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Alprazolam is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). Alprazolam is mostly used to treat anxiety disorders, panic disorders, and nausea due to chemotherapy. Alprazolam may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. The FDA label advises that the physician should periodically reassess the usefulness of the drug.

Other names for this medication:
Actirax, Alflux, Alprazan, Alprine, Alpron, Alprotame, Alzin, Alzoft, Alzom, Alzopax, Alzot, Anquil, Anxicalm, Anxizam, Anxofit, Azicalm, Azolam, Benzax, Cozac, Elflu, Fluwel, Fluxozam, Fultop, Hipose, Manzolam, Mediprex, Meloprax, Morecalm, Pacyl, Parazolam, Paxor, Pralam, Procalm, Prozam, Prozolam, Restyl, Rozin, Sanprazole, Setex, Sinzolam, Tenil, Tenolam, Unixl, Welnorm, Zolam, Zolran

Similar Products:
Bystolic, Urispas, Uroxatral, Claritin, Tofranil, Floxin, Duphaston, Pepcid, Arimidex, Elflu, Alergin, Nacet, Ritosin, Alvin, Floramin,


Alprazolam XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

Alprazolam XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Alprazolam XR may also be used for other purposes not listed in this medication guide.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprazolam. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprazolam dosage information

Side effects

The most common side effects associated with Alprazolam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Alprazolam if you are pregnant. It could harm the unborn baby.

Do not use this medication if you are allergic to Alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before you take Alprazolam, tell your doctor if you have asthma or other breathing problems, glaucoma, kidney or liver disease, a history of alcoholism, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Do not drink alcohol while taking Alprazolam. This medication can increase the effects of alcohol.

Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

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Cranial radiotherapy-induced growth hormone deficiency, other direct adverse effects of radiotherapy and anthracycline-induced left ventricular dysfunction are clearly identified risk factors for developing these complications. The effects of the flow pattern on organic oxidation and nitrification in aerated submerged biofilters. The use of rat urine extracted on XAD-2 resin and assayed in a microsuspension-modified Ames test as an in vivo indicator of genotoxic exposure. The authors report two cases of fulminant hepatitis in children. However, after multivariate analysis only antinuclear antibody positivity at the end of treatment and increase of smooth-muscle antibody titres were associated with worst treatment response, independently of known factors of worst treatment outcome. Microtubule density was used as a measure of the extent of axonal degeneration and was assessed by a computer-aided analysis of electron micrographs.

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Longitudinal split anterior tibial muscle flap with preserved function. The molecular map will be used to identify DNA corresponding to Mi. Problems of early diagnosis of space-occupying intraspinal lesions are discussed in relation to 335 patients on whom surgery had been carried out. The dilemma of atrial fibrillation in intracerebral haemorrhage: how to balance the risks of ischaemia and bleeding. First, we discuss the regulation of circadian gene expression as assayed with microarrays. Measles elimination: lack of progress in the Western Pacific Region. Chiral analysis of UV nonabsorbing compounds by capillary electrophoresis using macrocyclic antibiotics: 1.

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Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus. The current study describes a model of bladder instability induced in female rabbits and its use in developing a novel form of vaginal treatment for this instability. Resveratrol, a natural polyphenolic compound, was shown to protect rodents against high-fat-diet induced diabesity by boosting energy metabolism. The study revealed three well demarcated areas: the human settlement area, the agricultural area and the primary tropical rain forest. Diamond stents for palliation of malignant bile duct obstruction: a prospective multicenter evaluation. Personal digital assistants (PDAs) offer opportunities to speed the process of data collection and analysis. Recent large-scale genome-wide association studies have identified a novel susceptibility locus on chromosome 9p21.3 that contributes a significant attributable risk for myocardial infarction.

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Apheresis, a therapeutic procedure that has been available for decades, has recently been added to the long-term management of rheumatoid arthritis (RA). Emergency department crowding: emergency physicians and cardiac risk stratification as part of the solution. Twenty-six key informants were interviewed, and responses were analyzed to identify major themes. Dominant negative PKB reduced PKB activity and insulin-stimulated glucose transport but not HRG-induced glucose transport. The initial sorption rate, pseudo-first-order, pseudo-second-order and intraparticle diffusion rate constants for different initial concentrations were evaluated and discussed. We assessed age, gender, presenting symptoms, localization, pathologic diagnosis, type of procedures, complications, and survival. Taken together, our results suggest that p53, p16, p21 and Rb are not reliable biomarkers for prognosis of the tumor severity or recurrence in squamous cell carcinoma of the oropharynx as depicted by tissue microarrays and immunohistochemistry. Primary cardiac echinococcosis: report of two cases with review of the literature. The following 3 themes emerged from the analysis as risk factors for initiating smoking by adolescents: personal factors, social factors and beliefs about smoking. Final grades were assigned through faculty judgment rather than by the use of a numerical formula.

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A alpha-glycerophosphate dehydrogenase is present in Trypanosoma cruzi glycosomes. Poor interpretation of written information on medicines has been shown to lead to anxiety and poor compliance to therapy. The mean serum lithium half-life in 8 patients with therapeutic intoxication was considerably longer than in 5 self-poisoned patients. Spore formation was not affected by amplification, so spoIIA-lacZ reiteration did not sequester a molecule required elsewhere for sporulation. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis: 2001 edition, with selected updates for 2003. incognita in the breeding line followed the same pattern as with K399, but in lower numbers. To search for new compounds with strong anti-inflammatory activity and low gastrointestinal (GI) side effects. Subluxation/luxation of the second carpal bone in two racing greyhounds and a Staffordshire bull terrier. We have investigated whether inositol 1,4,5-trisphosphate (InsP3) functions as such an internal transmitter, given that InsP3 may act as an intracellular messenger in other cellular processes.

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Here we investigated the effects of low-frequency EA and physical exercise on mRNA expression of sympathetic markers in adipose tissue and on ovarian morphology in female rats that received dihydrotestosterone (DHT) continuously, starting before puberty, to induce PCOS. The finding that IRT scoring diminished the impact of DIF is discussed. A biotin-avidin amplified enzyme immunoassay for detection and quantitation of orthopox virus camel antibodies in dromedaries. The idea of a functional role for cAMP-dependent protein kinase subunits in cAMP-mediated gene control has already had experimental support, but our identification of the regulatory subunit RII as a topoisomerase now more firmly points to a complex function for the kinase in regulating gene function at the DNA level. In hormone-treated etiolated seedlings, VR-ACS7 was primarily induced in the rapidly elongating zones of hypocotyl and epicotyl tissues, while auxin-induced VR-ACS6 mRNA was evenly distributed throughout the whole seedling. Fifty healthy Wistar rats were randomly divided into a normal control, a long-term heavy smoking group, a long-term light smoking, a short-term heavy smoking and a smoking cessation group. Patients were followed up postoperatively at 3-month intervals with renal function studies and enhanced imaging. Enzymes were assigned to 16 different metabolic pathways related to both primary and secondary metabolisms. The Assessment of Digital Study Models Using the GOSLON Yardstick Index. In this study, genomic and sequence-based approaches were integrated to reconstruct the phylogeny of P.

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Its correlation with both HPV status and degree of LOH as a surrogate for genomic instability may reflect alternative oncogenic pathways in HPV-positive versus HPV-negative tumors. The mean basal discharge rate and degree of burst firing was also different between these subgroups of midbrain dopaminergic neurons. Indeed, the reported frequencies of MSI differ widely in each malignancy. Effect of proteolytic enzymes on the functional activity of the neuron. Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetes. The relationship between blood HbA1c levels and surgical treatment outcomes of 21 diabetic patients undergoing open reduction internal fixation (ORIF) for ankle fractures was analyzed with Pearson correlation testing and t testing. Possible concern over the risks of anesthetic in the elderly may be one of the foremost concerns. Pyramidal cell fields were unaffected in the LRP6, Lef1, or double mutants. The corresponding double endonuclease and PCR analysis certified the successful cloning of the gene into the pShuttle-CMV.

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The fragment that reconstituted most effectively also formed nucleosomes that were unusually stable to heparin challenge. Between February 2001 and August 2004 a total of 57 penile prostheses were implanted by 10 surgeons at a large urology practice (multiple surgeon group). Localization of parathyroid adenomas by sonography and technetium tc 99m sestamibi single-photon emission computed tomography before minimally invasive parathyroidectomy: are both studies really needed?. Phencyclidine increased directly elicited twitch tension while it decreased post-tetanic potentiation of the indirectly elicited twitch tension. Influence of resistance exercise on lean body mass in aging adults: a meta-analysis. Incorporation of a second disulfide bond results in significant overall rigidity, and in one case, a structure close to that of V3(MN) peptide bound to 447-52D Fab was assumed and in another case a structure close to that formed by the linear V3(IIIB) peptide bound to antibody 0.5beta was assumed. Prior to each study visit, subjects refrained from brushing their teeth and eating and drinking for four hours. Suppression of unitary activity in the prepiriform cortex by activation of the olfactory bulbs. In conclusion, inhibition of early endogenous nitric oxide formation is an efficient procedure for obtaining hepatocyte cultures with stable expression of differentiated functions, high cell survival and few signs of cell senescence. Thus, our results suggest that the evolution of traits relating to stoichiometry can affect the dynamics of the systems, and the outcomes the dynamics change greatly depend on which traits can evolve.

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Biomolecular interaction analysis in drug discovery using surface plasmon resonance technology. All participants were monitored for signs of systemic and local intolerance. It has been hypothesized that the molecular mechanism that measures the life span of a cell probably involves the shortening of telomeres that occurs with each round of DNA replication. A 1-day cross-sectional survey was completed in all medical and surgical wards and some specialist outpatient clinics. Small FOV MRI provided more detailed morphological information of talar OCL.

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A new method based on dynamic programming for boundary detection in ultrasound image sequences. Immunohistochemical staining of FBJ virus-infected cells revealed intense, nuclear staining. The method has been successfully tested on in vitro and clinical cases. C1 INH did not primarily act via inhibition of the complement system, but via the kinin and coagulation cascade. Earlier molecular phylogenetic analyses based on nuclear small subunit ribosomal DNA (nSSU rDNA) suggest that the Zygomycota are polyphyletic within the Chytridiomycota. Neural stem cell (NSCs) are self-renewing, multipotent cells able to generate neurons, astrocytes and oligodendrocytes. Analysis of extractable peptides showed that sub partu collagen was degraded in preference to noncollagenous proteins into very small fragments, whereas in the process of prostaglandin-induced cervical ripening collagen degradation appears to be of minor importance. A single amino acid residue is responsible for species-specific incompatibility between CCT and alpha-actin.

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The activation of both Erk1/2 and ETS1 is increased in the CIA synovial fibroblasts. Endovascular treatment of intrahepatic inferior vena cava obstruction from malignant hepatocellular tumor thrombus utilizing Luminexx self-expanding nitinol stents. Quality of life assessment in advanced non-small-cell lung cancer patients undergoing an accelerated radiotherapy regimen: report of ECOG study 4593. We still do not have statistics regarding the participation of the media in disseminating Bioethics in Brazil, but, as the leader cozaar 50 mg picture of an institution that pioneered educational programmes and initiatives linked to Bioethics that reach our whole country, one may say that we can point out that the Internet, in addition to being a communication medium, that is to say, communication by means of electronic mails, is the main media as regards access to and broadcasting of literary (philosophical and scientific) production in Bioethics today. Rehabilitation of leprosy-affected persons extends beyond the physical domain of prevention and treatment of impairments.

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The partition coefficients from water to membranes of different compositions, as well as the corresponding thermodynamic parameters, indicated that membrane partitioning was an entropically driven process. Quantitative determination of aggregated IgG in gamma globulin preparations. Supporting the aforementioned hypothesis the effect of institutional trust in the government was significantly more negative on anxiety during the crisis than its aftermath. The principal glycolipid targets are found in the ganglio and lacto series tenormin tab 100mg of glycosphingolipids, and not in the globo series. Confocal microscopy showed that these peptides penetrated the cell membrane of Escherichia coli and accumulated in the cytoplasm, as observed for buforin-2. Seed bacterization showed significant plant growth promotion and Fusarium-wilt suppression activity of Phaseolus mungo in a gnotobiotic system. It thus appears that there is an increased number of presynaptic dopamine releasing nerve terminals in the basal ganglia, possibly as a biological adaptation to counteract the postsynaptic dopamine D(2)-receptor blockade.

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Serum gamma-glutamyl transpeptidase isoenzyme in congenital biliary atresia. Signalling via p38 leads to increased phosphorylation and activation of cyclic adenosine monophosphate response element-binding (CREB) that binds and activates the Mitf promoter via the cyclic adenosine monophosphate (cAMP) response element. This is problematic because vitamin D deficiency can present as musculoskeletal pain, which is commonly seen in both outpatient clinics and inpatient rehabilitation units. To obtain a better understanding of the factors involved in resistance, nitroreductase and metronidazole reduction activities were investigated in matched pairs of clinical and laboratory-derived sensitive and resistant H. Providers should consider needle biopsy when clinically feasible as the initial breast procedure, because it may reduce tricor tabs 145 mg the number of surgeries needed to treat breast cancer. Simultaneous recordings from glass microelectrode and NWFET devices show that NWFET conductance variations are synchronized with the beating heart.

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In the dose assessment model, the objects with surface contamination are classified into three types: manually handled, closely handled and remotely handled objects, and the exemption criteria are chosen to be 0.01mSv/yr in the case of using realistic exposure parameters and 1mSv/yr in the case of using low-probability exposure parameters in accordance with the IAEA Safety Standards Series No. Insights into the formation and isomerization of the benzene metabolite muconaldehyde and related molecules: comparison of computational and experimental studies of simple, benzo-annelated, and bridged 2,3-epoxyoxepins. In contrast to secondary prevention, the extent of the target population and the utilization of lipid-lowering drugs are insufficiently clear. The authors hypothesized that genistein, through the inhibition of NF-kappaB, could enhance the activity of EGFR-TKIs in NSCLCs. This article reports the development and psychometric properties of a new scale that measures internalized homophobia in lesbians: the Lesbian Internalized Homophobia Scale (LIHS). Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Renal deposits of lipoprotein-immunoglobulin complexes in Plasmodium chabaudi-infected mice. Quantitative (124)I PET imaging is challenging as (124)I has a complex decay scheme.

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The decisive factors for the outcome of lower gastrointestinal hemorrhage requiring surgery are the severity of bleeding, beginning of treatment (initial hemoglobin level, need for packed red blood cells), and treatment efficiency (necessary reoperation). Frozen cerebellar samples were obtained from postmortem brains of 10 subjects free from neurological and psychiatric disease. MicroRNAs (miRNAs) are a class of small noncoding RNA genes found to be abnormally expressed in several types of cancer, suggesting a role in the pathogenesis of human cancer. Hyperglycaemia, fever, and swallowing dysfunction are poorly managed in the admission phase of acute stroke, and patient outcomes are compromised. To construct antisense c-Jun N-terminal kinase 1 (JNK1) eukaryotic fluorescent expressing vector and JNK1-/- human embryo lung fibroblasts cell line. Here, we report that flounder and two fugu species, Takifugu and Tetraodon, have a single lefty gene in their genomes. We introduce a new in vitro display system, bead surface display (BeSD), in which a gene is mounted on a bead via strong non-covalent (streptavidin/biotin) interactions and the corresponding protein is displayed via a covalent thioether bond on the DNA. Brain magnetic resonance imaging (MRI) confirmed an infarct in the left middle cerebral artery area. No frank deficiencies in hormone production were seen with the elavil ACTH, GH-releasing factor, and TRH responses in CH dogs relative to those in normal dogs. Pregnancy and the post-partum period profoundly influence MBL serum concentration and MBL complement pathway activity.

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A cross-sectional study was performed in a cohort of 106 patients (54 men and 52 women) with functioning renal allografts, who underwent bone densitometry (DEXA) of the lumbar spine and femoral neck. The role of other micronutrient deficiencies or goitrogens should be investigated. Receptor-receptor interactions within receptor heterodimer/receptor mosaics of different receptors in the ventral striatum and cerebral cortex give novel strategies for treatment of schizophrenia involving, e.g., monotherapy with either A(2A), mGluR5, CB(1) or NTS(1) agonists or combined therapies with some of these agonists combined with D(2)-like antagonists that specifically target the ventral striatum. Normothermic Pm of 30 min duration results in immediate and delayed gut barrier failure by significantly increasing BT and endotoxaemia which might be attributed to portal stasis leading to intestinal congestion as well as temporary liver ischaemia. Low serum levels of beta-carotene have been associated with increased risk of cancer and cardiovascular disease. The information obtained may lead to new directions in the area of drug discovery, as recent research has demonstrated the continued promise of looking to natural products for bioactive compounds. With respect is norethindrone acetate a mini pill to the effects of HRT, oral estrogen is associated with elevation in C-reactive protein and varied effects on IL-6, but transdermal estradiol has no significant effect on these parameters. Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.

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Data were collected over a 12-month period from children under 6 years of age with a provisional diagnosis of UTI made in the Emergency Department of Sunshine Hospital, Victoria. Pentane in exhaled gas is often used as an index of lipoperoxidation, but today, there is no standardization for its measurement. Neighborhood security and solidarity among neighbors are important for the well-being of community-dwelling older people. Endogenous galectins and the control of the host inflammatory response. We report an 8-year follow-up of a girl who developed multiple episodes of central nervous system demyelination at the age of 3 years consistent with multiphasic acute disseminated encephalomyelitis. Incidence and risk factors of retinopathy of prematurity in mashhad, northeast iran.

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