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Leukeran (Chlorambucil)
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Leukeran

Leukeran is used treat a certain type of chronic lymphocytic leukemia. Leukeran is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

Other names for this medication:
Chloramax, Chlorambucil

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Also known as: Chlorambucil

Description

You should take Leukeran according to your doctor’s or healthcare provider’s instructions.

When to take

Different dosages of Leukeran may be prescribed depending on the condition that’s being treated. Usually, Leukeran is taken once daily for a few weeks. But this isn’t always the case. Sometimes, Leukeran is taken only once every two weeks or once monthly.

For more information about dosing schedules for Leukeran, see the section “Leukeran dosage” above. And talk with your doctor about how often you’ll need to take this medication during treatment.

To help make sure that you don’t miss a dose of Leukeran, try setting a reminder on your phone. A medication timer may be useful, too.

Can Leukeran be crushed, split, or chewed?

Leukeran shouldn’t be crushed, split, or chewed.

This is because Leukeran is a chemotherapy drug. And these drugs are generally considered harmful to handle.

Talk with your doctor or pharmacist about how to safely handle Leukeran while you’re taking it. And if you have trouble swallowing Leukeran tablets, talk with your doctor or pharmacist about safe ways to make doing so easier for you.

Dosage

The Leukeran dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Leukeran to treat
  • your weight
  • how often you take Leukeran
  • other medical conditions you may have
  • results from certain lab tests you’ll have while you’re taking Leukeran
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Leukeran is available as 2-mg tablets that are taken by mouth.

Dosage for chronic lymphocytic leukemia

The usual dose of Leukeran for chronic lymphocytic leukemia (CLL) is 0.1 mg of drug per kilogram of body weight (mg/kg). This dose is typically taken once daily.

Intermittent dosing vs. daily dosing for CLL

In some cases, doctors may prescribe intermittent dosing for Leukeran for CLL rather than daily dosing. With intermittent dosing, the drug is taken once every 2 weeks or once each month. And in these cases, the dose of Leukeran given may be different than the typical dose given.

For some people with CLL, intermittent Leukeran dosing works better than daily dosing. In addition, certain side effects, such as changes in blood cell levels, may be reduced with intermittent dosing.

Dosage for lymphoma

Below we describe the typical doses of Leukeran for certain types of lymphoma that Leukeran is approved to treat.

Dosage for certain types of non-Hodgkin lymphoma (NHL), such as follicular lymphoma (FL)

The usual dose of Leukeran to treat certain types of NHL, such as FL, is 0.1 mg of drug per kg of body weight (mg/kg). This dose is typically taken once each day.

Dosage for Hodgkin lymphoma (HL)

The usual dose of Leukeran to treat HL is 0.2 mg/kg. This dose is typically taken once each day.

Pediatric dosage

The safety and effectiveness of Leukeran hasn’t been studied in children. But in some cases, Leukeran is prescribed for children with certain conditions. (Keep in mind that this is an off-label use of the drug. With off-label use, a drug that’s approved for certain uses is given or being studied for a different use.)

Because the Leukeran hasn’t been approved for use in children, the drug’s manufacturer hasn’t recommended a typical dosage for children.

If you have questions about pediatric dosage for Leukeran, talk with your child’s doctor. They can recommend a dosage of Leukeran for your child’s needs.

What if I miss a dose?

If you miss a dose of Leukeran, call your doctor’s office. You doctor or their medical staff can help you determine when you should take your next dose of the drug. And they’ll recommend whether you should take a dose to make up for the missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

It depends. The number of Leukeran treatment cycles you’ll receive may depend on several factors. These include the type and severity of your cancer, as well as your medical history.

In one study of people with CLL, the people took chlorambucil (the active drug in Leukeran) every 28 days for up to 12 months. And a review of studies found that, across several clinical studies of chlorambucil for CLL treatment, people took between 6 and 12 treatment cycles of the drug.

Leukeran is usually given every day for 3 to 6 weeks. But your doctor may recommend that you take it once every 2 weeks or once each month.

If you have questions about how long you’ll need to take Leukeran, talk with your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation, fast heartbeats, skin rash, bruising, bleeding gums, nosebleeds, trouble breathing, or signs of infection (fever, chills, weakness).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Leukeran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not be treated with Leukeran if you are allergic to it, or if you have received this medicine in the past without successful treatment of your condition.

You may not be able to receive Leukeran if you've ever had an allergic reaction to another cancer drug such as bendamustine, busulfan, carmustine, dacarbazine, ifosfamide, lomustine, mechlorethamine, melphalan, streptozocin, or temozolomide.

Tell your doctor if you have ever had:

kidney disease; liver disease; a seizure; a head injury or brain tumor; or if you have received radiation or chemotherapy within the past 4 weeks.

Taking Leukeran may increase your risk of developing other types of cancer. Talk to your doctor about your specific risk.

Do not use Leukeran if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using Leukeran.

This medicine may affect fertility (ability to have children) in both men and women. However, women should still use birth control to prevent pregnancy because Leukeran can harm an unborn baby.

You should not breastfeed while using this medicine.

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