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Glucotrol

Glucotrol is a medicine used to treat type 2 diabetes mellitus in adults. It belongs to a group of medicines called sulfonylureas and helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness.

Other names for this medication:
Actizide, Bimode, Diabizide, Diacon, Diaglip, Dibimet, Dibizide, Glanase, Glibetic, Glicept, Glimet, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipitis, Glipixor, Glipized, Glipizide, Glipmet, Glucolip, Gluconil, Glumin, Glunas, Glycind, Glydal, Glylin, Glynase, Glysar, Glysin, Glyson, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Metglib, Swiglip, Tranase, Zidmin

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Also known as: Glipizide

Description

Glucotrol is a medication consists in a class of drugs called sulfonylureas. Glucotrol is used to treat type 2 diabetes. Glucotrol may be used along with diet, exercise and insulin therapy. Glucotrol is also known as Glipizide, Glytop SR. Glucotrol works by controlling blood sugar levels in your organism. Generic name of Glucotrol is Glipizide. Brand names of Glucotrol are Glucotrol, Glucotrol XL.

Dosage

Usual Adult Dose of Glucotrol for Diabetes Type 2:

Immediate release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg Comments: -At least several days should elapse between titration steps. -If response to a single dose is not satisfactory, dividing that dose may prove effective. Extended Release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: 5 to 10 mg orally once a day Maximum daily dose: 20 mg Patients receiving immediate release may be switched safely to extended release tablets once-a-day at the nearest equivalent total daily dose, or titrate to the appropriate extended release dose starting with 5 mg once daily. Combination use: -When adding other blood-glucose-lowering agents to the extended release tablets, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. -When adding extended release tablets to other blood-glucose-lowering agents, Glucotrol XL extended release can be initiated at 5 mg. Start at a lower dose in patients that are more sensitive to hypoglycemia. When transferring patients from insulin to glipizide, the following general guidelines should be considered: -For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. -For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Comments: -Several days should elapse between titration steps. -Subsequent reductions in insulin dosage should depend on individual patient response. -During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. -Some patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period. Patients Receiving Other Oral Hypoglycemic Agents: -When transferring from longer half-life sulfonylureas: Observe for 1 to 2 weeks for hypoglycemia. -Glucotrol XL extended release coadministered with colesevelam: Glipizide should be administered at least 4 hours prior to colesevelam. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose of Glucotrol for Diabetes Type 2:

Initial dose: 2.5 mg orally once a day 30 minutes before breakfast Comments: -Maintenance dosing should be conservative to avoid hypoglycemic reactions. -Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Glucotrol dosage information

Overdose

If you overdose Glucotrol and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Glucotrol overdosage: hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, coma.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Glucotrol XL dosage information

Side effects

The most common side effects associated with Glucotrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid drinking alcohol. It lowers blood sugar and can cause side effects.

Avoid driving or operating machinery until you know how glipizide will affect you.

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Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells. Dissolved organic matter (DOM), is the most active fraction of soil organic matter and may contain compounds affecting plant establishment, as allelochemicals, hormone-like substances and metal carriers. Carbachol produced a relaxation of dilator muscle at a concentration lower than 1 microM and a contraction at a concentration higher than 1 microM. She was discharged for follow-up, but her clinical course was that of a relentless deterioration. Here, we show that MKK3 interacts with a large number of proteins critical for cell growth and metabolism, including the major oncogenic driver MYC. Donovanosis of tubes and ovary treated with aureomycin and surgery. Incidence and therapeutic implications of synchronous colonic pathology in colorectal adenocarcinoma.

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Evaluate substance use (tobacco, alcohol, psychotropic drugs, illicit drugs) declared before and during pregnancy. Brief and chronic exposure of rats to neostigmine methylsulfate produced marked morphological alterations of the fine structure at the end-plate region of the extensor digitorum longus muscles. Multidetector-row computed tomography angiography in abdominal aortic aneurysm treated with endovascular repair: evaluation of optimal timing of delayed phase imaging for the detection of low-flow endoleaks. Certain electrocardiographic (ECG) abnormalities are associated with ischemic stroke (IS), especially cardioembolic subtype. This prompts an urgent need to investigate the molecular mechanisms underlying the evolution of therapy-induced resistance of prostate cancer either in the form of castration-resistant prostate cancer (CRPC) or transdifferentiated neuroendocrine prostate cancer (NEPC). It has been proposed that the normal heartbeat may display complex nonlinear dynamics, including deterministic chaos, and that such cardiac chaos may be a useful physiological marker for the diagnosis and management of certain heart trouble. CD27 expression and its association with clinical outcome in children and adults with pro-B acute lymphoblastic leukemia.

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This study provides a proof-of-concept demonstration that app-based biofeedback is a viable alternative to costlier dedicated systems. To determine whether modification of (A-I w/o A-II) r-HDL with apo A-II altered the structure of the r-HDL, the packing of phospholipids in the modified and unmodified particles was compared by steady state fluorescence polarization and the environments of the apo A-I tryptophan residues in (A-I w/o A-II) and (A-I w A-II) r-HDL were compared by fluorescence spectroscopy. Male sex and ulceration of the primary MCC were identified as independent unfavorable prognostic markers for the clinical outcome. Further studies are essential to predict a relationship between mineral density, atomic numbers, and mechanical stability. Treatment of choriocarcinoma cells with methotrexate (MTX) will induce a cell type intermediate between a cytotrophoblast and syncytiotrophoblast. Similar results were obtained with the injection of purified erythropoietin. We could not obtain conclusive data suggesting that the eosinophilic material was dental hard tissue because the eosinophilic material was not stained specifically by any methods. The production of cytokines by immunocompetent cells of intact mice was studied in various phases of the diurnal cycle.

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Overview of ethical issues perceived by allied health professionals in the workplace. Ca-VO2 correlated inversely with femoral blood flow, plasma renin activity, plasma aldosterone concentration, and degree of shunting measured by microspheres. Taken together, our study indicates that in addition to regulating DNA repair fidelity during transposition, DNA-PK also affects transposition efficiency by promoting paired-end complex formation. The design and contours of the interim crown are designed by the computer software to be identical to the contours of the tentatively designed definitive prosthesis. We performed a retrospective chart review of 256 Malone antegrade continence enema procedures. Rapid capillary filling via ion-water interactions over the nanoscale. Impact of routine coronary catheterization in low extremity artery disease undergoing percutaneous transluminal angioplasty: study protocol for a multi-center randomized controlled trial. Although it has been speculated that O-GlcNAcylation is associated with glucose metabolism, its exact role in whole body glucose metabolism has not been fully elucidated. This study aimed to biomechanically analyze known fracture patterns and to study how they relate to fracture mechanisms.

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This syndicate included eight units in public general hospitals, five in stand-alone public psychiatric hospitals and five in private psychiatric hospitals. A systematic search of electronic databases yielded 15 publications from 1998 to March 2014 that met the inclusion criteria. Cloning and functional characterization of a representative set of these enzymes confirmed the capacity of each genus to produce ent-kaurene. Most chemotherapy drugs act nonspecifically and damage both cancer and healthy cells causing various side effects. We aimed to assess the effectiveness of any type of impregnation (antibiotic or heparin) compared with standard central venous catheters to prevent bloodstream infections in children needing intensive care. In 50 intact white rats at the age of 6, 15, 23 and 30 months synapsoarchitectonics of the celiac plexus nodes was studied by an electron microscopy method. Seventeen placentae from second trimester abortions induced by the injection of extra-amniotic prostaglandin have been examined. In rice roots, although auxin transport and responses were required for both gravitropism and hydrotropism, the root cap was involved in the auxin regulation of gravitropism but not hydrotropism.

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Researchers responsible for data gathering were blinded for this study. Sanguinarine (Sang) - a benzophenanthridine alkaloid extracted from Sanguinaria canadensis - exhibits antioxidant, anti-inflammatory, proapoptotic and growth inhibitory activities on tumor cells of various cancer types as established by in vivo and in vitro studies. capreoli from infected roe deer (Capreolus capreolus), the natural host of B. The influence of a mono- and biphasic oral contraceptives on colpitis of diverse etiology. Electronic survey of the RRP Task Force of the American Society of Pediatric Otolaryngology, American Broncho-Esophagological Association, and physicians known to the authors to have used systemic bevacizumab for RRP. The proliferative state of the CFU-S was not changed significantly by the presence of the leukemia cells as determined by using 5-fluorouracil as a proliferative probe. The aim of this study was to evaluate the level of exposure of petrol attendants to petrol VOCs and also to determine their effect on DNA damage and repair in lymphocytes of African petrol attendants. With the patient in a prone position, we made a horizontal skin incision at the level of C2 and unilaterally exposed the right side of the C1 and C2 laminae. Diagnostic value of exercise-induced S-T segment depression in patients with right bundle branch block. Unexpectedly, both Collembola and earthworms predominantly affected the mobilization of N from soil organic matter, and by altering the distribution of litter earthworms reduced infestation of crops by aphids via reducing plant capture of litter N, in particular if the litter was concentrated deeper in soil.

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