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Alprogard (Alprazolam)

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Alprogard is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alprogard, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alprogard is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Almac, Alpradol, Alprazan, Alzocum, Anxico, Anxitab, Anxorel, Cardilax, Ecsit, Exiten, Fludep, Golprax, Maxorest, Nexlpra, Prazil, Prosanti, Resta, Resto, Samrox, Sowel, Tancalm, Tenfree, Tensyl, Texidep, Tranisol, Zeftra, Zepro, Zolark, Zolipax, Zolran

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Micardis, Vermox, Urispas, Minipress, Nuvigil, Tenormin, Imovane, Progene, Tackodom, Lorday, Auxxil, Dezacor, Meneklin, Clindacyl, Etofree,

Also known as: Alprazolam


Alprogard XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

Alprogard XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Alprogard XR may also be used for other purposes not listed in this medication guide.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprogard XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alprogard XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprogard XR dosage information

Side effects

The most common side effects associated with Alprogard are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of alprazolam in the pediatric population. Safety and efficacy have not been established.

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All isolates were facultatively anaerobic, long Gram-positive, straight rods resembling Clostridium sp. melanogaster resides in two resources: its powerful genetic tools as a model system, and a natural ecology that provides substantial genetic variation across significant environmental heterogeneity. Systemic disease can now be treated by enzyme replacement therapy (ERT), but its efficacy in NGD is limited. UM-UC-1 and UM-UC-2: characterization of two new human transitional cell carcinoma lines. Mature virus particles were likewise observed in a stable cell line FLK (percent of the virus) as well as in ultrathin cross sections of the spleen of leukosis-affected animals. Treatment of wastewater on a large scale will also be possible by using reactors containing immobilized enzymes. In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. This paper deals with the synthesis of a biocompatible chitosan ammonium salt N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) and using it in montmorillonite ion-exchange process. A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity. Furthermore, many IgG MoAbs reactive with NSCLC lines are poorly reactive with SCLC cells.

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In the contemporary management of posthysterectomy bleeding, the pelvic pressure pack appears to be a valuable surgical option, affording correction of coagulopathy and further stabilization. In other words, the response may be affected by levels of predictors in spatio-temporal proximity to the response location. Nucleic acid testing (NAT) in routine HIV testing programs can increase the detection of infected individuals, but the most effective implementation of NAT remains unclear. This study indicates that allergic rhinitis is associated with an inadequate level of asthma control, giving support to the recommendation of evaluating rhinitis to improve asthma control in children. Although this constitutes the reason for our failed attempts to prepare poly(m-phenylene-alt-squaraine)s, the discovered influence of hydrogen bonding on the photophysical properties of these semisquaraines provides a promising new motif for sensor design. The results are comparable with published data on silicone implant arthroplasties. Use of microplate cell culture and enzyme immunoassay in titration of serum neutralizing antibody against Hochi strain of serotype 4 human rotavirus. Notably, a single administration of these compounds brought about profound analgesic tolerance that lasted for more than 14 days. Fatal hepatitis B reactivation due to everolimus in metastatic breast cancer: case report and review of literature.

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In patients with different types of calciuria the 2 main risk factors (hyperoxaluria and hypercalciuria) for the process of stone formation are recognizable more readily in the postprandial urine specimens than in fasting or daily urine specimens. Among five subdomains of the general NPE measured by the Practice Environment Scale of the Nursing Work Index, Nurse Participation in Hospital Affairs was positively related to quality of geriatric care, whereas two subdomains were not significant, and another two were negatively related to quality of geriatric care. The chemical nature of fetid floral odours in stapeliads (Apocynaceae-Asclepiadoideae-Ceropegieae). Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model. Cells adhering to laminin-8 displayed streaks of thin actin filaments and formed lamellipodia at the leading edge of the cells, as observed with cells adhering to laminin-10/11, while cells on fibronectin showed thick actin stress fibers and large focal adhesions. Our results suggest that hexyl and octyl substituted pyridinium-based ILs can be fully mineralized, but that imidazolium-based ILs are only partially mineralized. This review is focused on a subset of cranial motor neurons called the branchiomotor neurons, which innervate muscles derived from the branchial (pharyngeal) arches. A preceptorship is one of the effective factor in clinical education. The ratio of Bax/Bcl-2 was raised by plumbagin in a concentration-dependent manner.

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Inner ear deafness and isolated stenosis of the internal auditory canal. The role of the opsonophagocytic system in the pathogenesis of sepsis. Based on the analysis of conserved regions of the cry1A genes, the 1AF and 1UR oligonucleotide primers were designed to amplify the whole open reading frame of these genes. Purple urine bag syndrome in nursing homes: ten elderly case reports and a literature review. Reconstruction of chest wall defects is performed by a variety of surgical procedures. Due to antithrombotic therapy before, during, and after percutaneous coronary intervention (PCI), and due sometimes to the need for an urgent reintervention, the arterial femoral sheath is generally not removed immediately after PCI, unless a vascular closing device is used. We double-immunolabelled developing mouse palates with anti-TGF-beta(1) or anti-TGF-beta(3) antibodies and TUNEL, added rhTGF-beta(1) or rhTGF-beta(3) or blocked the TGF-beta(1) and TGF-beta(3) action at different concentrations to WT or Tgf-beta(3) null mutant palate cultures, performed in situ hybridizations with Tgf-beta(1) or Tgf-beta(3) riboprobes, and measured the presence of TUNEL-positive midline epithelial seam (MES) cells and MES disappearance (palatal shelf fusion) in the different in vitro conditions. Conduct a study of sixth year students of one medical school is likely to result in restrictions on the relevance of external applications and the ability to generalize the entire population of medical students in Poland.

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For the South African context, the community/hospital indicators are a measure of the extent of resource redistribution from hospital to community services and changing patterns of service utilisation over time. By phenol-water extraction an aqueous-phase soluble cellular lipopolysaccharide was isolated from Haemophilus pleuro-pneumoniae serotype 1. Duration of breast feeding and bovine serum albumin antibody levels in type 1 diabetes: a case-control study. Histological examination of the arterial system originating from the aortic adventitia in experimental atherosclerosis. The isolation from spleen tissue of high molecular weight proteins which alter vascular permeability: investigation of their pharmacological properties. Development of competitive PCR for detection of Butyrivibrio fibrisolvens in the rumen. Suicidal ideation of psychiatrically hospitalized adolescents has one-year predictive validity for suicide attempts in girls only. Basing lifetime cost estimates on short-term data overestimated the costs for ICH and underestimated those for IS. Reflex effects from the afferent fibers of the vagus nerve on the blood flow in the skeletal muscle and coronary vessels and cardiac contactility.

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Long-term effectiveness of a quality improvement program for patients with type 2 diabetes in general practice. The specificity and selectively of the targets of the new biologic agents render them less toxic than the oral maintenance drugs and thus could possibly replace those drugs most frequently associated with long-term toxicity such as the corticosteroids and the calcineurin inhibitors. Thus, administration of EtOH might increase the risk for compulsive use of MDMA, an issue that warrants further study. It is widely acknowledged that health information on the Internet is of variable quality and therefore the search and appraisal skills of consumers are important for selecting and assessing this information. Putative quantitative trait loci associated with the probability of contracting infectious bovine keratoconjunctivitis. Primary: incidence of human preembryos with chromosomal abnormalities.

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Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain. Acetaldehyde increased the phosphorylation of beta-catenin on Tyr-331, Tyr-333, Tyr-654 and Tyr-670. Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection. Recognition of human polymorphonuclear leukocyte receptors for leukotriene B4 by rabbit anti-idiotypic antibodies to a mouse monoclonal antileukotriene B4. The effects of the larger doses of 7-NI (150 and 200 mg/kg) were effectively prevented by the increase of NO and not the ineffective dose of L-arginine. Gastric lipomas were characterized from the clinical viewpoint by dyspeptic disturbances that were not systematized, as well as by bleeding while the ileal and the colic tumours were accompanied by repeated invagination. This step-growth process can be controlled to prepare dimers, oligomers, and polymer-like gold nanoparticle chains by varying the ratio of alkanedithiols to nanoparticles.

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Contrary to what was expected, sage tea drinking significantly increased the CCl(4)-induced liver injury, as seen by increased plasma transaminase levels and histology liver damage. Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart. The role of mast cells in atopy: what can we learn from canine models?. A secondary objective was to determine if premedication with pregabalin would reduce postoperative pain. Moreover, different patterns of apoptotic markers were found, namely a PCD process independent of ROS accumulation in V.

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In this retrospective study we evaluated the clinical features and molecular bases of hearing loss associated with multi-systemic mitochondrial cytopathy. Epidemiological studies on the effect of urban air pollution on childhood asthma have shown conflicting results and so far no consistent association has emerged. Three-dimensional videographic and electromyographic data were collected for 36 recreational athletes (17 men and 19 women) performing vertical stop-jump tasks. The anti-inflammatory action of this sulfated polygalactose does not depend on its anti-coagulant activity. Effect of superoxide dismutase on hydroxylase activity and hydrogen peroxide formation in anthranilamide hydroxylation by a rat liver microsomal monooxygenase system. The present study shows that active blastocyst hatching occurs in vivo because both hatching blastocysts and empty ZP can be found within the uterine cornua of ICR mice before implantation. Cases were assessed over an 18-month period, identifying on-scene time, incidence of rapid sequence induction (RSI), management of patients with a Glasgow motrin dosage per day Coma Scale (GCS) score of 3, femoral fracture, pneumothorax or those with myocardial infarction.

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Cigarette consumption, expressed as either pack-years or cigarettes smoked per day, showed a similar inverse relationship with the rhinometric measures even though a linear dose-response relationship could not be established. It presents a 59 years old woman with atypical symptoms, which orientated the diagnostic thinking during one year to a reccurrent pneumonitis, bronchial asthma, colagenosis, interstitial pulmonary fibrosis and so on. Impaired learning and memory performance is often found in aging as an early sign of dementia. An improved understanding of this concept may help to transfer knowledge between different areas of chemistry and nanoscience. Egr1 also plays important roles in many aspects of vertebrate development. Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition. Nonselective enrichment for yeast adenine mutants by flow cytometry. Among these activities, the presence of a group of high molecular weight (HMW) MMPs independently serves as a multivariate predictor of the metastatic phenotype (). Elevated levels of CRP in cancer-free individuals are associated with increased risk of cancer of any type, of lung cancer, and possibly of colorectal cancer.

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Significance of inducible very fast ventricular tachycardia (cycle length 200-230 ms) after early reperfusion for ST-segment-elevation myocardial infarction. Mid-dermal injection of stabilized hyaluronic acid (HA) is well established as a treatment to reduce the effects of skin aging. Five fecal samples were collected during the trial, and total bacteria and several main groups of bacteria in colon were analyzed by fluorescence in situ hybridization (FISH). The uptake of (99m)Tc-HMPAO was 15--25-fold higher in eosinophils than in other leucocytes. Circular proteins are grouped into distinct classes according to their origin and sequence similarities.

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A generalized impairment in calcium handling in vascular smooth muscle,including the calcium influx through the voltage-operated and receptor-operated channels and calcium release from intracellular calcium stores, is involved in vascular hyporeactivity during the late phase of sepsis. As the proteasome plays a crucial role in the control of the inflammatory process and immune cell survival, targeting the proteasome appears as a novel approach for the prevention and treatment of inflammatory autoimmune diseases. Consequently, the proposed solution is of great interest and appears to be very promising, not only because of the numerous potential applications of XRD in materials science, but also the possible expansion of the solution to several other characterization techniques. Echocardiography during both provocative tests showed that the interatrial septum flattened or became convex toward the left atrium. At a mean follow-up of 42 months (range, 12 to 64 months), the mean preoperative Knee Society and function scores had improved from 24 and 34 to 94 and 85, respectively, at follow-up. We plan a cohort study in the general population aged 50 years and over to determine the course and prognosis of hand, hip, knee and foot pain, and the impact of these syndromes on participation levels and health care use. Genes in the deleted region possibly related to the clinical symptoms of our patient include NOTCH3 (MIM600276), causative of the vascular neurodegenerative disorder CADASIL and CASP14 (MIM605848), playing a central role in apoptosis in the inner root sheeth of the hair follicle. A microbiological etiology can be established in practically all cases. By blocking NMDA can i take zyrtec with cold medicine excitation or GABA inhibition, an excess of zinc may alter the excitability of hippocampal circuits, which contribute to the development of seizures. Hidden rheumatoid factor in latex negative test sera of patients with rheumatoid arthritis.

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Then, the changes of body weight, spleen index of mice, the inhibition rates of tumor, and the increase of life span (ILS) were all tested. Proteasome inhibitors had a similar effect to cadmium on the cellular accumulation of ATF5. Pit formation by a wavelength-tunable free electron laser (FEL) irradiation on the gypsum pellet maximized at a wavelength of 3.0 microm, 2 mJ/shot, and pits were not detected in those irradiated at 2.6 or 3.8 microm compared with the maximum at 3.0 microm and diminished at 2.0 or 4.0 microm in the human tooth case. Pneumonia hospitalizations were substantial, especially for the youngest and oldest age groups. It clicks when it is rolled and it squeaks when it is squeezed: what 10-month-old infants learn about object function. 1,2-Bis(N-fluoro-p-toluenesulfonamido)ethane chloroform solvate. Left main coronary artery embolus: unusual presentation mometasone formoterol generic of papillary fibroelastoma of the aortic valve.

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