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Pacyl (Alprazolam)
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Pacyl

Pacyl is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Pacyl, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Pacyl is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aldep, Alpanol, Alprasan, Alprasert, Alpron, Alprop, Alprowon, Alprozam, Alrif, Alzoax, Alzopax, Alzoset, Ambusyn, Andep, Anxicalm, Axizox, Azoslip, Balzam, Cardilax, Depser, Diprex, Endep, Mebaspa, Mediprex, Oclam, Pralam, Restyl, Rezolam, Richpram, Romipraz, Tenlax, Tenolam, Trazopin, Trika, Wycalm, Xylonite, Zenax, Ziety, Zolin, Zolorest, Zopral

Similar Products:
Ceclor, Sovaldi, Casodex, Effexor, Antivert, Adalat, Zyprexa, Ultram, Kemadrin, Theolair, Zydero, Trimethoprim, Telidin, Lopressor, Norocin,

Also known as: Alprazolam

Description

Pacyl (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

Pacyl is used to treat anxiety disorders and anxiety caused by depression.

Pacyl is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase Pacyl on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.

Dosage

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

Measure the liquid form of Pacyl with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not swallow the orally disintegrating tablets whole. Allow it to dissolve in your mouth without chewing.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

You may have seizures or withdrawal symptoms when you stop using Pacyl. Ask your doctor how to avoid withdrawal symptoms when you stop using Pacyl.

Keep track of the amount of medicine used from each new bottle. Pacyl is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Overdose

If you have been prescribed Pacyl for medical reasons, the best way to avoid a Pacyl overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Pacyl consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Pacyl are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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We report the case of a 56-year-old patient who presented with serous macular detachment caused by optic disc pit and responsible for a deterioration of visual acuity. A case of a breast tumor which showed the appearance of invasive ductal carcinoma and chondrosarcoma is reported. As an application of the above chiral building blocks to the synthesis of biologically active natural product, we demonstrated the diastereodivergent synthesis of the 3-piperidinol alkaloids cassine, spectaline, prosafrinine, iso-6-cassine, prosophylline, prosopinine, and also established the flexible route to the 5,8-disubstituted indolizidine or 1,4-disubstituted quinolizidine type of Dendrobates alkaloids. Since a virus scintigraphy is not realistic in a hospital setting, we have developed an approach using 99mTc-DTPA (diethylene triamino pentaacetic acid) that could be used to predict the virus deposition. Our results show that (i) yxbA encodes D-Asp ligase responsible for incorporation of D-Asp in the PG crossbridge, and we therefore renamed it as aslA, (ii) it is an essential gene, which makes its product a potential target for specific antimicrobials, (iii) the absence of D-Asp may be complemented by L-Ser-L-Ala or L-Ala-L-Ala in the L. Finally, we deleted the genes encoding PhdB and PhdG and demonstrated that both proteins are required for efficient chemotaxis. These results indicate that combined treatment with pidotimod and RGAP has an immunostimulatory effect in a synergistic manner on antibody response to challenge with LPS and SRBC without toxic changes. There were true pulmonary arteries and three major aortopulmonary collaterals.

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In this study we hypothesized that EGF may play a role in the pathophysiology of autism and examined serum EGF levels in children with autism. Fifty nine candidate olfactory receptor (Or) genes have recently been identified in Drosophila melanogaster, one of which is Or43a. Part of the proBNP molecule (amino acid residues 61-76) located near the cleavage site was inaccessible to specific MAbs because of the presence of O-glycans, whereas the same region in NT-proBNP was completely accessible. Cadaveric response was found to be similar to that of the relaxed volunteer. The value of the method with regard to staging and diagnosis is discussed. However, the effects of Fusheng powder on anti-adhesion are of great importance in clinical cardiovascular and cerebral vascular diseases. fMRI binary detection of brain activated regions with graph-cuts. Second, a review of the research and clinical situation is developed for CaP materials already used as drug delivery systems. Aspects of neuroleptic depot therapy with special consideration of clinical experiences with the preoral depot preparation Penfluridol (R 16 341-Jannsen).

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Proliferation and differentiation of neural stem cells after cerebral infarction: an experimental study of adult rats. In the CAPSID group, a slow, gradual balloon inflation was performed by a personal computer. CFs were highest for those soils containing the lowest concentrations of Mg, Ca and Ba, and approached a saturation value at higher soil concentrations. The structures were examined as a function of the charge density of the dendrimer expressed by its degree of protonation (dp) and the molar ratio of the amine groups of dendrimer to the phosphate groups of DNA (N/P). The only curative option for patients with EMS at this time appears to be bone marrow or stem cell transplantation. The content of time in everyday life can be described as follows: fragmented time, vacuous time, and uninterrupted time.

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From the results it has been suggested that the selectivity of the fiber-packed column could be tuned by selecting different coating materials, indicating the promising possibility for a novel usage of fine fibrous polymers as the support material that can be combined with newly synthesized coating materials specially designed for particular separations. The authors performed tests for serum albumin, prealbumin, and amino acid profiles on 18 consecutive hospital patients with wounds and 7 patients without wounds. These raise the possibility of a stroke and are common in clinical practice. One of two products was consistently presented in the vicinity of the humorous cartoons, whereas the other product was consistently presented in the vicinity of the nonhumorous cartoons. In this paper we study and implement different adaptive methods for predicting the future heart motion using Kalman filtering. Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families.

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Although these muscular dystrophies arise from mutation of a single gene that is expressed primarily in muscle, the resulting pathology is complex and multisystemic, which shows a broader disruption of homeostasis than would be predicted by deletion of a single-gene product. Serial propagation of porcine group C rotavirus (pararotavirus) in primary porcine kidney cell cultures. At large, physicians practicing in tertiary centers adhere to the AUC when subjecting patients with non-acute coronary syndrome to revascularization. Less-abundant phylotypes include several minor members from other candidate divisions and one phylotype that was an outlier of candidate division OP3. We quantified global methylcytosine levels in PBMCs from 20 patients with vitiligo and 20 healthy controls. It protects the stability of the bone and open-lying delicate structures in patients with infected osteosynthesis of the ankle and angiopathy and offers an easy, safe, and successful treatment path with a short inpatient time. The technique builds a reduced set of relevant genes (FP, Fuzzy Pattern) able to summarize and represent each underlying class (pathology). The loss of I-A and the re-expression after phagocytosis were both reflected in the stimulatory capacity of these macrophages in the mixed leukocyte reaction. In pesticide-unexposed fish (control), the flow of the amino acid solution induced attraction, decreased sheltering, and increased horizontal displacements, burst swimming, buccal movements, and antagonistic interactions. The aim of this study was to measure retinal nerve fibre layer thickness (RNFLT) and its associated factors in a population-based setting.

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The latent origin of DNA replication, oriP, supports replication and stable maintenance of the EBV genome. Although the contents of yuanhuafine and yuanhuapine were low in the extract, the blood concentrations were extremely high. Several studies have demonstrated that bioactive autacoids generated from n-3 PUFA have direct anti-inflammatory and pro-resolution actions, and the structures of many of these endogenous mediators have been elucidated. The ratio was reversed for SN neurons (elevated Bcl-2 levels and transient reduction of Bax levels). Moreover, it was observed that bovine spermatozoa contain cytochrome c and apoptosis-inducing factor (AIF), two proteins usually released from the mitochondria during the apoptotic process. SIB 1893, a non-competitive antagonist of group I metabotropic glutamate receptor subtype 5, administered at doses ranging from 0.25 to 10 mg/kg, failed to influence pentetrazole-induced convulsions in mice. A rapid and reliable direct method for quantifying meat acylglycerides with monomode microwave irradiation. Under a new policy adopted in September 2008, Citizenship and Immigration (CIC) officers must now consider all evidence presented by an immigration applicant before making a decision of inadmissibility due to excessive demand on social services. The neurophysiological substrates underlying motor imagery are now well established.

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Crystal-storing histiocytosis complicating primary pulmonary marginal zone lymphoma of mucosa-associated lymphoid tissue. Considering the heterogeneity of haematological malignancies, the growing arsenal of compounds, allowing targeted therapy, e.g. Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation. Stakeholder perspectives need to be included as a core component of the fisheries management triangle (i.e. In this study we investigated the functional connectivity in 23 Mild TBI (mTBI) patients with and without memory complaints using resting state fMRI in the sub-acute stage of injury as well as a group of control participants. In this paper, we report the investigation of the reaction of adsorbed NH and N with styrene on Ag(110) using temperature-programmed reaction spectroscopy.

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Later DJ-1 was also found to be an infertility-related protein that was reduced in rat sperm treated with sperm toxicants that cause infertility in rats. A rare cause of syncope in a patient with diabetes mellitus--a case report. According to the modified index for developmental enamel defects, visual and tactile examinations of the entire primary dentition (buccal, lingual/palatal and incisal/occlusal) were performed. Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. This study aimed to investigate the underlying mechanism of GbE using HSC-T6 cells, a subline of hepatic stellate cells (HSC) as a model. Decreased bone density has been increasingly associated with hypercalciuria. Monocytes may be involved in destabilization of atherosclerotic plaques by production of matrix metalloproteinases (MMP). Cerebral bases of subliminal and supraliminal priming during reading. Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations. In situ hybridization analysis with mouse testis showed that the transcripts are expressed in germ line cells.

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A prospective cohort study was conducted in intensive care units of three tertiary hospitals in Porto Alegre, southern Brazil. Significantly more bulimic patients than controls stated they overate on sweets and avoided sweets. biloba leaves collected in November (after fruit harvest season), which revealed that the samples from different production areas exhibited regional disparity in different clusters in accordance with their various hydrophilic interaction chromatograms coupled with mass profiles. While resistance to older antibiotics is increasing, development of newer molecules has stalled. There was negligible release of the cytoplasmic enzyme, lactate dehydrogenase, under the same conditions. Correlations between sensor output and criterion measures were determined for pressure and temperature data. Moreover, blood oxygen level-dependent (BOLD) responses in the dorsolateral prefrontal cortex (DLPFC) and the anterior PFC during affective switching showed a linear decrease across controls, MDD and OCD.

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Allergic contact dermatitis from glyceryl monothioglycolate in hairdressers. The reverse PCR product was cloned and sequenced, and the acquired sequence was analyzed with bioinformatic methods. Those systems usually allow for different values for frame rate, pulse width or weighted frame averaging methods. Therefore, depending on the physiologic setting, ductal morphogenesis will be compromised both in the absence and overexpression of c-neu, thus explaining the paradox. Participation of protein kinase C in the activation of human neutrophils by phorbol ester.

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The aim of this meta-analysis was to assess the efficacy of the GVL in difficult tracheal intubations, comparing with that of Macintosh laryngoscopy. Two groups were identical to the cued-target groups from Experiment 1, with either fixed or variable escape locations. Statistical analysis of self-report measures identified a significant difference in professional identity, development of roles, and perception of enhanced opportunities for collaboration of dental technologists with the wider oral health professions in those undertaking the interprofessional curriculum. Percutaneous transhepatic therapy of bile duct stones and strictures. PKCepsilon depletion by RNAi or expression of a dominant negative kinase-dead PKCepsilon mutant potentiated the apoptotic response of PMA and sensitized LNCaP cells to the death receptor ligand TNFalpha. Since their use would lead to human and material damage orders of magnitude more extensive than anything ever known, and since the medical community would be impotent to respond in any meaningful way, all efforts must be directed to the prevention of nuclear war.

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When usual approaches for calculating sensitivity index involve the employment of Monte Carlo analysis, which is computationally expensive in the large-sampling paradigm, we develop two effective numerical approximate methods for quick SA evaluations based on the unscented transformation (UT) that utilize a deterministic sampling approach in place of random sampling to calculate posterior statistics. Transposon-mediated integration of the what type of medication is norvasc RP1 plasmid into chromosomes of methylotrophic bacteria. In six subjects in the piperacillin group, the mean t 1/2 beta of gentamicin when gentamicin was given alone was 53.9 h, and it was 37.7 h when gentamicin was given with piperacillin. Another mutation in a German family with primary torsion dystonia suggests that THAP1 mutations also cause dystonia in other ancestry groups. A clinically isolated syndrome: a challenging entity: multiple sclerosis or collagen tissue disorders: clues for differentiation. While trials show good levels of adherence to therapy, there often is room for improvement in the clinical setting.

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Medicago truncatula and Glomus intraradices gene expression in cortical cells harboring arbuscules in the arbuscular mycorrhizal symbiosis. Evaluate the progression of pain research by literature survey on Thai journals, since the beginning of TASP MATERIAL AND METHOD: Pain related original articles, except for the abstracts, proceedings, case reports, and review articles, published in eight Thai journals between 1990 and 2009 were searched. Irreversible electroporation (IRE) is a new technology for ablating aberrant tissue that utilizes pulsed electric fields (PEFs) to kill cells by destabilizing their plasma membrane. This result may be due to a true lack of effect, or it may be due to other factors, for example, the relatively young age of the cohort. A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for elavil drug interaction Scirrhous gastric cancer. The simplicity of the synthesis route coupled with the promising emission properties made the electrochemically synthesized ZnO nanowires a suitable candidate for high-current density applications. Mortality rates in the 3 months following spraying were significantly lower in sprayed camps although differences in clinical malaria incidence between sprayed and non-sprayed camps were not significant. The underlying molecular mechanisms are not completely understood. Pathological Relationship of Ditylenchus dipsaci and Fusarium oxysporum f.

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Hydrophobic dodecane tail (C12) modified 18 bp single-stranded DNA (ssDNA) probe was immobilized on BLMs. In contrast, boron in coal fly ash with better leaching characteristics appears as CaO- or MgO-trigonal BO(3) and tetragonal BO(4), and it is distributed only on the outer surface of each ash particle without showing any correlation with a particular element. It was concluded that genetic ecotoxicology could make significant contributions to the fields of environmental biomonitoring and ecological risk assessment, and that integration of genotoxicology and population genetic studies would be a definite advantage toward this end. The permanent role of Surgisis in aesthetic and reconstructive plastic surgery will be determined by its documented long-term performance. It is concluded that a GPIIb/IIIa antagonist promotes formation of platelet-leucocyte conjugates, which display P-selectin, TF and CD40L that appears to be associated with the adherent platelets. Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides.

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This study demonstrates the feasibility of expressing highly complex heterologous proteins in transgenic mice. To investigate the effect of central obesity on the severity and characteristics of age-related hearing impairment (ARHI), we recruited 690 adult subjects with normal or symmetrical sensorineural hearing loss (SNHL). In vivo analysis and DNase I footprinting indicated that the promoter specific for agaZ also requires activation by cAMP-CRP. During the past 10 years, considerable progress has been made in RSV vaccine development. Flow cytometric analysis revealed the expression of certain MSC stem cell markers including CD44, CD73, CD90 and CD105, respectively, although these markers were expressed at higher levels in the small-sized population. Ultrastructure of cerebral neurons during intravenous and inhalation anesthesia. NaCl and KCl significantly increased 2-thiobarbituric reactive substances (TBARS) and peroxide values. mori has a unique side branch in the kynurenine pathway, distinctly different from other insects. This descriptor allows handling combinatorial chemistry spaces as a whole instead of looking at subsets of enumerated compounds. The longitudinal AIDS Costs and Services Utilization Survey data are analyzed for illustration.

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Abstracts of the British Society of Gastroenterology Annual General Meeting. The incidence of incisional hernia at 6 months in the group sutured with normal tension was 10.0 per cent, compared with 5.5 per cent in those tightly sutured. Primary cutaneous zygomycosis due to Absidia corymbifera in a patient with cutaneous T cell lymphoma. mutans UA159 (parent strain) and AH333 (Deltaffh mutant) using microarray analysis. A contribution to the study of the movements of the tongue in animals, with special reference to the cat. Such transformational insights are key to furthering our understanding and in generating models, theories and processes that can be used to overcome recalcitrance of biomass for sustainable biofuel production. We measured SMAD4 protein expression using immunohistochemistry and SMAD4 copy number using quantitative real-time PCR.

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We report a patient with primary esophageal tuberculosis for whom the interferon gamma release assay facilitated a timely diagnosis. The SmartDiet mobile weight management application appears to contribute to weight loss in obese adults. Nephrostolithotomy has reduced transfusion rates and hospitalization costs and has markedly shortened convalescence periods compared with open surgery. Proteomics strategies to identify SUMO targets and acceptor sites: a survey of RNA-binding proteins SUMOylation. Vascularized temporoparietal fascial flap for the treatment of a traumatic cerebrospinal fluid fistula in the middle cranial fossa. This failure of P-deficient plants to respond to rising CO2 content above 200 micromol mol(-1) indicates that P status already imposes a widespread restriction in plant responses to increases in CO2 content from the pre-industrial level to current values. More and more mTOR inhibitors have been developed and demonstrated with great clinical potentials for multiple myeloma and other cancers.

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We reviewed the medical records of 139 patients meeting the Vancouver criteria for juvenile PsA. One group is exemplified by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine. Vancomycin monotherapy may not be adequate treatment for severe CA-MRSA infections. The results reveal 2 novel examples of targeting by localized translation, in LHCII subunit import and the targeting of the rubisco large subunit to the pyrenoid. These results indicate that intracellular and extracellular HSP70 have different roles in the regulation of cardiac remodelling and function in response to hypertension. To construct recombinant Lactococcus lactis strains exhibiting high beta-galactosidase activity in non-fusion way, and study their enzyme activities and enzyme secretion rates. Synthesis of highly functionalized macrocycles by the peripheral functionalization of macrocyclic diimines.

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Metanephric adenoma of the kidney: a clinicopathological and molecular study of two cases. In this article, we propose a reconstruction procedure that uses ubiquitously available multicore central processing unit to accelerate CS reconstruction from multiple channel data. Radiofrequency catheter ablation with large lesion technologies: what is the right formula?. Attitudes of obstetric and pediatric health care providers toward resuscitation of infants who are born at the leukeran margins of viability. Patterns of water use and exposure to trihalomethanes among children in Spain.

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Effect of different preparations of hormone therapy on sexual dysfunction in naturally postmenopausal women. Disease-specific utility instruments appeared to be more responsive than generic instruments. An 83-year-old woman presented with a predominantly left upper harga obat micardis 80 mg di apotik limb sensory ganglionopathy. We recently showed that ricin A chain (RTA) interacts with the P1 and P2 proteins of the ribosomal stalk to depurinate the SRL in yeast. The fibula free flap donor site has been associated with short-term donor site morbidity, most commonly delayed healing. Furthermore, allogeneic spermatogonia were also found to proliferate and differentiate into sperm in these grafts. Tissue necrosis caused by overly rapid expansion in the first patient was prevented by rapid, but more controlled, expansion in the second patient. American Academy of Pediatrics: Committee on Psychosocial Aspects of Child and Family Health and Committee on Adolescence. We also introduce the windowing effect for two multiscale methods.

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Intraoperative assessment of lymph node involvement in gastric carcinoma. We studied the association between plasma AT activity and clinical forms of MS. Skin conductance was recorded during a stress-test including acoustic, mental and physical stressors. The goals of this study were to determine: (1) 25OH vitamin D (25OHD) and calcium levels in patients with acromegaly and their association with insulin-like growth factor (IGF-1) and (2) whether somatostatin analog (SSA) therapy effects calcium and 25OHD levels. To explore the technique of rapid propagation for Phytolacca americana. Measurement and receptor modeling of atmospheric polycyclic aromatic hydrocarbons in urban Kaohsiung, Taiwan. To compare the efficacy of three electrical stimulation methods for spinal fusion based on the literature review.

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