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Differin (Adapalene)

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Differin and Differin (Retin-A) are different medications, but they are both used to treat mild-to-moderate acne. Differin contains adapalene, and Retin-A contains Differin. They both offer a range of benefits and options, so talk to your healthcare provider to discuss which one would be the best fit for you.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

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Dilantin, Feldene, Ultram, Klonopin, Celebrex, Nolvadex, Prandin, Benzix, Domol, Sildenafilum, Albenic, Aldazole, Niften, Labetalolo, Vagonorm,

Also known as: Adapalene


Differin is a third-generation topical retinoid primarily used in the treatment of acne. Differin is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Differin gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Differin works under the skin surface to unclog pores and clear up pimples. Differin is also known as Adapalene, Adapen, Adaferin. Generic name of Differin is Adapalene.


Usual Adult Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Differin dosage information


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Differin dosage information

Side effects

The most common side effects associated with Differin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Differin if you are allergic to Differin components. It is not known whether Differin will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Differin in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Differin, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Differin. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Differin suddenly.

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