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Fasigyn (Tinidazole)
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Fasigyn

Fasigyn 500mg film-coated tablets contain 500mg of the active substance tinidazole. This medicine is an anti-infective agent. It is used to treat a variety of bacterial infections. It is also used before certain surgical operations to prevent bacterial infections developing.

Other names for this medication:
Simplotan, Tindamax, Tinidazole

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Also known as: Tinidazole

Description

Fasigyn manufacturer is Pfizer. Fasigyn tablets contain active ingredient is Tinidazole, a 5-nitroimidazole anti-parasitic agent, which belongs to a drug class Amebicides, Antimalarials and gynecological Antiinfectives.

Dosage

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

Take Fasigyn with a glass of water during or after a meal. Swallow the tablets whole. It is best to take the medicine at the same time each day.

For bacterial infections, this medicine is not recommended for use in children less than 12 years as it has not been tested in this age group.

For protozoal infections, Fasigyn 500mg film-coated tablets can be used in children and has not been shown to cause any different side effects or more problems than it does in adults.

The dose and length of treatment depends upon the infection being treated. If you are on dialysis, your doctor may prescribe a different dose.

The doses most commonly used for the different infections are shown in the table below:

For treating the infection associated with stomach ulcers. The usual dose is 1 tablet (500mg) taken twice a day. Your doctor will probably prescribe two other medicines to be taken with Fasigyn 500mg film-coated tablets. Treatment with the three medicines together will usually be for 1 week.

For treating most bacterial infections. The usual dose is 4 tablets (2g) on the first day then 2 tablets (1g) once a day or 1 tablet (500mg) twice a day. The usual length of treatment is 5 to 6 days.

For treating bacterial vaginitis (a vaginal infection) and acute ulcerative gingivitis (a gum infection). The usual dose is 4 tablets (2g) given as a single dose. For vaginitis you may be given 4 tablets (2g) on two consecutive days.

For preventing bacterial infections after surgery. Usually 4 tablets (2g) are given as a single dose about 12 hours before surgery.

For treating protozoal infections. For treating intestinal amoebiasis (a stomach infection). Adult: The usual dose is 4 tablets (2g) once a day for 2 to 3 days. Child: The usual dose is 50 to 60mg/kg of body weight once a day for 3 days.

For treating amoebic involvement of the liver (a liver infection). Adult: The usual dose is 3 to 4 tablets (1.5 to 2g) once a day for 3 to 6 days. Child: The usual dose is 50 to 60mg/kg of body weight once a day for 5 days.

For treating giardiasis (an abdominal infection) and trichomoniasis (an infection of the sex organs in males and females). Adult: The usual dose is 4 tablets (2g) given as a single dose. Child: The usual dose is 50 to-75mg/kg of body weight given as a single dose.

Your doctor will calculate the dose required for a child and may repeat the dose once if the infection has not cleared up completely.

Overdose

In acute animal studies with mice and rats, the LD50 for mice was >3600mg/kg and >2300mg/kg for oral and intraperitoneal administration respectively. For rats, the LD50 was >2000mg/kg for both oral and intraperitoneal administration.

Signs and symptoms of overdosage: There are no reported overdoses in humans with Fasigyn.

Treatment for overdosage: There is no specific antidote for treatment of overdosage with tinidazole. Treatment is symptomatic and supportive. Gastric lavage may be useful. Tinidazole is easily dialysable.

Storage

Keep all medicines out of the sight and reach of children.

Do not take this medicine after the expiry date stamped on the pack after EXP. The expiry date refers to the last day of that month.

Store below 25 C in a dry place. Store in the original package to protect from light and moisture.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Side effects

The most common side effects associated with Fasigyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Pregnancy: Fertility studies in rats receiving 100mg and 300mg tinidazole/kg had no effect on fertility, adult and pup weights, gestation, viability or lactation. There was a slight, not significant, increase in resorption rate at the 300mg/kg dose. Tinidazole crosses the placental barrier. Since the effects of compounds of this class on foetal development are unknown, the use of tinidazole during the first trimester is contraindicated. There is no evidence that Fasigyn is harmful during the latter stages of pregnancy, but its use during the second and third trimesters requires that the potential benefits be weighed against possible hazards to mother or foetus.

Breast-feeding: Tinidazole is excreted in breast milk. Tinidazole may continue to appear in breast milk for more than 72 hours after administration. Women should not nurse until at least 3 days after having discontinued taking Fasigyn.

No special precautions should be necessary. However, drugs of similar chemical structure, including Fasigyn, have been associated with various neurological disturbances such as dizziness, vertigo, ataxia, peripheral neuropathy (paraesthesia, sensory disturbances, hypoaesthesia) and rarely convulsions. If any abnormal neurological signs develop during Fasigyn therapy, the drug should be discontinued.

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Self-esteem and socioeconomic disparities in self-perceived oral health. A multivalent anti-Rh(D) recombinant protein has been designed by reconstructing the antibody binding site of a human monoclonal anti-Rh(D) antibody as a single chain Fv mini antibody, then multimerizing it by inserting at its C-terminal end the C-terminal part of the C4 binding protein (C4bp) alpha chain, which is responsible for the octamer multimerization of that molecule. A total of 183 patients were randomly assigned to receive daily doses of either placebo, or 80 mg seratrodast, or 120 mg seratrodast for 8 weeks. Nitric oxide from polymorphonuclear leukocytes modulates red blood cell deformability in vitro. The structural and functional motor-system integrities appear to be dissociated between ALS and bvFTD, which represents useful information for the diagnosis of motor-system changes in these two disorders. We propose a top-down approach to the symptoms of obsessive-compulsive disorder (OCD) based on a statistical dynamical framework. Reconstruction of maxillary sinus superior wall fractures with calcium phosphate cement/recombinant human bonemorphogenetic protein 7 compound implanted material in rabbit.

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Clinically, H2 gas inhalation is expected to stabilize the subject until curative treatment can be performed, thereby increasing the probability of survival after hemorrhagic shock. In addition, these mice exhibit protection from streptozotocin-induced diabetes and enhanced insulin sensitivity with improved glucose uptake and insulin-dependent glucose disposal by skeletal muscle. DEALING WITH CONFLICT AND INCIVILITY AS A NURSING STUDENT AND AS A PROFESSIONAL RN. In the present study, we examined whether immunocytochemical evidence of interaction between GABAergic neurons and the mu-opioid receptor could be found in the CNS. Linkage analysis in German breast cancer families with early onset of the disease by using six markers on chromosome 17q11-q24 has been carried out. A single-group pre/post design in which participants attended a twice-weekly Tai Ji Quan training program for 24 weeks. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr) of SQTS, results from an inactivation-attenuated, gain-of-function mutation (N588K) in the KCNH2-encoded potassium channels. Application of a new covered endoprosthesis in the treatment of occlusive and aneurysmal peripheral arterial diseases.

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The porcine model thereby represents a novel method to study the impact of endovascular, cell-based, and other therapeutic interventions on AAA pathophysiology. Thus the SHRP most accurately refers to HPA axis insensitivity to stress because the brain itself readily responds to stress as evidenced by the induction of IEGs. Under these conditions, CytoD also promoted the rapid proteolytic breakdown of the 63 kDa pro form of MT1-MMP, resulting in the appearance of the 43 kDa MT1-MMP processed form. One-way ANOVA and post hoc analysis were used to compare baseline glycosylated hemoglobin (HbA1C) values with subsequent values. The augmentation of 5-HT(1B) receptor-mediated contractions may be of relevance in pathophysiological conditions such as variant angina and preeclampsia, where the development of 5-HT(1B) receptors seems to be expedited. This long term follow up of lung disease in primary SS is reassuring, and suggests that most patients do not develop progressive lung disease. Projected demand for occupational employment is significantly affected by the projected employment for industries. Segmental and suprasegmental mechanisms of the protection phenomenon at the thoracic level of the spinal cord. Despite several potential therapeutic agents against astrocytoma and glioblastoma, there are currently no effective therapies for astrocytoma, creating a great need for the identification of effective antitumor agents.

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Despite this, she survived more than 10 years and was later correctly diagnosed by VATS of the pleural lesions and based on a review of the previous pathology. The program assures access to modern genomic oncology practice in the veterans affairs (VA), removes disparities of access across the VA network of clinical centers, disseminates the products of learning that are generalizable to non-VA settings, and systematically presents opportunities for patients to participate in clinical trials of targeted therapeutics. To describe a remote positioning system for accurate and efficient proton radiotherapy treatments. Very significant QSPR diffusion models were constructed for all three gases. Genomics era techniques such as microarrays and proteomics have great potential to increase our understanding of how foodborne pathogens grow and survive within animal and human hosts, in the environment and foods, and during thermal and nonthermal inactivation protocols. Neutralization and demulcification are recommended but no time should be lost if weak alkali is not readily available. In conclusion, recognition via SRA by dendritic cells is likely to play a central role in the immune response to N.

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3H-leucine uptake of developing hypothalamic nuclei in rats and its fluctuation after ovariectomy. Alcohol administration activates the hypothalamic-pituitary-adrenal (HPA) axis of both male and female rats, with females secreting more adrenocorticotropin (ACTH) and corticosterone than males in response to the same dose of alcohol. Calculating three-dimensional molecular structure of paliurine B from atom-atom distance and restrained energy minimization. When the aim is to study cognitive processes very often the researcher uses attributes of the learning material to be the standard or the template against which any outcome of the subjects can be analysed and made the ground for inferences about cognition and cognitive processes. Influence of hyperkalaemia and ischaemia on non-receptor-mediated cardiac electrophysiological effects of naloxone. Superficial fibular nerve and deep fibular nerve stimulations apparently resulted in nonnutritional circuit constriction with resulting blood flow redistribution to nutritional circuits, possibly located in tissues other than the skin, e.g., adipose tissue. Plantations could also contribute to the conservation of biodiversity by providing an environment for the cultivation of forest herb species as an alternative to their destructive harvest from natural populations. Adenoviral gene transfer to the injured spinal cord of the adult rat. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group.

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Plants are traditionally used for management of diseases including diabetes. Here, both effects are described analytically, and predicted values for measured transport during laminar flow through a straight, 3.2-mm diameter pipe are validated using two-dimensional (2D) constant-time images of different binary gas mixtures. Evidence is presented that multiple copies of one epitope or a series of closely related epitopes exist on the polyhedrin molecule. Best corrected visual acuity and intraocular pressure measurements were taken during each examination. One year later, Wechsler Adult Intelligence Scale-Third Edition and Wechsler Memory Scale-Revised scores reached normal levels.

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Histopathological study of the operating material brought to light the origin of the change. Discovery of Specific Antigens That Can Predict Microfilarial Intensity in Loa loa Infection. Antagonism of the behavioral effects of morphine and methadone by narcotic antagonists in the pigeon. Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes. (Intense Pulsed Light) laser following unsatisfactory response with dermabrasion. Acquired EDV is less commonly reported in recipients of stem cell or solid organ transplantation. However, the maturation of dendritic cells may not be inhibited by AhR activation. In cardiovascular disease, arterial hypertension, diabetes, migraine, and Parkinson disease, the methodology of studies was poor, but an association might be possible. Single-use NPWT for the treatment of complex orthopaedic surgical and trauma wounds.

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These include the possible role of T cell-mediated cytotoxicity as well as the interaction between the IgA class of antimitochondrial antibodies and the mitochondrial autoantigens. Prognostic nomogram for patients with non-B non-C hepatocellular carcinoma after curative liver resection. Since March 2010, almost all oocytes for donation are vitrified in our centre. The article presents the results of treatment of 13 women with erosion of the vaginal mucosa with an exposure of the part of prosthesis and 4 women with the migration of fragments of the prosthesis into the lumen of the bladder or urethra after surgical correction of genital prolapse and stress urinary incontinence with the use of synthetic materials (Prolift, TVT operations). An unstable diiron(II,II) complex possessing O2 binding ability at low temperature was encapsulated and stabilized in an ammonium-type ionic liquid layer polymerized on an electrode. The accumulated functional neuroimaging findings in mood disorders were reviewed in order to examine a proposed neuroanatomic model of pathophysiology. The last decade witnessed a significant increase in epidemic activity of human enterovirus 71 (EV71) in the Western Pacific Region (WPR).

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Falls and fall prevention in the elderly: the Jamaican perspective. Folding of DNA by histones which lack their NH2-terminal regions. However, both groups had large improvements in self-reported function and ankle strength. Species richness, functional diversity and phylogenetic diversity decreased during construction and the first stage of operation. However, unlike most mammalian species, there does not appear to be frequent gene conversion between the MT and AVT cDNA sequences. Post-treatment effect of isoniazid preventive therapy on tuberculosis incidence in HIV-infected individuals on antiretroviral therapy. Shh plays an important role in adult hippocampal neurogenesis, and its downstream signaling components regulate the synthesis of Wnt proteins. Here report a case of successful surgical repair of ascending aortic dissection complicated with aorto-right atrium fistula. A pharmacist-developed and -administered vitamin D educational intervention increased the proportion of participants achieving sufficient vitamin D concentrations, increased the self-reported daily vitamin D intake, and lowered serum parathyroid hormone concentrations. P84 is a neuronal membrane glycoprotein that promotes the attachment and neurite outgrowth of cultured murine cerebellar cells.

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