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Celebrex

Celebrex is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID) which relieves pain and swelling (inflammation). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.

Other names for this medication:
Celact, Celcib, Celcox, Celebix, Celecap, Celecoxib, Celedol, Celemax, Celetop, Celexax, Celfast, Celib, Celira, Cobix, Colcibra, Coxib, Eloxib, Orthocel, Orthocell, Revibra, Sionara, Zecoxib, Zycel

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Also known as: Celecoxib

Description

Celebrex (celecoxib) is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Celebrex is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.

Celebrex is used to treat juvenile rheumatoid arthritis in children who are at least 2 years old. It is also used in the treatment of hereditary polyps in the colon.

Dosage

Usual Adult Dose for Pain:

Acute pain: 400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.

Usual Adult Dose for Dysmenorrhea:

400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.

Usual Adult Dose for Osteoarthritis:

200 mg orally once daily or 100 mg orally twice daily.

Usual Adult Dose for Rheumatoid Arthritis:

100 to 200 mg orally twice daily.

Usual Adult Dose for Familial Adenomatous Polyposis:

400 mg orally twice daily with food.

Usual Adult Dose for Ankylosing Spondylitis:

200 mg orally once daily or 100 mg orally twice daily. If after 6 weeks of therapy no results are observed, a trial dose of 400 mg orally daily may be worthwhile. If no response is seen after 6 weeks, consideration should be given to alternate treatment options.

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

2 years or older: 10 to less than or equal to 25 kg: 50 mg orally twice daily Greater than 25 kg: 100 mg orally twice daily

Detailed Celebrex dosage information

Overdose

If you overdose Generic Celebrex and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Celebrex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Celebrex if you are allergic to celecoxib, or if you have:

an allergy to sulfa drugs; or a history of asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

a stomach ulcer, bleeding in your stomach or intestines; heart disease, high blood pressure; asthma; bleeding problems; liver or kidney disease; or if you smoke or drink alcohol.

If you are pregnant, you should not take Celebrex unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

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The sites of absorption of increasing doses of I-labelled triolein in the rat. Angiotensin II receptor subtypes: characterization, signalling mechanisms, and possible physiological implications. To elucidate the structural constituents of sodium nitroprusside responsible for antiaggregating effects, comparative studies were done with pentacyanoferrates possessing ligands other than nitric oxid. Cutaneous sympathetic vasoconstrictor reflexes for the evaluation of interscalene brachial plexus block. This procedure demonstrates the generation of significant episodes of new genetic variation arising at specific intervals during ontogeny. The ability to express exogenous cDNAs while suppressing endogenous genes via RNAi represents an extremely powerful research tool with the most efficient non-transient approach being accomplished through stable viral vector integration. The fresh root weight decreased when treated with 50-100mg/l graphene oxide.

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The strong American influence on the philosophy and everyday actions of Dutch neurosurgeons continues until this day. However, the molecular knowledge of how surrounding lipids affect membrane transport is surprisingly limited and despite its general importance is rarely considered in the molecular description of a transport mechanism. The plavix medication names Enterobacteriaceae, as well as glucose non-fermenting Gram-negative bacilli, remain outside the therapeutic range of the new macrolides, as they were for the established compounds. Here, we provide evidence that HPr interacts with a large number of proteins in Escherichia coli We demonstrate HPr-dependent allosteric regulation of the activities of pyruvate kinase (PykF, but not PykA), phosphofructokinase (PfkB, but not PfkA), glucosamine-6-phosphate deaminase (NagB), and adenylate kinase (Adk). We found that the wild-type p53 physically interacted with ER in vivo and repressed the estrogen-activated transcriptional activity. The abnormal level of HPS, either too high or too low, may correlate to respective pathologies.

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