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Alprostadil

Alprostadil is a medicine that men take for ED (erectile dysfunction). It’s only available by prescription. This drug makes the blood vessels expand. That boosts blood flow throughout the body, including the penis, so it helps men with ED have an erection.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Description

Alprostadil, like its contemporaries Edex, Muse and Caverjet, is an impotence agent and vasodilator known as prostaglandin E1. Alprostadil is usually used by men when the blood vessels, nerves and muscles in the penis do not work properly. This unique medication treats every type of erectile dysfunction - vasculogenic, psychogenic, mixed and neurogenic etiology. The prostaglandin E1 relaxes the blood vessels and thins the blood, delivering blood flow to the penile area and causing a hard erection. The main advantage of Alprostadil is its quick action, just 5-10 minutes after injection. The effects last for 30-60 minutes but may vary slightly from patient to patient. Alprostadil doesn't protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.

Dosage

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the treatment of erectile dysfunction:
    • For injection dosage form:
      • Adults—1.25 to 60 micrograms (mcg) as a single dose once a day. Your exact dose will be determined by your doctor. Inject this medicine very slowly into your penis as shown to you by your doctor 10 to 30 minutes before intercourse. Allow 5 to 10 seconds to completely inject the dose. Do not inject more than one dose within 24 hours. Also, do not use this medicine for more than 2 days in a row or more than 3 times a week.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Storage

Store unopened foil pouches in the refrigerator at 36-46 degrees F (2-8 degrees C). If necessary, this product may also be stored at room temperature below 86 degrees F (30 degrees C) for up to 14 days. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Side effects

The most common side effects associated with Alprostadil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Alprostadil if you are allergic to any of its components or to other prostaglandins. Do not take Alprostadil if you have blood problems such as sickle cell anemia or sickle cell trait, leukemia. You should not be treated with Alprostadil injection if you have penile implants. Do not take Alprostadil if you have penile problems, e.g. a curved or deformed penis. Do not use Alprostadil if you have multiple myeloma or other bone marrow problems. Do not take Alprostadil if you take other medicines for the treatment of erectile problems. Consult your doctor or health care professional immediately if the erection lasts longer than 4 hours or if it becomes painful. Alprostadil is not a protector from sexually transmitted diseases or pregnancy. Avoid having unprotected sex. Do not share drug needles. Do not drive or operate machinery while taking the medication. Avoid consuming alcohol as it may worsen the medication side effects. Alprostadil does not protect you and your partner from sexually transmitted diseases and pregnancy. Alprostadil is not for use in women, children or newborns.

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Separation and prolongation of viability of human lymphocytes for tissue typing. Sex, Obesity, and Blood Pressure Among African American Adolescents: The Jackson Heart KIDS Pilot Study. Intermittent hemodialysis has been the treatment of choice when emergent extracorporeal lithium clearance is indicated, but postdialysis rebound elevations in lithium concentration with recurrent toxicity have been documented. Older patients with lung cancer present with multiple deficiencies covering all geriatric domains. We report on the endoscopic creation of a fetal urethrotomy for obstructive uropathy resulting from anterior urethral valves. Mental spatial transformation of imitable body posture relies on emulation processes, a mechanism through starlix diabetes medicine which the posture is covertly imitated by the observer.

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The metabolic effect of trans isomers are today a matter of controversy generating diverse extreme positions in light of biochemical, nutritional, and epidemiological studies. Prevalence and risk factors of diarrhea morbidity among under-five children in India: A systematic review and meta-analysis. Long-term efficacy of azathioprine treatment for proliferative lupus nephritis. Drivers answered a structured interview, were breathalyzed, and had their saliva collected for drug screening. We may conclude that putative small stem cells expressing markers, related to pluripotency, are present in the ovarian tissue sections of women with borderline ovarian cancer and high-grade serous ovarian carcinoma thus indicating their potential involvement in ovarian cancer. Each biopsy specimen was reviewed by two pathologists who were blinded as to the clinical data. For more than five years, patients referred to the Department of Otolaryngology-Head and Neck Surgery at the University of Texas Southwestern Medical Center at Dallas with allergic fungal sinusitis (AFS) have been managed using a regimen combining surgery, perioperative corticosteroids, and immunotherapy for relevant antigens (fungal and non-fungal). Histological processing of the surgical specimens showed two spherical ischemic necroses surrounded by a connective tissue border with inflammatory infiltration. Kinetics of Photocontrollable Micelles: Light-Induced Self-Assembly and Disassembly of Azobenzene-Based Surfactants Revealed by TR-SAXS. One hundred forty-five subjects, including naturally postmenopausal women aged 40-60 (who had not experienced menses for at least 12 months), women who had undergone hysterectomy, and women aged 25-60 who had undergone bilateral oophorectomy with or without hysterectomy were studied.

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