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Apgel (Adapalene)

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Apgel is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Among topical retinoids used to treat acne vulgaris, Apgel is considered to be the least effective, but best tolerated.

Other names for this medication:
Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Ultram, Aldara, Lanoxin, Terramycin, Differin, Motilium, Luvox, Zantac, Flutiflo, Glimide, Alfacal, Renoxacin, Lipivim,

Also known as: Adapalene


Apgel (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Apgel is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Apgel dosage information

Side effects

The most common side effects associated with Apgel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of adapalene in the elderly with use in other age groups. Older adults are not likely to develop acne.

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Many hashing algorithms found their theoretic root in random projection. They also provide clear evidence for the involvement of LAD (E3) in the previously reported inactivation of PDHC by PLP. Disruption of social brain network connectivity and aberrant neuroendocrine function are identified as potential mechanisms of social impairments after pediatric TBI. Moreover, the findings question the validity of the current approach of medical treatment in which pegvisomant is used only when SSA therapy has failed to normalize IGF-I. NO increased in both experimentally induced PCDs, although with different intensities. The surgically resected tumor was histologically composed of chromophobe epithelial cell sheets and sarcomatoid elements. Not only do neopterin concentrations correlate with symptoms in the acute phase of Kawasaki syndrome, they also act as a predictive marker of coronary artery abnormalities in affected patients. Ultrasound-guided axillary block: anatomical variations of terminal branches of the brachial plexus in relation to the brachial artery.

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Fluid structural analysis of human cerebral aneurysm using their own wall mechanical properties. We now know that the requirements set for vitamin D intake were too low and not properly age adjusted. In experimentally induced cardiac ischaemia, the induction of HSP70s correlates with reduced infarct size and enhanced myocardial function and endothelial recovery. PNI is an independent adverse risk factor in the absence of nodal metastasis and extracapsular spread. Changing the course of pancreatic cancer--Focus on recent translational advances. Various chaperones and folding enzymes are involved in the folding and quality control of secretory proteins in the lumen. Electrodiagnostic results from 1,705 hands of patients with carpal tunnel syndrome (CTS) symptoms were reviewed retrospectively. Policies, operational framework and guidelines of the Inter-American Committee on Aquatic Animal Health.

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Pretreatment with 1,2-diazole prevented nephrotoxicity induced by cisplatin through a protective mechanism that involved reduction of increased oxidative stress by significantly increasing the enzymatic and non enzymatic antioxidant enzymes such as glutathione peroxidase (GPx), glutathione (GSH) and diminishing the lipid peroxidation (LPO). This exploratory descriptive study investigates the acculturation level, food intake, dietary changes and practices, health status perceptions, and diet-related health indicators-body mass index (BMI), waist and hip circumferences, and waist-to-hip ratio-of first-generation Filipino Americans (FAs) in Southern California. Clinical studies in accelerating the rate of tooth movement have similar findings observed in animal studies. We believe that infants, patients undergoing extracorporeal circulation, major abdominal, vascular, or neurosurgical procedures, or patients with a history of temperature regulatory problem are probably best monitored by a method which more exactly reflects core temperature. Mutations in six genes known to affect muscle structure were tested for suppression by representative sup-3 mutations.

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Here, we evaluate the evolution of specialization and generalization in 20 populations of Drosophila melanogaster experimentally evolved in constant and variable thermal environments for 3 years. The challenges of neonatal respiratory microbiome studies and future research directions are also discussed. Development and evaluation of flavi-immunoglobulin M capture enzyme-linked immunosorbent assay. Six observers underwent perimetric testing with the Humphrey Visual Field Analyzer (HFA) full threshold paradigm, and the output thresholds were compared to conditions where stimulus location was verbally cued to the observer. To achieve a broad protection, continual monitoring NoV epidemics and strain variations for selection of proper vaccine strains is critical. Dialysis guidelines in Japan recommend more frequent measurement of mineral metabolism markers than the Kidney Disease: Improving Global Outcomes guidelines. Whilst the polyclonal antisera showed that there was some diversity between them, all strains examined belonged to one serotype. Considerations on the annual register of rheumatic children, January 1, 1937-December 31, 1950. High glycolytic profile was significantly associated with poor prognosis in 20 metastatic, RAS-mutated pts treated with first-line chemotherapy plus Bevacizumab.

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For the frailest patients, CD20 monoclonal antibodies with or without chlorambucil have proven to be efficacious. Cytogenetic studies in three xenografted nasopharyngeal carcinomas. Collagen biosynthesis in cirrhotic rat liver slices a regulatory mechanism. Production of extensor hypertonus in differentiated extremities by low cadence stimulation of the anterior lobe of the cerebellum. Cissus quadrangularis stem ethanolic extract induces apoptosis and cell cycle arrest at G1 phaseIt liberates (ROS) and mitochondria mediated apoptosisIt upregulates p53 and down-regulates Bcl-2 protein expressionIn silico studies indicates that the active constituents of CQ binds Bcl-2 with higher affinity as compared to p53. Frontal activity during the digit symbol substitution test determined by multichannel near-infrared spectroscopy. When only a region of the muscle was paralysed a local hypertrophy of fibres was detected, and the change from SM1 to SM2 was most pronounced in the area where activity was blocked. This study aimed to assess VPT in symptomatic FAI pre- and 6-months post-arthroscopy vs. With a suture length: wound length ratio of 3 or 4 bursting pressure and bursting volume were lower with a continuous double loop closure. Therefore, a careful assessment for neurovascular injury mandatory.

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Oncologic outcome and patterns of recurrence after salvage radical prostatectomy. Aspergillus most often produces invasive pulmonary or sinus infection in severely immuno-compromised patients. Further analysis of this phenomenon and its psychosocial effects is needed to adequately allocate healthcare resources and to take preventive measures in the high-risk population. The objective of this article is to describe the clinical and microbiological aspects of this entity. In a group of Latin-Americans there is a predominance of diabetes mellitus, impaired glucose tolerance and obesity, while the rate of hypertension is unexpectedly low (lower than in the normal population).

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Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation. Comparison to commercial high-sensitivity immunoassays demonstrated that the chip-based assay provided fast, accurate, and precise measurements for the analytes under investigation. We searched for cross sectional and prospective studies in the general population and in the CKD population indexed in EMBASE, Pubmed, Web of Science, CINAHL, Cochrane and Ageline examining the association between frailty and CKD and those relating frailty in patients with CKD to clinical outcomes. Fowl are birds belonging to one of the 2 biological orders, the game fowl or land fowl (Galliformes) and the waterfowl (Anseriformes). To investigate whether ICE inhibition by HMR-3840 improves myocardial stunning in vivo.

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Altered expression of CYFIP1 is seen in other developmental disabilities, including 15q disorders, and haploinsufficiency of CYFIP1 in Type I PWS cases may be associated with age-related phenotypic effects. Leukencephalitis of diffuse sclerosis type (Schilder-Foix) with prolonged course. Here we describe two rapid and simple procedures increasing sensitivity by 1-2 orders of magnitude to visualize at least 1 x 10(-5) micrograms of single- and/or double-stranded DNA. This suppression did not occur in irradiated recipients, SCFS I cells injected into wattles of chickens immune to the tumor, provoked a local DH reaction. Soluble TNF and IL-6 receptors: indicators of vascular health in women without cardiovascular disease. InsP6 levels were diminished in transgenic potato plants constitutively expressing an antisense gene sequence for myo-inositol 3-phosphate synthase (IPS, catalysing the first step in InsP6 biosynthesis) or Escherichia coli polyphosphate kinase. Tolerance to the behavioural effects of physostigmine in rats: lack of importance of behavioural compensation.

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Viral myocarditis with infarct-like ECG findings in a 19-month-old boy. Since this potential is a slow brain potential, and baroreceptor activation is known to reduce slow brain potentials, it is plausible that baroreceptor activation primarily affects motor responses following slow but not fast perturbations. Messenger RNA synthesis in synchronized Chinese hamster ovary cells. The early detection strategies of incomplete remission and treatment resistance include re-evaluation of the diagnosis and optimization of pharmacological and non-pharmacological interventions including the treatment of co-morbid disorders. SiNW patterns with a width of 100 nm and height of 100 nm were fabricated on a p-type silicon-on-insulator (SOI) wafer by electron-beam lithography. The MK fusion protein extracted from the bacterial inclusion bodies with guanidine-HCl was renatured, refolded slowly and cleaved by thrombin at the site where the GST links to the MK. A 2-year-old girl with bilateral sensorineural deafness showed pontine hypoplasia as well as a bulging contour of the pontine tegmentum on magnetic resonance imaging (MRI). In addition, glucose induced active shedding of lipopolysaccharide, in turn triggering a strong induction of inflammatory cytokines in human macrophages.

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Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA) affect the productions of H2O2 and lipid peroxide (LPO), NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by N-acetylcysteine (NAC) and superoxide dismutase (SOD). The (13)C-UBT is a noninvasive method exhibiting high diagnostic accuracy with both UHR as well as DOB. A parallel-group randomized controlled trial was carried out, which compared IPANR intervention with routine 5Rs (control) at Fu Xing Hospital, Capital Medical University, Bei Jing, China. Undoubtedly, future iPSC-based applications in regenerative medicine will benefit from understanding how OCT4 functions. VEGF activated CRMP4 expression in gastric cancer cells, and this effect was significantly inhibited by MAPK and PI3K inhibitors (PD98059 and LY294002). Information about household characteristics was obtained by questionnaire. The iso-physiological copper concentration was determined as the bioavailable plasmatic copper in a healthy adult population. Challenges to accurate correlation include matching the pathology sectioning plane with the in vivo imaging slice plane and correction for the deformation that occurs between in vivo imaging and histology. At 4 weeks, GFAP-positive cells were observed in the connective tissue formed between the two nerve endings on the left side only. Our data suggest possible participation of the pericardial MCs in endocrine function of pericardium and in control of the ANP level in pericardial cavity.

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We conclude that IgM anti-sulfatide antibodies may have several different tissue binding patterns in the peripheral and central nervous systems. Throughout the newborn ferret cerebral cortex, a high amount of synaptophysin immunoreactivity was present within the marginal zone and subplate region. Then, the cluster analysis revealed five regimes of social cohesion. The effects of changes in plasma nonesterified fatty acid levels on oxidative metabolism during moderate exercise in patients with non-insulin-dependent diabetes mellitus. Comparative effects of exercise and isocapnic voluntary hyperventilation on pulmonary haemodynamics in chronic bronchitis and emphysema. A prospective study in pre- and postmenopausal women undergoing elective hysterectomy. In the present study, we investigated the role and preliminary mechanism of TPX2 in the resistance of lung squamous carcinoma to radiation therapy.

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As Latino children may experience higher rates of unmet needs, this article examines the current literature for the reasons for the disparity and the barriers to the utilization of mental health services for Latino children. The findings may indicate that high-anxiety individuals allocate attention to the target less efficiently and have reduced suppression of distractors compared to low-anxiety individuals who could suppress attention to the distractors more efficiently. Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. Ten (dermato)pathologists studied 50 cutaneous melanocytic lesions including common naevocellular naevi, dysplastic naevi (DN), melanomas in situ and invasive primary melanomas, with emphasis on the histological criteria of DN. Versican plays central roles in tissue morphogenesis and homeostasis and is implicated in the development of numerous diseases. Hematologic changes to 4 and one-half years of age in clinically normal beagles. 1 showed that monkeys with V4 lesions can regain their pre-operative levels of performance on hue discrimination tasks.

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Dormancy and glyoxylate metabolism was confirmed by the upregulated expression of dosR and icl, respectively, by intra-adipocyte bacilli compared with in vitro growing bacilli. Origin of the long-term variability and acceleration of FHR studied for the prevention of cerebral palsy in fetal hypoxia and general insults. Antisense oligonucleotide probe for HNF-3beta mRNA added daily to cultured E-14 cells blocked the HNF-3beta expression, but had no effect on the FP4 or TH expression. The sample used to study the BPSS comprised 70 patients with psoriasis vulgaris treated by climatotherapy at the Dead Sea. Angiogenesis is important for normal functioning of organism and its disturbances are observed in many diseases, called angiogenesis-related states. Hoarseness with typical signs on laryngoscopy is commonly thought to be caused by esophagopharyngeal reflux.

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Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton. Other precipitants of homelessness were acquired via observation and open-ended and structured questions. Device-related skin injury is a common cause of skin breakdown in the acute hospital environment. Drawing on qualitative research, it discusses the choice of plural therapeutic itineraries, including the use of informal and formal healthcare. The writers effectively applied on all three cases a radial removal of the lesion. A study was undertaken to determine whether changes in arterial oxygen tension affect levels of exhaled NO in humans. The temporal roles of brain-derived neurotrophic factor (BDNF) and fibroblast growth factor-2 (FGF-2) in the development of sensory neurons have been studied in a cell culture preparation which models normal embryonic inner ear development (normocytic).

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The National Heart, Lung, and Blood Institute guideline recommends that dosing racemic albuterol be administered every 1 to 4 hours for treating patients with asthma or chronic obstructive pulmonary disease (COPD) in the hospital. Comparative evaluation of the in vitro micronucleus test and the comet assay for the detection of genotoxic effects of X-ray radiation. Its pharmacological effects in malignant tumors, including gliomas, were speculated to involve neovascularization inhibition and vascular permeability. Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice. The development of chromatic and achromatic contrast sensitivity in infancy as tested with the sweep VEP. Because duplex scanning is the best method for detecting venous reflux, we only included reports that used this diagnostic modality. To obtain an efficient in vivo delivery method, we constructed a recombinant adenovirus expressing the IL-6 receptor superantagonist by inserting the cDNA, controlled by the RSV promoter, into a first generation replication-incompetent adenoviral vector. Our laboratory recently developed a risperdal consta 50 mg injection recombinant system for the synthesis of HPVs following immortalization of primary keratinocytes with cloned HPV-31 genomes (M.

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Smokers are more likely than non-smokers to meet current criteria for mental health conditions, such as mood disorders, anxiety disorders and psychosis. Clinical relevance The ACMC scores may serve as an indicator to predict the difficulties that the children may encounter in their home environment. Objective of this research was to investigate frequency of borreliosis on our material, to determine seasonal yearly distribution of disease and to investigate variability of clinical forms of disease. Conversely, inhibition of STAT3 using siRNAs or dominant negative mutants reduced KIM-1 expression in a kidney cancer cell line (769-P) that expresses high basal levels of KIM-1. Pemphigus mimicking common skin diseases--atypical presentation delaying correct diagnosis: case series of five patients.

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