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Nolvadex

Nolvadex has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Nolvadex attaches to the hormone receptors in the cancer cell, blocking estrogen from attaching to the receptors.

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Also known as: Tamoxifen

Description

Tamoxifen is used to treat certain types of breast cancer (eg, estrogen receptor-positive breast cancer that has spread to other parts of the body [metastatic], early stage estrogen receptor-positive breast cancer after surgery and radiation treatment). It is also used to reduce the risk of invasive breast cancer in adult women with ductal carcinoma in situ (DCIS) after breast surgery and radiation treatment.

Tamoxifen is also used to reduce the risk for breast cancer in women with a high chance of getting it. The following are risk factors that may increase your risk of developing breast cancer:

If you have close family members (mother, sister, or daughter) with breast cancer. If you have ever had a breast biopsy or if high-risk changes in your breast(s) have been found from a breast biopsy. If you have never been pregnant or if your first pregnancy occurred at a late age. If your first menstrual period occurred at an early age.

Female hormones called estrogen, that occur naturally in the body can increase the growth of some breast cancers. Tamoxifen works by blocking the effects of estrogen in the body.

This medicine is available only with your doctor's prescription.

Dosage

The dosage of Nolvadex depends on the type of your disease and health state. Take Nolvadex once or twice a day with or without food. Take Nolvadex tablets orally at the same time every day with water. If you want to achieve most effective results do not stop taking Nolvadex suddenly.

Overdose

If you overdose Nolvadex and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Nolvadex overdosage: uncontrolled body shaking, unsteadiness, problems with walking, convulsions, lightheadedness, exaggerated reflexes, problems with breathing, tremor.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not store the oral liquid in the refrigerator or freezer. Throw away any unused liquid after 3 months of first opening the bottle.

Detailed Nolvadex dosage information

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The most common side effects associated with Nolvadex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Nolvadex if you are allergic to its components. Do not take Nolvadex if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not take Nolvadex if you have a history of leg or lung blood clots. Do not take Nolvadex if you are taking anticoagulants, anastrozole. Be very careful with Nolvadex if you suffer from or have a history of vision problems, diabetes, heart attack, stroke, high blood levels of cholesterol, high blood pressure. Be careful with Nolvadex if you are taking phenobarbital; aminoglutethimide (such as Cytadren); cancer chemotherapy medicines (cyclophosphamide (such as Neosar, Cytoxan), letrozole (such as Femara); bromocriptine (such as Parlodel); cytotoxic cancer medicines; aromatase inhibitors; fluorouracil or mitomycin C, medroxyprogesterone (such as Provera, in Prempro Depo-Provera); rifampin (such as Rimactane, Rifadin). Avoid people who have infections or colds. Do not take Nolvadex if you are taking birth-control medications. Avoid consuming alcohol and smoking cigarettes. Do not drive or operate machinery while taking Nolvadex. Do not stop taking Nolvadex suddenly.

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Confirming in vitro results, high-dose (80-mg) simvastatin improved neutrophil migratory accuracy without impeding other neutrophil functions in a double-blind randomized clinical trial in healthy elders. The common wild fig, Ficus thonningii, is extensively used in African ethnomedicine for treating a number of disease conditions which include diarrhoea, urinary tract infections, diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. Medical records of 303 SCI patients who referred to the urodynamic unit of a rehabilitation hospital between 1996 and 2003 were retrospectively reviewed. Subsequently, duodenal biopsies showed evidence for Strongyloides, presumably acquired 20 years ago when the patient was residing in Brazil. Transactivation assays showed that TOPP1 and AtI-2 negatively regulated the SnRK2.2/3/6-mediated activation of the ABA responsive reporter gene RD29B, supporting a negative role of TOPP1 and AtI-2 in ABA signaling.

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Chronic treatment with amineptine induces downregulation of dopamine D2, beta- and alpha 2-adrenergic receptors. Evoked responses of systolic and diastolic blood pressure and heart rate at steady state during the noradrenaline infusion. The presence of a carboxylate substituent resulted in prevention of binding, which was reversed by esterification of the group. Km values determined with recombinant NAT1 and NAT2 proteins expressed in Escherichia coli were 1.5 mM and approximately 15 mM, respectively. Although use of an ICD was inversely related to death, no differences in overall survival were seen after those patients were excluded.

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Dose-response study of inhaled salmeterol in asthmatic patients with 24-hour spirometry and Holter monitoring. Examining Endothelial Function and Platelet Reactivity in Patients with Depression before and after SSRI Therapy. Validity of hair cadmium in detecting chronic cadmium exposure in general populations. Our study shows that when simvastatin is administered at its MTD, only low micro-molar concentrations are achieved in plasma and PBMCs, which is consistent with the results observed in previous studies with lovastatin, but far lower than the concentrations required for anticancer effects in vitro. Central gray cells within this termination zone project bilaterally to the abducens nuclei. The advent of targeted biological chemotherapeutic agents and the development of loco-regional therapies (chemoembolization, thermal ablation, arterial infusion chemotherapy) contribute to extend favorable results. In this study, we found that SAA untreated patients had lower TIM-3 expression on NK cells and CD56dim NK subsets compared with normal controls, and were correlated with the severity of pancytopenia of SAA.

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High-mobility group box prometrium 200 mg side effects 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. An experimental case of urinary calculus in a Holstein-Friesian steer. Such decisions should be made at the political level, the more so since they affect individual entitlements to care under health insurance legislation. Three patients developed severe, incapacitating diarrhea after antibiotic administration. We demonstrate the first direct images of a suspended 0D/2D heterostructure that incorporates C60 molecules between two graphene layers in a buckyball sandwich structure. Occupational exposure to free silica is widespread in several economic sectors and is well known to cause silicosis. For patients with at least one medication error all contacts with hospital or primary care within 3 months after discharge were identified. Conditions of this portion of the respiratory tract are relatively uncommon. The feedback parameters of the model may differ between individuals and only in some cases do they take values that make weight gain self-promoting.

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