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Alpazepam (Diazepam)

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Alpazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peens). It affects chemicals in the brain that may be unbalanced in people with anxiety. Alpazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Alpazepam is sometimes used with other medications to treat seizures. Alpazepam may also be used for purposes not listed in this medication guide.

Other names for this medication:
Almpose, Alpazepam, Alzepam, Anxol, Calmod, Calmpose, Calmtack, Campin, Camrelease, Depresom, Depsonil, Diaclam, Diaze, Diazecalm, Diazeco, Dipax, Direc, Dizapam, Dizep, Elpam, Elpose, Hypose, Imilor, Imipam, Imlor, Juniz, Karpam, Lakpam, Neomesmar, Nindral, Osopose, Paciquil, Paxum, Placidox, Ralium, Silprex, Sleecalm, Sparlium, Syziral, Valrelease, Verzepam, Zeopse, Zycalm

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Also known as: Diazepam


Alpazepam (diazepam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that diazepam works by enhancing the activity of certain neurotransmitters in the brain.

Alpazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms and stiffness.

Alpazepam is sometimes used with other medications to treat seizures.


Take Alpazepam exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Alpazepam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Alpazepam should be used for only a short time. Do not take this medicine for longer than 4 months without your doctor's advice.

Do not stop using Alpazepam suddenly, or you could have increased seizures or unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Call your doctor at once if you feel that this medicine is not working as well as usual, or if you think you need to use more than usual. While using Alpazepam, you may need frequent blood tests at your doctor's office.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.

Overdose symptoms may include extreme drowsiness, loss of balance or coordination, limp or weak muscles, slow breathing, or coma.


Store at room temperature away from moisture, heat, and light. After you have stopped using this medicine, flush any unused pills down the toilet.

Keep track of the amount of medicine used from each new bottle. Alpazepam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Alpazepam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Alpazepam is contraindicated in patients with a known hypersensitivity to Alpazepam and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age. Alpazepam is also contraindicated in patients with myasthenia gravis, severe respiratory insufficiency, severe hepatic insufficiency, and sleep apnea syndrome. It may be used in patients with open-angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute narrow-angle glaucoma.

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We aimed to show that P-wave duration (PWD) and P-wave area under the curve (PWAUC) changes in patients undergoing PLAI can be measured using signal-averaged electrocardiogram (SAECG), and that reversal of these changes in patients with RAAs can be used to noninvasively detect reconnection. Ctk complex-mediated regulation of histone methylation by COMPASS. However Aln increased whereas Dmab suppressed osteoclast number and surfaces. It may contribute to atopic asthma by influencing the resolution of lung inflammation and prolonging the repair response of damaged bronchial epithelial cells. Patients were divided into the following categories: primary or revision rhinoplasty, alarplasty, and ethnicity. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell death rate through induction of mitochondria-mediated, caspase-dependent apoptosis. The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). To ascertain the cost-effectiveness and the benefit-cost ratios of a community-based hepatitis B vaccination catch-up project for Asian American children conducted in Philadelphia, Pa, from October 1, 1994, to February 11, 1996.

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Locally administered monoclonal antibodies to lymphocyte function-associated antigen 1 and to L3T4 prevent cutaneous graft-vs-host disease. The critical function of the pathway was demonstrated in the hereditary genetic disorder Anhidrotic Ectodermal Dysplasia (EDA), which is characterized by defective formation of hair follicles, sweat glands and teeth. The impact of robotic rehabilitation in children with acquired or congenital movement disorders. Our findings suggest that signaling from cytokines initiates the differentiation program, but that the selective action of death effectors determines the fate of differentiating T-helper cells, and thus, the ultimate balance between T-helper subpopulations. Gamma-hydroxybutyrat (GHB)-dependence and -withdrawal in the case of previous alcohol dependence. Analysis of the reporter activity in vivo revealed that the activities of nuclear factor-kappaB and 26S proteasome were differentially activated in slow and fast muscles, suggesting muscle type-specific mechanisms may be utilized. Paste electrodes have been constructed using single-wall carbon nanotubes mixed with mineral oil.

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Although the level of CT and MRI devices per population in Israel is low in comparison to the Western world, the devices operate intensively. The estimation of HIV incidence and ART exposure is crucial to disentangle the concurrent impact of prevention and treatment programs on HIV prevalence. Both transmurally-stimulated and punctate-stimulated atria were employed to examine neurogenic and direct cardiac actions of the Ang, respectively. These findings suggest that a vasogenic oedema rather than a cytotoxic oedema may play a pivotal role in FK506 neurotoxicity pathogenesis. Finally, the depressed group showed significant CSF volume reductions in the orbitofrontal cortex relative to the comparison subjects. Evaluation of antinociceptive, antinflammatory activities and phytochemical analysis of aerial parts of Urtica urens L. Background-subtracted cyclic voltammograms of the naturally-evoked signals matched those of electrically-evoked dopamine measured at the same recording sites. Furthermore, systemic acquired resistance induced in remote leaves of Xanthi-nc tobacco is also associated with stimulated MDA signals indicative of a microoxidative burst.

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In contrast, Bach1-deficiency did not affect extent of mouse paw edema induced by carrageenin, which enhances vascular permeability by activating kinin release. This result was also confirmed when the analysis was restricted only to the cases where both the primary tumor and the autologous lymph node metastasis were available. Participants represented state and local health departments, community-based organizations, national research/advocacy organizations, and academic institutions across the country. An additional mechanism to remove dsRNA from cells may involve hyper-editing of dsRNA by ADARs, followed by targeted cleavage. Alcohol problems and all-cause mortality in men and women: predictive capacity of a clinical screening tool in a 21-year follow-up of a large, UK-wide, general population-based survey. To evaluate the cost-effectiveness of tertiary referral care for ovarian cancer patients in the Netherlands. On the processing of semantic aspects of experience in the anterior medial temporal lobe: an event-related fMRI study.

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With improved patient care, better diagnosis, and more treatment options after tumor recurrence, outcomes after fluorouracil (FU) -based treatment are expected to have improved over time in early-stage colon cancer. Pre-tested questionnaires were administered after ethical considerations. Our results do not support large increases in eating frequency, snacking, or evening eating by the American population from 1971 to 2002. Long-term results after surgery for duodenal ulcer were not very encouraging, so we suggest for these patients a medical treatment and just in exceptional cases of refractory ulcers we would recommend a surgical procedure with minimal long-term complications. Transient inhibition of the cell cycle regulator p21 results in significant acceleration of mesenchymal stem cell proliferation without promoting spontaneous cellular differentiation. Demyelination of nerve fibers in the central nervous system caused by chronic exposure to natural hydrogen sulfide-containing gas. Three hundred and thirteen pregnant mothers were randomly assigned to receive BCSO (151) or olive oil as placebo (162).

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Differences in personal exposures to NO(2) were analyzed between sub-populations stratified by microenvironment, behavioral, socioeconomic and demographic factors. We describe how the use of dexmedetomidine for sedation during awake fibreoptic intubation also facilitated self-positioning before surgery in a patient with a cervical cord compressive lesion and raised intracranial pressure undergoing excision of a cerebellopontine angle lesion in the lateral position, without any adverse neurological outcome. Growth of Venezuelan encephalitis virus and disapperance of coxsackie A, Rous sarcoma, herpes simplex and vaccinia viruses following inoculation of Aedes aegypti and other mosquitoes. The ESR spectrum of the conjugate base of the 4-ethoxyaniline cation radical, the neutral 4-ethoxyphenazyl free radical, was obtained at pH 11-12 by the oxidation of p-phenetidine with potassium permanganate. Ultrasonic treatment is now an usual proceeding technique for the extraction of some bioactive constituents. In this work, simulations based on Monte Carlo ray-tracing were performed for models of luminescent microparticle materials embedded in skin.

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A population-based study was conducted using cancer registry and administrative data. Akt activates nuclear factor kappa B (NF-kappaB), which transcribes genes important for cell survival, invasion, and metastasis. A growing body of evidence suggests that promotion of DNA double-strand break repair by homologous recombination (HR) may be the means by which BRCA1 maintains genomic stability, while a role of BRCA1 in error-prone nonhomologous recombination (NHR) processes has just begun to be elucidated. After licensure of the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States in 2000, the incidence of pediatric pneumococcal meningitis decreased significantly. We examined the differences between the concentrations of chemical elements in caries-changed primary teeth and permanent ones with a division into the root and the crown. In contrast, hippocampal and inferior prefrontal activity predicted successful retrieval of newly formed inter-item associations. Most anaphylactoid reactions occur at the start of acetylcysteine treatment when concentrations are highest. Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter. The API specification derives from the OMG Lexicon Query Services interface specification as a foundation and defines mechanisms for browsing, querying and import terminological content. The integrity of the seal was evaluated for 5 min at 1, 7, 30, and 180 days.

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Methionine, lysine, cystine, leucine, aspartate and glutamate have been tested individually and in combination in different models of either normo or hypercholesterolemic animals and found to be able to modify blood cholesterol and/or LDL cholesterol and/or HDL cholesterol. cinerea appressoria are required for a successful penetration process. Accurate wound debridement is important, and while many methods exist, surgical debridement is currently the gold standard with material costs at approximately pound 140. Cross-talk between microtubule networks and sites of cell-matrix and cell-cell adhesion has profound impact on these structures and is essential for proper cell organization, polarization and motility. A novel mechanism for utilization of extracellular AMP in Vibrio parahaemolyticus. Three dogs and four cats were similarly dosed using a liquid preparation of the same antibiotic. This paper describes methods used to try to grow NoV in vitro in two laboratories.

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Finally, what microbial system could be used to transform energy resources into the targeted biofuel molecules. Bacterial inclusion bodies, while showing intriguing amyloid-like features, such as a beta-sheet-based intermolecular organization, binding to amyloid-tropic dyes, and origin in a sequence-selective deposition process, hold an important amount of native-like secondary structure and significant amounts of functional polypeptides. Both MA3 domains are required to efficiently compete with the C-terminal domain of eIF4G (eIF4Gc) for binding to eIF4A whereas a single MA3 is sufficient to inhibit translation. This research provides a basic understanding of CAP toxicity to aquatic organisms. Specifics of surgical treatment of stomach cancer in patients 70 years of age and older.

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Here we aim at evaluating the influence of ionic interactions and how these intertwine with the structural dynamics, stability and activity of LPO. Spontaneous regression in size or complete disappearance of an aneurysm is a known phenomenon, more commonly noted in giant intracranial aneurysms. The paucity of symptoms and signs in the right lower quadrant does not exclude appendicitis. The literature and the two case reports support the use of hyperbaric oxygen therapy in the treatment of acute hydrogen sulfide toxicity. When montmorillonite is combined with humic acid or chitin, the aggregation of montmorillonite was effectively inhibited. Selecting artificial teeth for edentulous patients is difficult when pre-extraction records are not available. Different mechanisms of mitotic instability in cancer cell lines. Separation of a subcellular fraction enriched with acridine orange cytoplasmic granules.

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The patients also received a single oral test dose of 75 mg of zimelidine during an initial placebo week. There were virus signals in hepatocytes in columnar epithelium and lamina propria cells of jejunum villi, but no significant pathology was demonstrated in both sites. Nonoperative management of the spleen has been the conventional approach for dealing with blunt splenic injury in children for 25 years. The former relies on the generation of graphene from suitably designed molecular building blocks undergoing chemical reaction to form covalently linked 2D networks. The aim of the present work was to study NO metabolism in platelets from pregnant women with GDM. The molecular causes of auditory neuropathy spectrum disorder (ANSD) are not well known.

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Treatment of unstable thoracolumbar spinal injuries--determination of its present status and a preliminary report on transpedicular stabilization. pneumophila intracellular growth is the Dot/Icm type IVB translocation system. This model includes alveolar, interstitial, and hilar lymph node compartments. Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging. Tomographic techniques play a crucial role in imaging methods such as transmission electron microscopy (TEM) due to their unique capabilities to reconstruct three-dimensional object information. Using the databases of the human genome project we elucidated the exon-intron structures of the human VPS10-receptor genes. Children with moderate-to-severe obstructive sleep apnea and the phenotype of hypertrophic tonsils have reduced morning serum cortisol levels and potentially decreased glucocorticoid inhibitory effects on tonsillar growth.

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Clinical and histopathological characterization of cutaneous melanomas in the melanoblastoma-bearing Libechov minipig model. Epigenetic aberrant methylation of tumor suppressor genes in small cell lung cancer. Molecular imprinted photonic crystal hydrogels for the rapid and label-free detection of imidacloprid. Artificial spider dragline silk is currently prepared by a recombinant technique or chemical synthesis. This includes insertion of operator repeats and selectable markers into these BACs as well as targeted insertion or deletion of BAC sequences. From the temperature profile along the centerline of the acupuncture needle, the temperature is seen to decrease rapidly from the burning moxa section (200 degrees C) to the skin surface (36 degrees C). Sex and the clinical value of body mass index in patients with clear cell renal cell carcinoma. NOV/CCN3, a founder CCN member, is expressed in the developing central nervous system but its functions during neural development have not been studied yet. Chromosome stabilizing structures amethopterin in mitotic Indian muntjac (Muntiacus muntjak) cells.

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To our knowledge, this is the largest reported series of radiological description of spinal biaxin xl generic ochronosis, and emphasizes the contribution of the spine radiograph in the diagnosis and staging of the disease. Diagnosis based on clinical criteria alone is, therefore, unacceptably unreliable. A syndrome has been described in which hypogammaglobulinaemia is associated with splenomegaly and haemolytic anaemia and also non-caseating granulomata in lymph nodes, liver, spleen and skin. Pseudoangiomatous stromal hyperplasia (PASH) is a benign localized fibrotic lesion in which clusters of spindle cells form cleftlike spaces, resembling ectatic vessels. One of 2 lines displayed a decrease in the number of osteoblasts, but in vivo bromodeoxyuridine labeling demonstrated that CHOP overexpression did not have an effect on osteoblastic cell replication.

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Infants receiving developmental care required less time on total parenteral nutrition, required less exogenous surfactant, and had less documented feeding intolerance. The purpose of this study was indocin 25 mg to determine the value of upright chest radiography and ultrasonography in demonstrating free air of perforated peptic ulcers. Asthmatic children who are taking low doses of ICS have higher HbA1c values than healthy children. Nutritional support: enhancing the quality of life of the terminally ill patient with cancer. This procedure should be well-known to general practitioners who are responsible for the follow up of these patients. Patient inclusion criteria were extremely variable, and studies were generally small with methodological concerns. During sensorimotor behaviors when the CT system may be active, cells having excitatory vs inhibitory receptive fields may participate in push-pull corticothalamic circuits that, acting together, selectively enhance sensory signaling in the thalamocortical system. The samples were analyzed for Cr and Yb, and values were plotted using 1- and 2-compartment nonlinear passage models and an algebraic model.

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Use of tranquilizers and of sedatives and hypnotics was less in the nursing home, whereas a larger proportion of patients were given antidepressant drugs. The small cell and lymphohistiocytic variants of anaplastic large cell lymphoma are commonly misdiagnosed as reactive lymphadenopathies. Observations on the Pathology of Rickets with Particular Reference to the Changes at the Cartilage-shaft Junctions of the Growing Bones: Harvey Lecture, February 16, 1939. Seasonal variationns in birthweights over a 10-year period (1972-81) are here compared with the local rainfall pattern. Pelvic pain in younger women is a critical public health issue experienced by a significant portion of the population. Porcine/chicken or human nephropathy as the result of joint mycotoxins interaction. Anti-HAV geometric mean concentrations (GMC), seroconversion rates, and GMC ratios (GMCR) of the three schedules were compared and reactogenicity was evaluated. From 1983 to 1998, 157 patients with Stage I or II cutaneous melanoma of the head and neck received elective regional radiotherapy after wide local excision of the primary lesion. Ice-age endurance: the effects of cryopreservation on proteins of sperm of common carp, Cyprinus carpio L. Previous studies have indicated that brain noradrenaline (NA) neurons in spontaneously (genetically) hypertensive rats (SHR) are implicated in the development of hypertension.

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Additionally, to increase the statistical power of topology tests, the same methods were applied to concatenated alignments of subunits of eight conserved macromolecular complexes. A logistic regression model based on the national mammography database format to aid breast cancer diagnosis. PSI surgery as an alternative to conventional TKA is not advisable. A linear matrix eigenvalue problem is obtained even when the medium is dispersive. The 100S ribosome purified from the cell in the stationary growth phase is composed of two transfer RNA-free 70S ribosomes, has two-fold symmetry, and is formed through interactions between their 30S subunits, where interactions between small subunit proteins, S2, S3 and S5, appear to be critical for the dimerization.

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The idea of our preliminary study was to analyze the potential lymphatic drainages in low-rectal cancer patients. A single-center institutional practice study of 215 patients from 2 separate consecutive randomized series undergoing surgery for presumed intermittent exotropia. The in vitro effects of OPN and its interaction with CD44 also were assessed. Amastigote DNA fragmentation was demonstrated using agarose gel electrophoresis. Role of combined 18F-FDG- cost of glyburide in us PET/CT for predicting the WHO malignancy grade of thymic epithelial tumors: a multicenter analysis. Data suggest that the alpha-hydroxymetabolite of metoprolol may contribute to the reduction in essential tremor. We analyze a duopolistic health care market in which a rural public hospital competes against an urban public hospital on medical quality, by using a Hotelling-type spatial competition model extended into a two-region model. However, a paucity of data exists on the long-term effects of infant soy formulas.

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The fistula was found on cystoscopic examination after the extrusion, from the cervix, of Mersilene tape from a Shirodkar cerclage placed 13 years earlier for management of cervical insufficiency. The best predictors of TUG at T3 in participants from acute care were the use of a walking aid in daily life, age, deficits in oral expression and the presence of depressive symptoms. Improved survival after out-of-hospital cardiac arrest in Copenhagen--secondary publication. Since oxidative stress contributes to the damage from MI-R we tested the hypotheses that: (1) HNG offers cardioprotection through activation of antioxidant defense mechanisms leading to preservation of mitochondrial structure and that, (2) the activity of either of a pair of non-receptor tyrosine kinases, c-Abl and Arg is required for this protection. Because the COX-catalyzed arachidonate cascade is an important source of reactive oxygen species (ROS) generation, changes in ROS generation and lipid peroxidation were also assessed. To find out efficacy and benefits of early starting of stimulation therapy in coma patients. Practices which limit the disposal of antimicrobial agents into the wastewater system may be the possible measure to prevent the selection of multidrug-resistant bacteria from sewage treatment plants. Genital blood flow and endometrial gene expression during the preovulatory period after Prostaglandin F(2alpha)-induced luteolysis in different luteal phases in cows. Retinal detachment after surgery of the anterior segment using the pars plana approach.

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Robert Jones National Memorial Fund Travelling Research Fellowship in Orthopaedic Surgery. The mannose-binding lectin (MBL) route for activation of complement. The LTCs were then implanted deep to a cutaneous dorsal flap in 24 allogenic recipients. The follow-up examinations ranged from 6 months to 17 years, with a mean follow-up of 6.2 years, and no tumor recurrence was noted. The switch from fetal to adult hemoglobin in humans: evidence suggesting a role for gamma-beta gene linkage. Depressive symptoms, menopausal status, and climacteric symptoms in women at midlife. Although two recent reviews by epidemiologists conclude that a clear link between tanning devices and malignant melanoma is yet to be proven, there is a strong case for effective legislation to prohibit the use of tanning devices by people under 18 yr of age. In order to clarify this problem, following experiments were performed. Because most brain metastases occur after the development of systemic disease, these findings prompt consideration of brain prophylaxis strategies with HER-2-inhibiting small molecules able to cross the blood-brain barrier and/or radiologic screening to detect asymptomatic brain metastases.

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To prevent root resorption, the retained left deciduous second molars were not aligned by the edgewise appliance. For those microspheres prepared using mixtures of CAB381-20 and cellulose acetate phthalate, scanning electron micrographs were taken before dissolution and also at different stages of dissolution (in SGF, pH 1.2 and in simulated intestinal fluid, pH 7.5). The most significant radiographic factors associated with a surgical decision were the degree of humeral head superior migration and the escape of the humeral head from the coracoacromial arch. The HLA-DR phenotype of the responder is predictive of humoral response against HLA class I antigens. We performed 5 procedures - 4 biopsies (and one vertebroplasty published earlier) on different types of lesions involving C2, through the transoral approach, using CT guidance under general anesthesia and appropriate precautions to reduce potential complications like infection, hemorrhage, etc. High-throughput cytotoxicity assays revealed glycosylation to modulate specificity and potency. However, in the prognosis of the esophageal carcinoma, hematogenous metastasis have to be taken into consideration as well as lymph node metastasis. After eight weeks of using the placebo dentifrice, subjects were examined for baseline supragingival calculus formation using the Volpe-Manhold Calculus Index. Furthermore, the attenuation of vasospasm after continuous infusion of CGS 26303 was more efficacious than that obtained with bolus injections.

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