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Alprawin (Alprazolam)

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Alprawin is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alprawin, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alprawin is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aldep, Alfresh, Alltop, Alprine, Alprocalm, Alprocontin, Alprotame, Alsert, Alzex, Alzolam, Alzomax, Anquil, Anxicalm, Anxofit, Anxyl, Aryalam, Azolam, Azoslip, Faxtin, Fultop, Hiprazole, Kurelam, Luzarn, Morecalm, Nitril, Notence, Proprazolam, Restam, Restyl, Rivcam, Serex, Sertamax, Setlan, Tenschem, Tensyn, Tranisol, Trapose, Trazopin, Trika, Xanti, Zodia, Zolar, Zolark, Zolent, Zolran, Zoltweet, Zomark, Zorest

Similar Products:
Protonix, Dulcolax, Daklinza, Celebrex, Vantin, Fulvicin, Lopid, Klonopin, Witori, Armolev, Nutoin, Flexura, Buspidac, Atova, Erythromycin, Enalind,

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprawin. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alprawin XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alprawin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of alprazolam in the pediatric population. Safety and efficacy have not been established.

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cochinchinensis was extracted with petroleum ether, and the saponification was carried out with potassium hydroxide. Furthermore, although emotional prosody and word valence may have a similar influence on an emotional judgment in both sexes, ERPs indicate sex differences in the underlying processing. Nectins have recently been identified as new cell adhesion molecules (CAMs) consisting of four members. This property is tightly connected with their ability to fuse with negatively charged natural membranes (i.e. The existence of a degradative pathway in mammalian brain for putrescine is shown, which comprises acetylation of putrescine, oxidative deamination of monoacetylputrescine to N-acetyl-gamma-aminobutyrate, transformation of N-acetyl-gamma-aminobutyrate to gamma-aminobutyrate and degradation of gamma-aminobutyrate to CO(2) via the tricarboxylic acid cycle. The advantages and shortcomings of different GFP variants are discussed along with the choice of system for leaves and possible approaches to overcoming some of the problems.

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Because cellular signaling also seems to be required for PV pathogenesis, it is important to characterize the role of direct inhibition in pemphigus acantholysis to allow establishment of new therapeutic approaches. Two metabolites, 4-hydroxyisovaleric acid and mesaconic acid, have been identified and quantified in the urine of a patient with isovaleric acidemia. A low Pb concentration in the ovary caused dysfunction of folliculogenesis, with fewer primordial follicles and an increase in atretic antral follicles. The role of brachytherapy in the 21st century for prostate cancer. NF and GFAP directed flow cytometry was able to identify several of the test chemicals as being specifically neurotoxic (chloroquine, nicotine) or astrocytoxic (atropine, chloramphenicol) via quantification of cell death in the NT2.N/A model at cytotoxic concentrations using the resazurin cytotoxicity assay.

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A 26-year-old, short statured, obese male presented with a mature teratoma located entirely within the dural confines of the sella manifesting as headaches and progressive loss of vision. We have shown earlier that the hypermethylation of the genes HLTF and HPP1/TPEF are independent prognostic serum markers in colorectal cancer identifying patients with increased risk of death. Stimulation of polypeptide synthesis by artificial nucleoproteins. This is related to the high frequency of pelvic tumours and the key role of radiotherapy in the treatment of these tumours. The data were analyzed by means of row-wise matrix correlations. Cognitive cladistics and cultural override in Hominid spatial cognition. The gene encodes an ICE1-like protein containing multiple homopeptide repeats.

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Within the pancreatic islets, beta cells produce insulin and control the glycemia. No deficiencies in neurogenesis or hippocampal BDNF and vascular endothelial growth factor secretion were found in IL-1rKO mice that were raised in a regular environment, and both of these variables were increased to a similar degree in enriched IL-1rKO and wild-type mice. The number of open discs at the base of the outer segment was used as a morphologic index to evaluate relative differences in rates of membrane assembly. This may be achieved by administering anticholinesterases such as neostigmine. Of the 12 immunized subjects, before vaccination 9 had no demonstrable rubella specific antibodies while the remaining 3 had a low level of rubella specific antibodies, reacting only with the E1 protein. Development and comparison of user acceptance of advanced comprehensive triage PDA support system with a traditional terminal alternative system. With improved understanding of the pathogenesis of chronic rhinosinusitis, it appears that much of its success lies in its ability to fully remove diseased bony partitions and to remove areas of chronic inflammation and assist in the medical management of chronic rhinosinusitis. Yields of preparasites were tripled by simply setting up three cultures, each containing 5 g of nematodes, instead of a single culture containing 15 g. This review describes different key apoptotic proteins interacting with main members of HSP family and the consequence of these events for cell survival or apoptosis. Early pharmacokinetic findings of decreased clearance with increasing dose and plasma accumulation led to the expansion of the 320mg dose level.

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A role for anion exchanger (AE)-1 in the control of nitrite export was suggested by increased intracellular nitrite concentrations in RBCs treated with DIDS. These data add to the molecular dissection of the causes of hepatocyte dedifferentiation during culture and address means to develop approaches to prevent/limit phenotype change. Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration. In our new treatment paradigm, bypass is a last resort and reserved for patients in whom balloon-test occlusion fails, who refuse parent-vessel sacrifice, and who cannot undergo primary stenting with coiling or clip wrapping. Hungary is a country which has low level of HIV infection and relatively low HCV and HBC prevalence among intravenous drug users (IDUs).

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Here we investigate the effect of morphine on herpes simplex virus-1 (HSV-1) pathogenesis using a murine flank scarification model. This paper recommends best practices to reduce negative impacts of olive production on streams, contributing to guide policy decision-makers in agricultural and water management. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Computerized physician order entry and medication errors in a pediatric critical care unit. In the absence of well-powered, randomised, direct-comparison trials, indirect comparisons are the only option for comparing treatment strategies. The dynamics of capsule formation around temporary organic glass endoprostheses has also been studied. The stimulation of the nucleus lateralis posterior (LP), nucleus ventralis posterior lateralis pars caudalis (VPLc), and nucleus pulvinaris lateralis (Pul.l) and medialis (Pul.m) induced surface-negative, depth-positive potentials in the PPC.

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The probes were derived from a galectin-3 binding 15-mer peptide sequence in which a benzophenone photolabel was incorporated at the N-terminus and in another case as a phenyl alanine replacement in the middle of the sequence. LPS-stimulated breakdown was reversibly inhibited by glucocorticoid hormones, indomethacin, and cAMP. Farnesol (FOH) production has been carried out in metabolically engineered Escherichia coli. Therefore, two different types of CAD-related advanced functional capacity impairments (post-MI and non-post-MI) can be distinguished. Based on these findings and the fact that myocilin has no known ER retention signals, the ER localization of wild-type myocilin is likely a consequence of its incomplete secretion due to its misfolding. However, the presence of ET-1 and its receptors in the mitral valve itself--promoting pulmonary vascular changes, with increased rheumatic valvular deformation--has not been discussed in the literature. In contrast to LPS, gamma-PGA induced productions of TNF-alpha and IP-10 could not be blocked by polymyxin B.

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A total of 595 households comprising 4032 people living in Gode district of Ethiopia. Although UGI is currently considered to be the imaging modality of choice in diagnosis of malrotations, numerous publications indicate that in certain patients, false positives and negatives can be encountered. It is concluded that these compounds neither directly stimulate Pi secretion in normal or parathyroidectomized birds, nor are they rate-limiting for the Pi secretory mechanism in birds infused with PTH. Furthermore, both TUNEL and pro-caspase-3 expression assay showed a significant increase in apoptosis after combined treatment with adriamycin and siRNA targeting IGF1R. However, their destruction rates increased with increasing acoustical intensity and were independent of addition of bicarbonate or chloride. The development of composite circulating biomarker models for use in anticancer drug clinical development. FITC-positive cells were characterized with anti-CD11c and anti-CD11b by three-colour flow cytometry. A case revealed prolonged cerebral vasospasm after evacuation of intracerebral hematoma. Sucrose gradient centrifugation or gel filtration in the presence of dithiothreitol and Triton X-100 separated the Mr 93,000 polypeptide from the Mr 48,000 and 58,000 polypeptides, which harbor the antagonist binding site of the glycine receptor.

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Screening termination was defined as normalization of blood pressure (BP) during the placebo screening phase. Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies. To study the effect of FSH on the aneuploidy risk of human oocytes matured in vitro. The ethics of access to oral health care: An introduction to the special issue. Reverse transcription errors undoubtedly contribute to drug resistance, but additional significant sources of viral genetic variation are debatable.

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When PTSD symptom severity scores were high, psychological aggression and the number of traumatic events children experienced rose. These findings may have important treatment implications regarding smoking cessation programs among older adults. Chemoprevention of prostate cancer is currently being tested in a wide range of clinical trials. Moreover, advanced glycation end-products (AGEs), angiotensin II (Ang II), transforming growth factor beta(1) (TGF-beta(1)), collagen IV, and monocyte/macrophage (ED-1) either in the serum or kidney were valium dosage blue significantly reduced. Computer-based clinical decision support systems (CDSSs) vary greatly in design and function.

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Interviews of caregivers of EOS patients were interpreted through the framework technique. Known quantities of the steroids 5alpha-dihydrotestosterone (DHT), testosterone, 17beta-estradiol, corticosterone, and the indoleamine melatonin were added to a stripped pool of chicken plasma. The first 20 residues of protein HMG-T2 have been sequenced and differ from protein HMG-T by only one residue. A HindIII-to-SalI fragment of 9.4 kilobases was cloned into the compatible vectors pBR322 and pACYC184. Recently, we isolated from a patient with fulminant recurrent hepatitis B after liver transplantation variants with enhanced replication competence and a possible defect in viral particle secretion. Overall, both faculty and students value the 3rd year as a unique positive experience. Among nuclear receptors, peroxisome proliferator-activated receptors (PPARs) are of special interest in relation to widespread human diseases.

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The proinflammatory cytokines IL-5, IL-4, IL-13, and TNF-alpha are among the therapeutic targets. The tricyclic scaffold reacts with amines and sodium ethoxide providing a short series of functional 9,10-dioxa-1,2-diaza-anthracene systems. Emphasis on privatization of the secondary and tertiary sectors of the system, coupled with deployment of universally-accessible, but from a clinical standpoint, limited, version of essential primary care, produces a fragmented system. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Labelled proteoglycans synthesized by the band cells were similar to those known to be synthesized by hyaline cartilage, but the attachment-region cells synthesized fibroblast-like proteoglycans. Several studies in African populations, in which more severe forms of RFGS are performed, reported an increased prevalence of posttraumatic stress disorder and other psychiatric syndromes among circumcised women than among uncircumcised controls. Conventional inhibitors for the non-specific binding of non-phosphorylated peptides can often contaminate the ion source of mass spectrometry and therefore their applications are limited in liquid chromatography-mass spectrometry (LC-MS). Our results show that many of the morphological changes of the tracheal epithelium were found in the experimental group and significant quantitative differences were observed between the two groups.

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Giant cells that developed in groups appeared the same as those which developed singly. A SWOT (strengths, weaknesses, opportunities and threats) analysis was used to review the issues facing sectoral development and identify options for future advancement of recreational fisheries to ameliorate potential conflicts with nature conservation goals. However, the role of ICOS in rat intestinal inflammation and its expression profile remains unclear. His life as a frontier physician and leading citizen of his community are documented in the context of 19th-century medicine in America and Wisconsin. We treated subjects with either imipramine or amitriptyline and compared clinical response with weekly Hamilton Depression Rating Scales, completed by raters blind to both DST results and the research question. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy protection of the esophagus from chemoradiotherapy damage during treatment of locally unresectable non-small-cell lung cancer (NSCLC). The role of I-ioflupane SPECT dopamine transporter imaging in the diagnosis and treatment of patients with dementia with Lewy bodies. From a susceptible/exposed/infectious/removed (SEIR) model with or without age-structure, the pattern of time series is dramatically modified after introducing a seasonal term. We speculate that the platelet function may be elevated in the patients.

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Unique or common protein responses to these stress conditions are summarized and interpreted according to their possible physiological responses in each stress. Mast cells (MCs) play pivotal roles in allergy and innate immunity and consist of heterogenous subclasses. Five hundred ninety seven students of five high schools in Bangkok were administered a self-reported questionnaire about acne. This has been interpreted as indicating that the transition to dependence is characterized by an protonix generic usa erosion of external stimulus control over smoking. These artefact voltages pose heavy demands on the bandwidth and dynamic range of EEG amplifiers and mean that even small fractional variations in the artefact voltages give rise to significant residual artefacts after average artefact subtraction. All patients but one were cured, and no remarkable adverse reactions were noted. Preservation of the mastoid aeration and prevention of mastoid dimpling in chronic otitis media with cholesteatoma surgery using hyaluronate-based bioresorbable membrane (Seprafilm). A systematic review of the impact of organizational partnerships on public health outcomes in England between 1997 and 2008.

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Effective and functional reconstructions is lamisil safe to use when breastfeeding with minimal morbidities are possible with the application of the standardized forearm free flap design in oropharyngeal defects. Operant conditioning and discrimination of alpha: some methodological limitations inherent in response-discrimination experiments. With the aging of our population, amiodarone, a cardiac antiarrhythmic, is being used with increasing frequency. An oblique branch of the lateral circumflex femoral artery was noted to be present in 35 percent of cases (31 of 88), and the dominant perforator supplying the anterolateral thigh was noted to originate from this branch in 14 percent of cases (12 of 88). We conclude that GluR2 receptor endocytosis and the resulting synaptic depression in ventral mPFC are crucial for cue-induced relapse to heroin-seeking. Colorectal adenomas in patients presenting with inflammatory bowel disease. Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure.

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The 45-year-old sister revealed more wide-spread degenerative changes involving not only motor neuron systems, but also proprioceptive, general somatic afferent and spinocerebellar afferent systems. It is postulated that appearance of astrogliosis may provide the neurotrophic factors to prevent or reduce neuronal cell loss in the pathogenesis of prion diseases. Antibody responses of inbred mice to red blood cells are controlled at the B cell level. Associations between socioeconomic position (SEP) and sedentary behaviour in children are unclear. Patients were divided into 2 groups according to age, namely 10 years or younger and older than 10 years. Results indicate that reticulohistiocytoma of the dorsum must be considered a primary cutaneous B cell lymphoma of follicular center cell origin.

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The ability of heparin and related glycosaminoglycans (GAGs) to accelerate the inhibition of thrombin, factor Xa and plasmin in plasma and in a purified system containing antithrombin III (At III) was studied using chromogenic peptide substrate assays. A retrograde axonal transport of nerve growth factor (NGF) from the adrenergic nerve terminals in the mouse iris to the cell bodies of postganglionic sympathetic neurones in the superior cervical ganglion has been demonstrated. Intestinal bacterial flora and tumors of the colon: intestinal excretion and degradation of neutral steroids in subjects at risk for cancer of the colon. Most of the participants with current asthma on treatment in the community would not have been eligible for these RCTs. They focus on three dependent variables: number of prenatal screenings, maternal smoking during pregnancy, birth weight of the baby. No consensus exists regarding the type of stem cell, if any, that will prove to be effective therapeutically. The risk particularly increases with recent ingestion of solid food or fluids, with older patients, with pregnant women, and with consciousness-reduced patients. The beta-expansins ExpB2 and ExpB6 showed distinctive patterns of expression and responses to low psi(w,) indicative of distinctive functions.

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In this study, we investigated the antimicrobial effect of tea polyphenols (TP) against Serratia marcescens and examined the related mechanism. Unbiased estimates of the total number of neurons and glial cells from central regions of grey matter in human brains are obtained using the disector principle in modifications which are unaffected by the histological processing of paraffin-embedded tissue. This is probably due to aggregation of the ATPase molecules and increase in the length of the borderline of lipids around each enzyme molecule. There were no significant differences in treatment requirements and quality of care between the patients. A nonlinear matched filter based image correlator is investigated. Although it is a rare medical condition, SPS is of clinical importance, especially because it may be the first sign of an underlying undiagnosed malignant disease or if the anesthesia is necessary in SPS patient.

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Four study designs were examined to assess the effect of varying incentive and KW experience in classification accuracy. Online gaming dependency was also positively related to different types of negative life outcomes. chabaudi, Plasmodium berghei and Plasmodium yoelii lysates but does not recognize the recombinant CP-2 extracts suggesting high antibody specificity. The excellent results obtained on STED microscopy images demonstrate the synergy between super-resolution techniques and image-deconvolution. The association between colorectal cancers and alcohol consumption, when it is found, apparently occurs at even relatively does alcohol affect the effectiveness of bactrim low alcohol intakes and is often stronger for consumption of beer than of other beverages. Rats undergoing either sham operation or ligation of the extrahepatic bile duct (BDL) for 2 weeks were randomly assigned to receive intravenous injections of dexamethasone (DX) or normal saline (NS) prior to infusing LPS into the biliary tract. Morphine-induced desensitization was attenuated by using RACK inhibitors that inhibit PKCalpha, but not by other isoform-specific inhibitors. Relationships between specialized cells, capillaries and intermediary cytofibrillary elements. This review highlights the key messages from the KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guidelines for care of kidney transplant recipients, which were written to be global guidelines irrespective of the regulatory, fiscal, cultural, socioeconomic, or geographical environment. At the end point of an optically clear well, the minimum inhibitory concentrations (MICs) ranged from 0.5 to 8 microg/ml for sophoraflavanone G, from 64 to 1024 microg/ml for ampicillin, and from 256 to 1024 microg/ml for oxacillin.

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