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Symmetrel

Symmetrel is an antiviral medicine that blocks the actions of viruses in your body. Symmetrel is used to treat or prevent influenza A in adults and children. It may not be effective during every flu season because certain strains of the virus may be resistant to Symmetrel.

Other names for this medication:
Amantadine, Amantral, Amantrel, Comantrel, Neaman

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Also known as: Amantadine

Description

Amantadine is an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. Amantadine is also used to treat stiffness and shakiness caused by certain medicines that are used to treat nervous, mental, and emotional conditions.

Amantadine is also an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A). It may be given alone or together with flu shots. Amantadine will not work for colds, other types of flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain amantadine. It may not be specific to Symmetrel. Please read with care.

For patients taking amantadine for Parkinson's disease or movement problems (including dyskinesia) caused by certain medicines used to treat nervous, mental, and emotional conditions:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide or patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. Improvement in the symptoms of Parkinson's disease usually occurs in about 2 days. However, in some patients, this medicine must be taken for up to 2 weeks before the full benefit is seen.

For patients taking amantadine to prevent or treat flu infections:

Talk to your doctor about the possibility of getting a flu shot if you have not had one yet. This medicine is best taken before exposure or right away after exposure to people who have the flu. To help keep yourself from getting the flu, keep taking this medicine for the full time of treatment. Or if you already have the flu, continue taking this medicine for the full time of treatment even if you begin to feel better after a few days. This will help clear up your infection completely. If you stop taking this medicine too soon, your symptoms may return. This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your doctor. If you are using the oral liquid form of amantadine, use a marked measuring spoon, oral syringe, or medicine cup to measure each dose correctly. The average household teaspoon may not hold the right amount of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing. You may take this medicine with or without food.

Take Osmolex ER™ extended-release tablet in the morning. Swallow whole. Do not crush, open, or chew it.

Do not receive the nasal flu vaccine (live attenuated influenza vaccine) while taking this medicine.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor. For oral dosage forms (extended-release tablets): Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor. For oral dosage forms (liquid-filled capsules, syrup, and tablets): Adults—100 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Older adults—At first, 100 milligrams (mg) once a day as a single dose. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For the treatment or prevention of flu: For oral dosage forms (capsules, syrup, and tablets): Adults—200 milligrams (mg) or 4 teaspoonfuls once a day as a single dose. Older adults—100 milligrams (mg) once a day as a single dose. Children 9 to 12 years of age—100 milligrams (mg) or 2 teaspoonfuls 2 times a day. Children 1 to 9 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4.4 to 8.8 milligrams (mg) per kilogram (kg) of body weight per day. The dose is divided evenly and given 2 times a day. However, the dose is usually not more than 150 mg per day. Children younger than 1 year of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Symmetrel and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Symmetrel dosage information

Side effects

The most common side effects associated with Symmetrel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of Gocovri® and Osmolex ER™ in the pediatric population. Safety and efficacy have not been established.

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GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. In accordance with this, IFN-gamma mRNA was expressed inside tumor masses by infiltrating cells after IL-12 therapy irrespective of whether anti-IFN-gamma mAb was injected. The effect of chloroquine on the enzymatic hydrolysis of nucleic acids. There were multiple, anechoic structures noted within the pulmonary tissue in the left hemithorax, each measuring around 3 to 4 mm in diameter. Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain. In contrast, patients who had undergone spinal fusion who required a second procedure had significantly worse clinical and functional results, both in comparison to the patients who did not undergo fusion as well as to patients who had had fusion as a single procedure. Recent climatic drying leads to age-independent growth reductions of white spruce stands in western Canada. The highest levels of transgene expression were generally observed between 48 to 72 h following injection of the adenoviral vector. Repeated bouts of exercise in patients with anterior cruciate ligament reconstruction. The brain is able to sustain multiple bodily representations, and it is still unclear whether real body parts can be disembodied during the embodiment of fake or illusory body parts.

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Earlier researches demonstrated that ovarian hormones including estrogen and progesterone ameliorate cognitive function against various central nervous system disorders. Epidemiologic interviews conducted with both patients indicated common exposure at a community college, including one patient specifically naming the other patient. Drinking Game Participation Among High School and Incoming College Students: A Narrative Review. Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative properties results in debilitating musculoskeletal disorders. Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. The tip experiences attractive and repulsive forces that depend on the chemical and mechanical properties of the sample, yet conventional AFM tips are limited in their ability to resolve these time-varying forces. Body weight at hatching and viability of the chicks were not affected by the mycotoxin concentrations in the diets. Recently, an A(2B) adenosine receptor (A(2B)AR) knockout mouse illustrated that this receptor is a tissue protector, in that it inhibits VSMC proliferation and attenuates the inflammatory response following injury, including the release of TNF-alpha. Some patients also have antibodies against histones and antiphospholipid. Our ability to understand language often relies on common-sense knowledge - background information the speaker can assume is known by the reader.

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A randomized, controlled study of computer-based intervention in middle school struggling readers. Using a modified crossover design study, the author prospectively assessed fusional amplitudes in fifty participants with normal eye exams who met inclusion criteria. Accurate OCT-angiography Interpretation - Detection and Exclusion of Artifacts. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Our purpose was to review and assess definitions of treatment response and non-response used in patients with OAB. Consumers in the highest category of olestra consumption had statistically significantly reduced total serum cholesterol levels of -0.54 mmol/L (-21 mg/dL)compared with -0.14 mmol/L (-5 mg/dL) among olestra nonconsumers (P for trend,.03). Nentskii in the field of investigation of structure and significance of proteins.

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Four new carbazole alkaloids from Murraya koenigii that display anti-inflammatory and anti-microbial activities. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. This change induces corrections upon the nanosystem Hartree-Fock self-energies which enhance the fringes spaced by half the Fermi wavelength in the images giving the quantum conductance as a function of the tip position. In the intervening years, a great deal has been learned about the structures and mechanisms of viral membrane fusion proteins as well as about the endosomes in which different enveloped viruses fuse and the endosomal cues that trigger fusion. Effect of ectoparasite removal procedures on recapture of Microtus californicus. Mutants that cannot interact with potassium are only capable of catalyzing electroneutral exchange. These quantitative structure--activity relationships are discussed briefly in the light of general anesthesia theories. We will then outline potential new roles of BER in gene expression and RNA metabolism. Release and disposition of 3H-noradrenaline in the saphenous vein of neonate and adult dogs. Prognostic/predictive value of 207 serum factors in colorectal cancer treated with cediranib and/or chemotherapy.

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