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Difra (Adapalene)
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Difra

Difra is a retinoid. While experts aren't exactly sure how it treats acne, they believe it works by stopping pimples from forming under the skin and lowering the amount of redness and inflammation on the skin.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

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Decadron, Parlodel, Adipex, Skelaxin, Zovirax, Nimotop, Aurogra, Zyvox, Astelin, Zyclara, Dolomed, Randic, Amaryl, Proval, Ibuprom, Omepren,

Also known as: Adapalene

Description

Difra is a third-generation topical retinoid primarily used in the treatment of acne. Difra is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Difra gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Difra works under the skin surface to unclog pores and clear up pimples. Difra is also known as Adapalene, Adapen, Adaferin. Generic name of Difra is Adapalene.

Dosage

Follow the directions for using this medicine provided by your doctor. Use Difra exactly as directed. Difra is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Difra. Difra should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Difra. Continue using Difra until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Difra promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.

Overdose

If you overdose Difra and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Difra dosage information

Side effects

The most common side effects associated with Difra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of adapalene in the elderly with use in other age groups. Older adults are not likely to develop acne.

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Purified beet-syrups concentrated under vacuum or under atmospheric pressure showed more stability during storage than sugar cane syrup. To identify the risk factors for dTSH development among newborns in the NICU. Additionally, mediator-specific changes in the kinetics and magnitude of C/EBP mRNA expression pattern and profile of DNA-protein interactions were observed. This could have had far-reaching and dangerous consequences for the patient, which were fortunately averted. To evaluate the feasibility and effectiveness of a preventive programme for haemoglobinopathies in a single centre in Northeastern Iraq. Analysis of otoacoustic emissions in neonates at term and preterm. Co-distribution of type VI and type IV collagens in human muscle was demonstrated using double labeling immunofluorescent microscopy and immunoelectron microscopy. We applied mixed models analysis, regression analysis and trajectory analyses. In patients with lung neoplasms considered eligible for surgical resection, (18)F-FDG PET/CT versus contrast-enhanced CT revealed higher sensitivity in nodal staging, but lower specificity both in lesion characterization and nodal staging.

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Superior function of a bicuspid over a monocuspid patch for reconstruction of a hypoplastic pulmonary root in pigs. Although the frequency is low, diagnosis of fibrocalculous pancreatic diabetes must be kept in mind in treating diabetic subjects in developing countries as its management would include management of pain, pancreatic enzyme supplements and periodic surveillance for pancreatic malignancy. Distribution of lipid biomarkers on tissues was explored by imaging mass spectrometry. There is still a considerable need to increase awareness of the rare autoimmune blistering diseases, which often show a severe, chronic-relapsing course, among physicians and the public. To avoid the use of amine protecting groups a Click-chemistry based modular synthesis of novel hydrophilic as well as amphiphilic cell penetrating peptoids was developed to generate novel structures for drug delivery in cells. Impact on medical students of incorporating GALS screen teaching into the medical school curriculum.

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To determine the effectiveness of a Navigation programme for patients with traumatic brain injury. The expected benefits of the use of POCT are individual (better knowledge of HCV status, better access to care and treatment) but also collective (reduction of morbidity and mortality related to HCV and its cost in terms of public health) Because of their clinical interest, POCT should be refunded as well as the currently recommended screening test. To characterize the pharmacokinetics of dexmedetomidine when administered as a short intravenous (IV) infusion to isoflurane-anesthetized rabbits. An antiserum directed against the host-encoded RdRp from cowpea leaves was applied to examine a possible role of this enzyme in cowpea mosaic virus (CPMV) RNA replication. To investigate the clinical characteristics and curative effect in 61 adult patients with acute lymphoblastic leukemia (ALL). Clinical analysis of forty-two cases and the report of a case with neurological complication.

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Large-scale proteomic profiling of biological samples such as cells, organelles or biological fluids has led to discovery of numerous key and novel proteins involved in many biological/disease processes including cancers, as well as to the identification of novel disease biomarkers and potential therapeutic targets. Development of reflective judgement in the pre-doctoral dental clinical curriculum. Reduced clearance of proteins labeled with diisopropylfluorophosphate in portacaval-shunted rats. The experiments have been performed at 0.2 and 0.1 eV above threshold, and both double and triple differential cross sections have been extracted. We have encountered a 12-year-old boy with a pacemaker implanted in the left pleural space during early infancy that migrated into the stomach through the diaphragm due to severe scoliosis and occult infection.

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