practice in Japan. Fatigue was associated with additional barriers such as physical deconditioning, social isolation, and the difficulty of making exercise a routine. An elliptical phantom was scanned with four automatic tube current modulation techniques after acquisition of localizer radiographs in the horizontal and vertical directions with the phantom center shifted from the gantry isocenter in the vertical direction. We report the development of a real-time PCR assay for the species-specific identification of A. Temperature-dependent development of Elasmopalpus lignosellus (Lepidoptera: Pyralidae) on sugarcane under laboratory conditions. In addition, selection of both well and poorly expressed clones from two libraries further elucidated the impact of structural bias.

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TB tracer teams in South Africa: knowledge, practices and challenges of tracing TB patients to improve adherence. Diurnal and seasonal changes in the environmental conditions are important for the normal course of these physiological processes and, similarly to their mild irregular alterations, for stress adaptation. Spleens harvested from mice infected 20 to 30 days earlier with 10(8) M. The aim of this short review is to provide a cell biological framework within which emerging data on the molecular basis of oomycete-plant interactions may be placed. A polarization anisotropic image of the SHG light indicated that wrinkle direction in UVB-exposed skin is predominantly parallel to the orientation of dermal collagen fibers. In this review, we summarize the current knowledge on TLR3 signalling in DCs and highlight similarities and differences with respect to other cell types. In addition, repeated immobilisation resulted in decreased relative thymus weight, increased relative adrenal weight, elevated corticotropin-releasing factor (CRF) mRNA levels in the hypothalamic paraventricular nucleus (PVN), and down-regulation of glucocorticoid receptor gene transcription in hippocampus CA1. CWE, at a dose of 500 mg/kg (p.o.), signifi cantly increased the time spent in the open arms of the EPM compared to a vehicle-injected control group.

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Marked axonal regeneration was observed when the nerve biopsy was delayed after withdrawal of the drug, Micro-angiopathy secondary to the formation of concentric lamellae from the basement membrane was observed in five patients suffering from chronic hypoxemia. Inclusion criteria included patients receiving warfarin therapy whose international normalized ratios (INRs) were elevated above normal values on the day of surgery. Effect of SIN-1 on the synthesis of leukotrienes in human polymorphonuclear cells. Moreover, some evidence of the contribution of different reaction routes is provided, which led us to propose a plausible multipathway mechanism consistent with all of the results described. In virions, in addition to the main structural polypeptides, protein components with molecular weights about 100 kD were found which, most likely, were aggregates of E1/E2 glycoproteins, and 40 kD, a product of E1 protein degradation. Plasma total cholesterol concentration was measured to derive an alpha-tocopherol/cholesterol ratio.

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In relation to the well-described metabolic disturbances in PCOS, the insulin gene variable number tandem repeat (VNTR) appears to be a promising candidate, at least in populations studied in the UK. There are relatively few studies specifically concerning CPE and dementia care. In the 1980s Goldbeter and Koshland showed that such cycles can exhibit non-linear input-output relations when the enzymes are saturated by their substrates, which may facilitate signal processing. However, combined administration of clorgyline (10 mg/kg) and selegiline (3 mg/kg) reduced freezing significantly, as well as combined administration of clorgyline (10 mg/kg) and lazabemide (10 mg/kg), Ro 41-1049 (30 mg/kg) and selegiline (3 mg/kg), or Ro 41-1049 (30 mg/kg) and lazabemide (10 mg/kg). The role of insulin growth factor-I as a survival factor in human hepatic stellate cells needs to plavix safe dose range be substantiated.

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In order to assess these factors, we reviewed what is currently known about the psychological impact of undergoing bilateral prophylactic mastectomy. Psychosocial measures of coping style, negative affect, social support, stress, and health behaviors were completed before ABP measurement. While antidiabetic medications, with newer anti-obesity medications and interventional bariatric procedures have shown some promising benefits, diet and therapeutic lifestyle change remains the mainstay of management to improve the metabolic profile of individuals with glucose dysregulation. Golgi staining of prelimbic pyramidal neurons revealed that TBI causes a significant shortening of layers V/VI basal dendrite arbors by 4 months post-injury, as well as an increase in the density of both basal and apical spines in these neurons. Overuse syndromes in the wrist or hand can occur from repetitive use of the wrist and hand or from recurrent direct trauma to the hand area. Parenting styles are characterised by the two dimensions parental attitudes and rearing practices. In vitro generation of helper T cells and suppressor T cells that regulate the cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells. Preoperative radiotherapy and local excision of rectal cancer with immediate radical re-operation for poor responders.

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Major differences in the characteristics of suicide attempters with and without a prior history of suicide attempts suggest that these are independent subgroups of attempters. The response to insulin stimulation in isolated hepatocyte in rats with selenium supply was similar to that in the control group, and both groups had higher response than those with high-fat diet. Binding of each factor can be competed out selectively by the appropriate double-stranded oligonucleotide, indicating that this binding is not strictly cooperative. An overwhelming predominance of presumptive Vibrio harveyi and Vibrio anguillarum was price of cleocin 100 mg observed in post larval rearing tank water, MBV infected and uninfected post larvae. Positive health practices and depressive symptoms among high school adolescents in Oman. One simplified point source infiltration model with the parameters opening film hole rate, film hole diameter, soil clay particle content, and soil bulk density was established, and tested by infiltration experiments with the typical soils from Loess Plateau. The ability of Coenurus cerebralis cyst fluid to cause primary blastic transformation of naive neonatal bovine lymphocytes is demonstrated. Incidence of post-cataract endophthalmitis at Aravind Eye Hospital: outcomes of more than 42,000 consecutive cases using standardized sterilization and prophylaxis protocols. knowlesi sporozoites, 1 of 12 experimental monkeys was completely protected and the mean parasitemia in the remaining monkeys was significantly lower than that in 4 control monkeys. Playing-related musculoskeletal disorders (PRMDs) are common in musicians and interfere with the ability to play an instrument at the accustomed level.

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Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins. Total acetaminophen consumption was lower in group B than those in group S. Silencing was evaluated by Western blot using an antibody against the EhCP112 recombinant protein. Beside this, a sufficient quantity of examined triterpene substances is also obtained for continuation of their further analytical analysis. We conclude that the central and pressor effects of angiotensin II are critical for T-cell activation and development of vascular inflammation. The model is applied to predict a generic fishery-induced evolutionary response and allows assessment of climate change impact on MRNs. This is the first study to suggest the importance of exogenous viral infection in chemically induced colonic carcinogenesis. Transformation to produce transgenic plants is part of this toolkit, enabling a spectrum of approaches to study gene function: including knockdown, overexpression, reporter genes for gene expression, and proteins tagged with fluorescent proteins such as GFP. Self-assembled pi-stacks of functional dyes in solution: structural and thermodynamic features. Experiment 1 showed that both men and women underestimated the time-to-arrival of full-cue looming sounds.

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The possibility that the 70-bp repeats are important in the initial steps of the recombinational events was illustrated by a rearrangement involving a 70-bp repeat array. The effect of letrozole with misoprostol for medical termination of pregnancy on the expression of steroid receptors in the placenta. Ring-enchancement in multiple sclerosis: marker of disease severity. Data on socio-demographic factors and diarrhoea status were obtained by interviewing all 214 with ART and 164 without ART. The ease with which loss of expression of the markers can be monitored has allowed us to make observations on the stability of proviral genes.

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Electrical signals recorded from the brain cover a wide range of amplitudes, frequencies, and spatial scales, from spikes and local field potentials (LFP) inside the brain to electrocorticograms (ECoG) and electroencepalograms (EEG) outside. Because SNL-CM and GDNF-like molecules stimulated the formation of spermatogonial chain length differently, we purified components of SNL-CM to identify the additional contributing factor(s). Evaluation of intensive adjuvant chemotherapy in gastric cancer using life expectancy compared with log-rank test as a measure of survival benefit. These effects were contrasted on silencing glucose-6-phosphate dehydrogenase, the key enzyme in pentose phosphate pathway, or inhibiting Akt. Finally, experimental results which verify the analytical do dulcolax pills expire predictions are also presented. Rather, BHRF1 may act either by binding preferentially the most lethal form of Bim or by acting catalytically on Bim to block apoptosis. Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells. Enhancement of mtDNA repair in oligodendrocytes provided protection from reactive oxygen species- and cytokine-induced apoptosis.

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The present study was conducted to determine whether the protective effects of DTG lead to improvements in behavioral functioning. The small size or submucosal location of the lesion often results in a delay in correct diagnosis and treatment. The aim of this study was to validate the Seattle Heart Failure Model (SHFM) in patients with advanced heart failure (HF). The biliary tract excretion of three cephalosporins, cefazolin, cephaloridine, and cephalothin, was compared in patients with biliary tract disease. The presence of DMSO resulted in small or no increases in brain levels of DA or its metabolites.

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5-hydroxyindoles and kinins in the carcinoid and dumping syndromes. Determination of ketobemidone and its metabolites in plasma and urine using solid-phase extraction and liquid chromatography-mass spectrometry. Therapist-aided exposure for women with lifelong vaginismus: a replicated single-case design. This report provides new in vivo information of expressed genes that can be useful for further investigations of the molecular mechanisms in focal localization of atherosclerosis. Based on these data, patency of the APD was estimated from its terminal shape in patients with post-ERCP pancreatitis.

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Study of hypothermia on cultured neuronal networks using multi-electrode arrays. In contrast, the formation of an absorbance change at 683 nm that accompanies quenching displayed first-order kinetics. In addition, the residuals of the spatial regression model are no longer autocorrelated, which indicates that the analysis produces more reliable results. The DIC score, sepsis-related organ failure assessment (SOFA) score, prothrombin time (PT) ratio and thrombin-antithrombin complex level were significantly high in the patients who did not recover from DIC. Despite beta cell mass recovery and normal arginine-induced insulin secretion, GSIS and pancreatic insulin content were profoundly lowered in ZF-Px rats.

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Medication with Ursodeoxycholic acid (UDCA) and vitamin E was performed in children whose liver functions did not improve or their weight reductions were not successful. One hundred and fifty-one phylotypes from 810 clones were identified to eight phyla, and each sample contained an average of 25.9 phylotypes. A family of integral membrane proteins, termed soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins, constitute the key machineries of these different membrane fusion events. It was the aim of this study to examine the incidence of perioperative events in an elderly population of patients with severe AS undergoing repair of hip fracture as compared with controls without severe AS. We have shown previously can u drink alcohol while taking claritin that valosin-containing protein (VCP) physically and functionally targets the ubiquitinated nuclear factor kappaB inhibitor, IkappaBalpha to the proteasome for degradation. Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy. Their surfaces were characterized by zeta-potential measurements, after which their properties including swelling, degradation, drug release, and cytotoxicity were also investigated using in vitro models. Occipital neuralgia is a form of headache that involves the posterior occiput in the greater or lesser occipital nerve distribution.

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Current models of the pathogenesis of osteoarthritis (OA) would indicate that proteolytic modification of the cartilage extracellular matrix is important in the development of irreversible joint destruction. We have developed two integrated and freely available web-tools for PCR based methylation analysis. The neuropeptides orexin A (OXA), neuropeptide Y (NPY) and galanin (GAL) have been shown to play a role in the regulation of food intake in mammals. This construct is vital to decision making in intense, dynamic environments. None of the current biomarkers have been shown to be better than exhaled NO in asthma. Studies on the microsomal electron-transport system of anaerobically grown yeast. Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential. To characterize the role of SigM in Mycobacterium tuberculosis, a sigM deletion mutant was generated by allelic exchange in the virulent CDC1551 strain.

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