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Amantral

Amantral is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to widespread drug resistance.

Other names for this medication:
Amantadine, Amantral, Amantrel, Comantrel, Neaman

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Also known as: Amantadine

Description

Amantadine is an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. Amantadine is also used to treat stiffness and shakiness caused by certain medicines that are used to treat nervous, mental, and emotional conditions.

Amantadine is also an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A). It may be given alone or together with flu shots. Amantadine will not work for colds, other types of flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain amantadine. It may not be specific to Amantral. Please read with care.

For patients taking amantadine for Parkinson's disease or movement problems (including dyskinesia) caused by certain medicines used to treat nervous, mental, and emotional conditions:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide or patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. Improvement in the symptoms of Parkinson's disease usually occurs in about 2 days. However, in some patients, this medicine must be taken for up to 2 weeks before the full benefit is seen.

For patients taking amantadine to prevent or treat flu infections:

Talk to your doctor about the possibility of getting a flu shot if you have not had one yet. This medicine is best taken before exposure or right away after exposure to people who have the flu. To help keep yourself from getting the flu, keep taking this medicine for the full time of treatment. Or if you already have the flu, continue taking this medicine for the full time of treatment even if you begin to feel better after a few days. This will help clear up your infection completely. If you stop taking this medicine too soon, your symptoms may return. This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your doctor. If you are using the oral liquid form of amantadine, use a marked measuring spoon, oral syringe, or medicine cup to measure each dose correctly. The average household teaspoon may not hold the right amount of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing. You may take this medicine with or without food.

Take Osmolex ER™ extended-release tablet in the morning. Swallow whole. Do not crush, open, or chew it.

Do not receive the nasal flu vaccine (live attenuated influenza vaccine) while taking this medicine.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor. For oral dosage forms (extended-release tablets): Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor. For oral dosage forms (liquid-filled capsules, syrup, and tablets): Adults—100 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Older adults—At first, 100 milligrams (mg) once a day as a single dose. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For the treatment or prevention of flu: For oral dosage forms (capsules, syrup, and tablets): Adults—200 milligrams (mg) or 4 teaspoonfuls once a day as a single dose. Older adults—100 milligrams (mg) once a day as a single dose. Children 9 to 12 years of age—100 milligrams (mg) or 2 teaspoonfuls 2 times a day. Children 1 to 9 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4.4 to 8.8 milligrams (mg) per kilogram (kg) of body weight per day. The dose is divided evenly and given 2 times a day. However, the dose is usually not more than 150 mg per day. Children younger than 1 year of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Amantral and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Amantral dosage information

Side effects

The most common side effects associated with Amantral are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Be careful with Generic Amantral while you are pregnant or have nurseling. Generic Amantral can pass in breast milk and harm your baby. Do not use Generic Amantral if you are allergic to Generic Amantral components. Do not use FluMist nasal influenza "live vaccine" while you are being treated with Generic Amantral and for at least 48 hours after you stop taking Generic Amantral. The nasal vaccine may not be as effective if you receive it while you are taking Generic Amantral. Be careful with Generic Amantral if you have epilepsy or other seizure disorder, congestive heart failure, kidney or liver disease, low blood pressure, eczema, glaucoma, or a history of mental illness, suicide attempt, or drug/alcohol addiction. Be careful with Generic Amantral if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Generic Amantral if you take atropine (Atreza, Sal-Tropine, and others); dicyclomine (Bentyl); glycopyrrolate (Robinul); hyoscyamine (Anaspaz, Levbid, Levsin, Nulev, and others); mepenzolate (Cantil); methscopolamine (Pamine); propantheline (Pro-Banthine); scopolamine (Maldemar, Scopace, Transderm-Scop); quinine (Qualaquin); quinidine (Cardioquin, Quinaglute); diuretic (water pill) such as triamterene (Dyrenium), hydrochlorothiazide (HCTZ, Dyazide, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic); phenothiazines such as prochlorperazine (Compazine), thioridazine (Mellaril), and others. Avoid alcohol. Do not stop taking it suddenly.

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Influence of solution and gas phase processes on protein-carbohydrate binding affinities determined by nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry. Smectites are a group of 2:1-layer phyllosilicate minerals that have been extensively studied by small-angle x-ray scattering (SAXS) because of their industrial and environmental significance. V-shaped organic semiconductors with solution processability, high mobility, and high thermal durability. This is the second of a two-part article reviewing basic laboratory, imaging, endoscopic, urodynamic, and miscellaneous studies used for screening and diagnosis of urologic disease. We conducted a single-center, randomized, double-blind, placebo-controlled, two-period crossover study of 28-d treatment, with a 4-wk between-period washout. However, exposure to TGF-beta, increased glucose concentrations, or cyclic mechanical strain, all causal factors in glomerulosclerosis, markedly induced the expression of CTGF transcripts. Crossing the quality chasm: the role of information technology departments. Our results suggest that intermediates of unsaturated fatty acid oxidation that accumulate as a consequence of MCADD, MADD and VLCADD are transported to the endoplasmic reticulum for esterification into neutral glycerolipids.

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Measurement of pulse reappearance time in diagnosis of peripheral vascular disease in diabetes. The primary purpose of this study has been to validate the in vitro graft-vs.-host reaction as an experimental system. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, how much does danazol cost hematopoiesis, and calcium homeostasis. Studies of people serving in the South Korean military may provide information about the young adult male population in Korea. On the other hand, the CCE has revealed a very unstable aneurysm of the aorta which could be complicated during the cardiac catheterisation. It was possible to detect facial nerve dehiscence and defects in tegmen tympani in significant number of cases although, statistical values were low for these structures. Disturbances of the nutrient and hormonal regulation of glucocorticoid action in skeletal muscles might be relevant for metabolic diseases. Time-resolved chemiluminescence study of the TiO2 photocatalytic reaction and its induced active oxygen species. 62 hours later the first symptoms of a clostridial infection of the abdominal wall could be observed.

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Meningitis caused by Acinetobacter baumannii is rare and are mostly hospital acquired after neurosurgical procedure. The results indicate four xenon sites of occupancy from 0.45 to 1.0. Progesterone receptor expression is confined to urethral squamous epithelium and the major isoform is progesterone receptor A. Future research is needed to understand the reasons that previous pregnancy loss is associated with subsequent postpartum depression and anxiety among this population of women. Retroviruses code for a specific protease which is essential for polyprotein precursor processing and viral infectivity. Multivariate analysis demonstrated that large blood loss as well as operative curability B and adjuvant chemotherapy were independent risk factors for peritoneal recurrence and a worse outcome in advanced gastric cancer. Respondents were asked whether they could perform the activity without difficulty, with difficulty, or could not perform it at all.

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ATP-gated P2X(4) receptors (P2X(4)R) in macrophages and microglia have been implicated in neuropathic and inflammatory pain by currently unidentified mechanisms. Large areas of these tissues were absent for one-third of the circumference of the stele and extended 1.5 mm longitudinally along the root. PCR detection of Plasmodium falciparum in human urine and saliva what are the side effects of generic lipitor samples. A majority of tumours studied displayed SgIII immunostaining, which indicates a functional relationship with the other granins. These steps include species-specific cellular recognition, intracellular and intercellular membrane fusions, and enzyme-catalyzed modifications of cellular investments. Charnley total hip arthroplasty in ankylosing spondylitis: survivorship analysis of 76 patients followed for 8-28 years. Major operative injury initiates immunologic changes that may result in a systemic inflammatory response, leading to organ dysfunction/sepsis. In addition, this flap is always limited in length, which makes it hard to form the distal part of the nose.

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Modification of biodegradable poly(malate) and poly(lactic-co-glycolic acid) microparticles with low molecular polyethylene glycol. The KK/Ta mouse strain serves as a suitable polygenic model for human type 2 diabetes. Therefore, combining genetic, clinical and socio-demographic data is critical to understand the epidemiology of this infectious disease, and how virulence and other phenotypic traits evolve over time. Interstitial pulmonary diseases have recently been reported in workers from ITO producing plants. Our results suggest that SPR-positive cells are preserved while principal cells are present in the CA1 region, but show reactive changes in epilepsy including intense branching and growth of their dendritic arborization. Established quality indicators are appropriate for rural hospitals, but additional indicators need to be developed. At embryonic day 17.5, before the onset of these events, NMDAR1 knockout does not affect cell survival in either the BSTC or the VB. Mechanism of natriuresis during intrarenal infusion of prostaglandins. This finding suggests that the low pH stability of duck influenza A virus NA may be a critical factor for replication in the intestinal tract through the digestive tract of ducks, and that the properties of NAs are important for understanding the epidemiology of the influenza virus.

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The introduction of laparoscopic living-donor nephrectomy (LLDN) has made live donation more advantageous because of less postoperative pain, earlier return to normal activities, and a consequent potential to increase the pool of kidney donors. Our study provides evidence that it may be important for cell survival and transformation. After treated for 24h, PM10 showed the cytotoxicity in HLF and RAW264.7 cells, which was characterized by increase of the viability of cells at low concentration of PM10, and decrease at high doses. We traced the origin of aggressive PTLs occurring in six patients after allogeneic T cell-depleted stem cell transplantation (allo-SCT). However, the DNA-binding activity of this complex was not clearly defined.

amantadine review 2020-01-16

Although traditionally not taken into account by most of activated sludge models the production of nitrite as an intermediate of the nitrification-denitrification processes becomes of interest in some specific plant operational situations or in case of high sensitivity of the receiving ecosystems. These findings open new therapeutic avenues for the treatment of neurodegenerative disorders that specifically affect the striatum. Analysis of DNA degradation in the thymocytes of irradiated rats by flow cytometry. Juvenile systemic lupus erythematosus in multicase families from Saudi Arabia: comparison of clinical and laboratory variables with sporadic cases. Tobacco control campaigns should target uneducated and rural poor men and monitor all forms of tobacco used by the population. Interaction of Val108/158Met polymorphism with other genes and environmental factors is an important avenue for future research. They could be employed for assessing adolescent attitudes to these priority intervention areas, for carrying out studies on their mediating role on adopting behaviour, and for designing and evaluating health programs. Antimalarial activity of Aspilia pruliseta, a medicinal plant from Uganda. Revision rhinoplasty using porous high-density polyethylene implants to reestablish ethnic identity. (2) The clinical file on abciximab now includes three placebo-controlled trials.

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