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Difra (Adapalene)

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Difra is a retinoid. While experts aren't exactly sure how it treats acne, they believe it works by stopping pimples from forming under the skin and lowering the amount of redness and inflammation on the skin.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Decadron, Parlodel, Adipex, Skelaxin, Zovirax, Nimotop, Aurogra, Zyvox, Astelin, Zyclara, Dolomed, Randic, Amaryl, Proval, Ibuprom, Omepren,

Also known as: Adapalene


Difra is a third-generation topical retinoid primarily used in the treatment of acne. Difra is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Difra gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Difra works under the skin surface to unclog pores and clear up pimples. Difra is also known as Adapalene, Adapen, Adaferin. Generic name of Difra is Adapalene.


Follow the directions for using this medicine provided by your doctor. Use Difra exactly as directed. Difra is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Difra. Difra should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Difra. Continue using Difra until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Difra promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


If you overdose Difra and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Difra dosage information

Side effects

The most common side effects associated with Difra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of adapalene in the elderly with use in other age groups. Older adults are not likely to develop acne.

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Purified beet-syrups concentrated under vacuum or under atmospheric pressure showed more stability during storage than sugar cane syrup. To identify the risk factors for dTSH development among newborns in the NICU. Additionally, mediator-specific changes in the kinetics and magnitude of C/EBP mRNA expression pattern and profile of DNA-protein interactions were observed. This could have had far-reaching and dangerous consequences for the patient, which were fortunately averted. To evaluate the feasibility and effectiveness of a preventive programme for haemoglobinopathies in a single centre in Northeastern Iraq. Analysis of otoacoustic emissions in neonates at term and preterm. Co-distribution of type VI and type IV collagens in human muscle was demonstrated using double labeling immunofluorescent microscopy and immunoelectron microscopy. We applied mixed models analysis, regression analysis and trajectory analyses. In patients with lung neoplasms considered eligible for surgical resection, (18)F-FDG PET/CT versus contrast-enhanced CT revealed higher sensitivity in nodal staging, but lower specificity both in lesion characterization and nodal staging.

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Significance of vascular endothelial growth factor--VEGF--in tumor angiogenesis. To understand the structural requirements of HDAC inhibitor selectivity and develop isoform selective HDAC inhibitors, SAHA analogs modified in the linker at the C5 position were synthesized and tested for potency and selectivity. The effect sizes associated with these group differences in ISV were marginally greater than the effect sizes for the comparisons of the group means. Toward Mentoring in Palliative Social Work: A Narrative Review of Mentoring Programs in Social Work. The role of the physician in the preparation of adults for old age. The formation of secure new attachments by children who were maltreated: an observational study of adolescents in foster care. Subacute paraparesis induced by venous thrombosis of a spinal angiolipoma: a case report.

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Low-dose lactose in drugs neither increases breath hydrogen excretion nor causes gastrointestinal symptoms. A coupled regression model was developed to describe the transfer of metals from soil to solution and plant shoots. Thus, the two sides of the debate about the role and evolution of secondary metabolism can be accommodated within the view that the possession of secondary metabolism can enhance fitness, but that many products of secondary metabolism will not enhance the fitness of the producer. A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity. In addition, we present evidence that pulsatile delivery of oxytocin into the circulation is important for the efficient progress of parturition, indicating that a major role of the neuronal circuits regulating oxytocin secretion for parturition, as is already known for suckling, is to produce an appropriately patterned hormonal output for efficient biological action. Norepinephrine and schizophrenia: a new hypothesis for antipsychotic drug action.

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