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Cymbalta (Duloxetine)

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Cymbalta is used to treat depression and anxiety. It is also used to help relieve nerve pain (peripheral neuropathy) in people with diabetes. It is also used to help relieve ongoing pain due to medical conditions such as arthritis or chronic back pain

Other names for this medication:
Combac, Delok, Deneurone, Detine, Dulane, Dulex, Dulife, Dulojoy, Dulok, Dulomax, Dulonix, Dulot, Dulotin, Duloxee, Duloxit, Duloxyl, Dulti, Duonex, Dureep, Duzac, Duzela, Nudep, Sylonex, Symbal, Sympta, Ulozet, Xeristar

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Also known as: Duloxetine


Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression.

Cymbalta is used to treat major depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

Cymbalta is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).

Cymbalta is also used to treat fibromyalgia (a chronic pain disorder) in adults and children at least 13 years old.


Swallow a capsule whole with a drink of water. For depression and diabetic neuropathic pain: 60 mg once a day. Your doctor should determine the dose that is right for you. For generalised anxiety disorder: 30 mg once a day after which most patients will receive 60 mg once a day. Your doctor should determine the dose that is right for you. The dosage may be adjusted up to 120 mg a day based on individual response to Cymbalta. Take capsules at the same times every day. Talk with your doctor about how long you should keep taking Cymbalta. Do not stop taking Cymbalta, or change your dose, without discussing with your doctor. Cymbalta starts to work in most cases of depression or anxiety within 2 weeks of starting taking, but it may take 2-4 weeks before you feel better. Tell your doctor if you do not start to feel better after this time.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, dizziness or drowsiness, seizures, fast heartbeats, fainting, or coma.


Store at a room temperature between 4 and 30 degrees C (39 and 86 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cymbalta are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Cymbalta if you are allergic to duloxetine.

Do not take Cymbalta within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with duloxetine could cause a serious condition called serotonin syndrome.

Cymbalta is not approved for use by anyone younger than 7 years old.

To make sure this medicine is safe for you, tell your doctor if you have:

heart problems, high blood pressure; liver or kidney disease; slow digestion; a seizure; bleeding problems; narrow-angle glaucoma; bipolar disorder (manic depression); drug addiction or suicidal thoughts; or if you drink large amounts of alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking an SNRI antidepressant during late pregnancy could increase your risk of excessive bleeding after you give birth, and may cause serious medical complications in the baby. However, stopping the medicine may not be safe if you have a relapse of depression. Do not start or stop taking this medicine without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of duloxetine on the baby.

If you are breastfeeding, tell your doctor if you notice drowsiness, feeding problems, and slow weight gain in the nursing baby.

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Analysis of the microbiological quality and potential presence of Listeria monocytogenes in custard apple (Annona muricata), mango (Mangifera indica) and passion fruit (Passiflora edulis) pulps from Costa Rica. Although higher blood pressures are generally recognised to be an adverse prognostic marker in risk assessment of cardiology patients, its relationship to risk in chronic heart failure (CHF) may be different. HeartMate 3 implantation via left lateral thoracotomy with outflow graft anastomosis to the descending aorta. Salvage irrigation-suction in gracilis muscle repair of complex rectovaginal and rectourethral fistulas. In large part, we suggest, fluid intelligence may reflect this process of converting complex requirements into effective attentional episodes. Replication of the exact three-dimensional (3D) structure of the maxilla and mandible is now a priority whilst attempting reconstruction of these bones to attain a complete functional and aesthetic how much does risperdal cost without insurance rehabilitation. An imipenem-resistant mutant of Proteus mirabilis lacked a 26 kDa outer membrane protein (OMP). To date, autologous disc chondrocytes have not been transplanted into degenerative discs without previous disc herniation.

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