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Micardis

Micardis is used alone or in combination with other medications to treat high blood pressure. Micardis is also used to decrease the chance of heart attack, stroke, or death in people 55 years of age or older who are at high risk for cardiovascular disease.

Other names for this medication:
Deprevex, Domidis, Gliosartan, Kinzal, Kinzalkomb, Kinzalmono, Kinzalplus, Mitosan, Predxal, Pritorplus, Saitan, Samertan, Telma, Telmisartan, Telmisartanum, Telpres, Telsan, Twynsta

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Also known as: Telmisartan

Description

Micardis is a member of a family of drugs called angiotensin receptor blockers (ARBs), which includes losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), and candesartan (Atacand). ARBs block the ability of the chemical angiotensin II to constrict or squeeze arteries and veins. As a result, the arteries and veins enlarge and blood pressure falls. The reduced pressure in the arteries also makes it easier for the heart to pump blood. Generic name of Micardis is Telmisartan. Micardis is also known as Telmisartan, Pritor, Kinzal, Telma, Telday, Teleact D. Brand name of Micardis is Micardis.

Dosage

Usual Adult Dose for Hypertension:

Initial dose: 40 mg orally once a day Maintenance dose: 40 to 80 mg orally once a day Comments: Most of the antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose.

Usual Adult Dose for Cardiovascular Risk Reduction:

80 mg orally once a day Comments: It is unknown whether doses lower than 80 mg are effective in reducing the risk of cardiovascular morbidity and mortality. -When initiating this drug for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of other medications that lower blood pressure. Use: Reduction of risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years or older at high risk of developing major cardiovascular events who are unable to take angiotensin-converting enzyme (ACE) inhibitors. High risk for cardiovascular events can be evidenced by a history of coronary artery disease, peripheral arterial disease, stroke, transient ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin dependent) with evidence of end-organ damage.

Detailed Micardis dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Tablets should not be removed from the blisters until right before use. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Micardis are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Micardis if you are allergic to Micardis components. Be very careful with Micardis if you're pregnant or you plan to have a baby, or you are a nursing mother. This drug can cause serious fetal harm (possibly death) if used during the last six months of pregnancy. Be careful with Micardis if you have kidney disease, liver disease, high blood levels of potassium, heart problems, severe dehydration (and loss of electrolytes such as sodium), diabetes (poorly controlled), any allergies (especially to ACE inhibitors such as captopril, lisinopril). To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Use Micardis with great care in case you want to undergo an operation (dental or any other). Be careful with Micardis if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Micardis if you have allergies to medicines, foods, or other substances. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Elderly patients should be careful with Micardis. They may be more sensitive to its effects. Avoid alcohol. Avoid machine driving. Do not stop taking Micardis suddenly.

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Primary outcome was the proportion of subsequent hospitalizations or prescribed trials of bronchodilator/corticosteroid therapy for dyspnea by day 6 in the groups. Stable centromere positioning in diverse sequence contexts of complex and satellite centromeres of maize and wild relatives. Conditional logistic regression modeling was performed to establish the association of jail time with the development of tuberculosis. Application of a new palpometer for intraoral mechanical pain sensitivity assessment. For successful drug development, it is essential to determine pharmacological parameters (i.e., affinity, potency, and efficacy) and the mode of action of potential drugs during early stages of research in order to predict the biological effect of chemokine receptor targeting drugs in the clinic. Community structure traits respond only once ecological damage has already been done and do not provide early warning signals. Cerebral hemorrhage associated with the use of phenylpropanolamine. Diatraea saccharalis, the main pest of sugarcane, has been controlled by Cotesia flavipes. Lifestyle intervention can improve the MetS-related pro-thrombotic state. Intravenous challenge was carried out with four Belgian NIBV-isolates and with the Italian NIBV-strain AZ23.74.

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In this investigation we compared the diagnostic performance of unenhanced helical CT, oral contrast-enhanced CT cholangiography, and MR cholangiography for the diagnosis of choledocholithiasis. Therefore we developed a course model by which the managing of surgical interventions is possible. A higher level of frustration was perceived during the following clinical situations: lack of respect by student-athletes and coaching staffs, the demands of the clinical experience, inability of ATSs to perform or remember skills, and ATSs not having the opportunity to apply their skills daily. These fiducial dots provide coincident and clear 3D data points that when scanned into a digital impression allow superimposition of the 3D models. Surgical clips of different sizes were inserted inside the breast. This paper describes the development of a PCR-based assay that is capable of detecting all ten species of Eimeria, including OTUs X, Y, and Z in field samples. Four had remaining instability following a Putti-Platt procedure, with a mean retroversion angle of 18 degrees. The inspiratory increase in the inflow velocity was observed in mild cardiac tamponade, but not in severe one. Secretory leukocyte protease inhibitor (SLPI), an anti-inflammatory mediator of mucosal immunity, inhibits human immunodeficiency virus (HIV) and herpes simplex virus (HSV) in cell culture. It is important to stress, that chronic pyogenic otitis media which first occurred as the patient was over fifty should arouse suspicion of neoplastic disease.

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The groups did not differ on the two primary outcomes, time to first drink and time to relapse to heavy drinking, or on secondary treatment outcomes. The location and extent were more easily comprehended on the displays compared to the slice-by-slice presentations of tomograms. This research was funded in part by a National Research Service Award (T3HP10028-14-01). Deep neuromuscular blockade improves surgical conditions during low-pressure pneumoperitoneum laparoscopic donor nephrectomy. To describe patient desire and reasons for specialist referrals in a gatekeeper-model managed care plan. A noninvasive, nonheated oxygen electrode was used to measure the tissue surface transmucosal oxygen tension directly on the attached gingiva.

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PTX loaded microspheres were prepared by o/w emulsion solvent evaporation technique using the blends of poly(lactic-co-glycolic acid) (PLGA) 75/25, polycaprolactone 14,000 and polycaprolactone 80,000. Comparison of Urologic Complications Between Ureteroneocystostomy and Ureteroureterostomy in Renal Transplant: A Meta-Analysis. Factors which affect the in vitro inhibition of human plasma cholinesterase. Genetic variation in the GSTM3 promoter confer risk and prognosis of renal cell carcinoma by reducing gene expression. If this process takes place in the lung, ARDS may develop and if other organs, i.e the liver and the kidneys, are involved, MOF may be the result. When the heart remodels from a more or less straight into a c-shaped tube the sharp curvature, in combination with the small vessel dimensions and high relative viscosity, directs the highest shear stress to the inner curvature of this pump. To investigate the regulation of mesangial cell proliferation in vivo we have studied the mesangioproliferative glomerulonephritis that is induced by injection of antibody directed against the Thy 1.1 antigen on the mesangial cell surface in rats. Prevalence and patterns of anti-nuclear antibodies in Korean children with juvenile idiopathic arthritis according to ILAR criteria. We have explored the shortening of the cycle interval as a way to increase the DI of DDP. The human derived mesenchymal stem cells (MSCs) were obtained from umbilical cord (UC), bone marrow (BM), and adipose tissue (AD), respectively.

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Despite residual disease after surgery, bone marrow recovery occurred without administration of bone marrow stimulants and serum estradiol accurately predicted tumor recurrence. Intramuscular venous malformations have been previously described as intramuscular hemangiomas, and various therapies have been applied for their treatment. Ezetimibe plus pravastatin significantly improved FMV in patients with SLE, decreasing ED and the lipid profile. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process. A 17-year-old apprentice affected with siderosis bulbi and lentis of his right eye, was examined by biomicroscopy, ultrasonography and x-rays without evidence of an i.o. Comparison in women versus men of composition of atherosclerotic plaques in native coronary arteries and in saphenous veins used as aortocoronary conduits. To evaluate the response to second vaccination series among post-booster sero-negative children who had previously received compulsory HBV vaccination. Its anticlastogenic potential was therefore evaluated with a micronucleus assay.

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Influence of preoperative donor tissue characteristics on graft dislocation rate after Descemet stripping automated endothelial keratoplasty. The elastic modulus of the collagen gels was decreased through the addition of poly(ethylene glycol) during the gel preparation. Bile-stained vomiting starts within the first days of life and is followed by the clinical signs of high bowel obstruction and peritonitis. The effects of nitrogen nutrition on photosynthetic characteristics and on the limited factors to photosynthesis are not identical under different water status. In this work, a suitable nitrogen source was screened out for the high and cost-effective production of gamma-PGA in Bacillus subtilis ZJU-7. During follow-up of up to eight years (679,485 person-years) that was 97 percent complete, we documented 552 cases of major coronary disease (437 nonfatal myocardial infarctions and 115 deaths due to coronary disease). Trends in Substance Use Among 6th- to 10th-Grade Students From 1998 to 2010: Findings From a National Probability Study.

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Smoking students should be more strongly involved in the implementation process, e.g., by supplemental cessation programmes. This review re-emphasizes the suggestion about the dual function of these two secreted mycobacterial proteins, viz., they have both T-cell activation and macrophage deactivation functions. Adverse health effects as well as fatalities have been implicated with its use. The effects of daily brief periods of low intensity vibration (LIV) on neuromuscular functions and behavioral correlates were assessed in mice. Luciferase assays were conducted to evaluate the interaction between NF-E2-related factor-2 (Nrf-2), the antioxidant response element (ARE), and the promoter region of the HO-1 gene and subsequent gene expression.

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Morphometric analysis showed that spinal cord inflammatory lesions were significantly smaller and fewer in IGF-I-treated rats. Terramycin in serum and urine after ingestion of terramycin base. Electrical stimulation lasting 30-40 days resulted in no further enhancement of GLUT-4 protein content while citrate synthase activity continued to increase. Renal hepatitis C in the absence of detectable serum or hepatic virus. This test seems to be useful for estimation of phenolic and indolic compounds in urine of patients with increased production of compounds of this nature, particularly in some tumors. A retrospective chart and radiographic review was performed to identify the age, the sex, the treatment method, complications, the fracture type, and articular displacement. Walking ability and endurance seem to improve after participation in an intensive summer sports programs. Reverse transcriptase sequences from ART-naive individuals who commenced efavirenz (EFV) or nevirapine (NVP) with at least two nucleos(t)ide reverse transcriptase inhibitors (NRTIs) without major drug resistance mutations were analyzed. Searches for single virulence genes can now be performed on a genomewide scale by a variety of computer and genetic techniques. The ATP-dependent translocation of phosphatidylserine to the mitochondria is a process that is restricted to the autologous organelle.

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The variables related to the clinical and functional status were reliable predictors for length of stay, for discharge destination, and for re-hospitalisation among older patients admitted to ten geriatric units in Italy. Gene mutation, gene expression in Escherichia coli and analysis of carotenoid products were used to investigate the functions of these candidates. Prognostic factors and therapeutic decisions in axillary node-negative breast cancer. These results indicate that mutant genes in plasmids can be repaired by TRC-induced recombination. Factors associated with maternal mortality were obtained from death certificates, replies to questionnaires, medical records, and autopsy reports. From a South Korean national health insurance sample cohort database for 2002-2013, we matched parkinsonism cases (defined by diagnosis codes for parkinsonism/Parkinson disease) and Parkinson disease cases (patients who had records for both Parkinson disease diagnosis and anti-Parkinson disease drug prescriptions) with controls. The propeptides of the vitamin K-dependent proteins contain a gamma-carboxylation recognition site that is required for gamma-glutamyl carboxylation. Primary Recurrence in the Lung is Related to Favorable Prognosis in Patients with Pancreatic Cancer and Postoperative Recurrence.

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The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence. All three AFP enhancers continue to be active in the adult liver, where EI and EII exhibit high levels of activity in pericentral hepatocytes with a gradual motrin dose max reduction in activity in a pericentral-periportal direction. Promoting the proliferation and differentiation of OPCs into mature OLs that can myelinate axons is the key to stimulate remyelination. From the biological point of view, the clonal selection hypothesis represents the most accepted mechanism to explain how mutations increasing the affinity for target antigens are introduced and selected in antibody molecules. Further investigation revealed a single reactive cysteine in the annexin II tail domain. Plants require a complex balance of mineral nutrients to reproduce successfully. Effectful treatment leads to an increase associated with a wider range between maximal and minimal viscosity.

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In the absence of complete data on the frequency of particular diseases caused by this virus in our population, tests for human parvovirus B19 are strongly recommended. Prevalence of arthritis according to age, sex and socioeconomic status in six low and middle income countries: analysis of data from the World Health Organization study on global AGEing and adult health (SAGE) Wave 1. Proximal femoral osteosarcoma: Diagnostic challenges translate into delayed and inappropriate management. Effects of functional endoscopic sinus surgery on maxillary sinus mucosa. Spectral properties of the Preisach hysteresis model with random input. Urinary polyamines were measured by a fluorometric thin-layer chromatographic technique in samples collected daily throughout a single menstrual cycle by each of 13 healthy women. Pre-admission CHA2DS2-VASc score and outcome of patients with acute cerebrovascular events.

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Mitochondria are dynamic organelles present in virtually all human cells that are needed for a multitude of cellular functions, including energy production, control of cell apoptosis and numerous biochemical catabolic and synthetic pathways that are critical for cellular health. Intratympanic inoculation of 0.2 ml physiologic saline solution containing 10(4) plaque-forming units (PFU)/ml of influenza A suspension or 100 ng/ml lipopolysaccharide failed to induce either middle ear effusions or mucociliary pathologies in the tubotympanum. AGN was added to one aliquot and nothing was added to the control aliquot. Stool specimens of all these subjects were inoculated on cycloserine cefoxitin fructose agar and incubated anaerobically to isolate C. The presence of a number of conditioned-pathogenic enterobacteria (Klebsiella, Citrobacter, Enterobacter) in patients with intestinal dysbacteriosis, and also their detection in derangement of normal intestinal biocenosis in patients with chronic intestinal disturbances with clinical manifestations of this condition, even in the absence of known bacteriological indications of dysbacteriosis was revealed. This norethindrone 5 mg dosage paper is a report on the successful treatment of palmar hyperhidrosis using a minimally invasive posterior technique and describes the surgical approach and outcomes in 2 patients who have been treated in this manner. This is becoming a much debated issue, and the immunohistochemical detection of Programmed Death Ligand 1 (PD-L1), the ligand for the inhibitory Programmed Death receptor 1 (PD-1) checkpoint, is one possible biomarker. Posterior scleral reinforcement combined with vitrectomy for myopic foveoschisis. The combined use of generic (LCA) and spatially referenced data offers new opportunities for comprehensively analysing the environmental impact of novel technologies.

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This 630-bp fragment was present among progeny of only 4 of these 10 plants after selfing, i.e. A particularly high risk of medical errors is seen in emergency settings, unexpected change in procedure, or in patients with a high body mass index. Seven patients lacked follow-up data, leaving 51 patients-17 patients with DeBakey IIIa aortic dissection and 34 patients with DeBakey IIIa aortic dissection IIIb-for inclusion in the study. Moreover, YC-1 triggered mitochondria-mediated and caspase-dependent pathways. GPR37 has been shown to exert effects on oligodendrocyte differentiation and myelination during development, but the molecular basis of these actions is incompletely understood and moreover nothing is known about the potential role(s) of this receptor under demyelinating conditions.

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